4′-Chloroacetophenone 99%min CAS 99-91-2

Basic Info

Model No.: X-CAS 99-91-2

Type: Pharmaceutical Intermediates

Appearance: Liquid, Light Yellow Liquid

Colour: Yellow

EINECS No.:: 202-800-7

MF:: C8H7ClO

Melting Point: 154.59

Certificate::: GMP,Kosher,ISO9001,Non-GMO

Density: 1.192 G/mL At 25 °C(lit.)

Purity:: 99%Min

FP: 194 °F

Additional Info

Packaging:  in 25kg drum

Productivity: 10000kg per month

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

HS Code: 29147090


Product Description

p-Chloroacetophenone is a chemical reagent used in the synthesis of various pharmaceutically and biologically active compounds such as COX-2 inhibitors. Stable at room temperature in closed containers under normal storage and handling conditions.

Production methods: The reaction of chlorobenzene and acetic anhydride: to heat and stir the anhydrous aluminum chloride, the unhydrated disulphide and the dry chlorobenzene, and gradually drop into the anhydride in the boiling. After adding, stir back to 1h and recycle disulfide. When the reactants are cooled to room temperature, slowly pour into the crushed ice containing hydrochloric acid. The layer should be clear, if not clear, the hydrochloric acid should be added a little. Pour a small amount of benzene in the solution after extracting, collect oil layer, water layer with benzene extraction time, extract and reservoir merged, with about 15% of the caustic wash to acid, and then washed with water to neutral, drying, vacuum distillation, collect the coarse fraction, the frozen after 48 h, the separation of mother liquor, will melt crystallization is the finished product. Yield of 83.1%.


Used as a fluorescent whitening agent, pharmaceutical and intermediate materials

About product:


Product name








Molecular formula


Molecular weight




Colorless to light yellow liquid

Melting point

18 ºC

Boiling point

232 ºC



Refractive index




1Kg/bottle;25Kg/drum or as demand


Pharmaceutical Intermediates

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.

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