4-Butylresorcinol CAS 18979-61-8

Factory Supply 4-Butylresorcinol CAS 18979-61-8 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 4-Butylresorcinol Supplier & Manufacturer

Basic Info of 4-Butylresorcinol

What is 4-Butylresorcinol?

4-Butylresorcinol, sometimes called 4-n-Butylresorcinol, is a chemical used to treat hyperpigmentation of epidermis. Hyperpigmentation is thought to be related to tyrosinase, which produces melanin. Among the known chemical substances that inhibit the production of tyrosinase, such as hydroquinone, arbutin and kojic acid, 4-butyl resorcinol has been widely considered as the most powerful inhibitor.

4-Butylresorcinol is a resorcinol derivative, which can inhibit tyrosinase and tyrosinase related protein 1 (TRP-1). It can be used to reduce skin irritation and inhibit the production of melanin. Its hypopigmentation effect was first reported in 1995, and many subsequent studies have proved its effectiveness and safety in the treatment of chloasma with 0.1% cream, but few clinical studies have used 0.3% cream. Biochemical analysis of the inhibition of human tyrosinase activity showed that 4-n-butyl resorcinol was superior to other pigment reducers. Many studies have shown that it has good efficacy and safety in the treatment of chloasma.

4-Butylresorcinol can be used to produce safe cosmetic agents, with the clinical efficacy required by pharmacological agents. In addition, 4-n-butyl resorcinol plays a role mainly by inhibiting tyrosinase activity, and has no effect on MITF. The combination of 4-n-butyl resorcinol and hinokitiol showed a cumulative effect, which could reduce the expression of MITF.

4-Butylresorcinol Uses

  • 4-Butylresorcinol, likewise called Rucinol, is an efficient part of several cosmetics, which can hinder the development of melanin. Particularly, it can prevent the development of melanin by two enzymes, namely tyrosinase and also 5,6-dihydroxyindole-2-carboxylic acid oxidase.
  • 4-n-Butylresorcinol (Rucinol ®) (acquired by POLA in 1998) was selected by testing and manufacturing resorcinol by-products, which can create a solid affordable inhibition of tyrosinase activity. Melanin synthesis is catalyzed by tyrosinase and also tyrosinase associated proteins (TRP) – 1 and also – 2, while Rucinol ® It has actually been confirmed that it can prevent melanin synthesis in cultured computer mouse melanocytes by directly preventing tyrosinase activity as well as TRP. 1 task. 0.3% Rucinol ® It has been shown that the cream of the cream can properly treat hyperpigmentation illness, such as chloasma.
  • 4-Butylresorcinol is thought about as a prospective cytochrome P450 prevention. Since it straight inhibits tyrosinase, it can trigger hypopigmentation.
  • Glycerin is used for example prep work and also gel formation of polyacrylamide gel electrophoresis. Glycerin (5-10%) enhances the density of the sample, making the sample delaminate at the end of the gel example hole. Glycerin is additionally used to help cast slope gels and also as a protein stabilizer as well as storage buffer part.

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Application of 4-Butylresorcinol

4-n-Butylresorcinol inhibits pigment formation in the following way: 4-n-butylresorcinol inhibits the enzyme tyrosinase required for pigment synthesis (pigment production). 4-n-Butylresorcinol first inhibits pigmentation and then prevents the formation of melanin, which causes the intense pigmentation of moles. A disadvantage of 4-n-butylresorcinol in formulation is that it tends to discolour itself and the cosmetic or dermatological preparations containing it. Examples of its application are as follows:

Preparation of 4-Butylresorcinol

At present, there are 2 main methods to manufacture 4-n-butyl resorcinol:

Method 1: catalytic hydrogenation of 4-butyrylresorcinol in methanol with palladium carbon. Catalytic hydrogenation is a common gas liquid strong three-phase heterogeneous response. In order to make sure complete call in between the three stages, heat and also high pressure (15atm) problems are needed. Not just is the energy consumption high, but also the H2 in the system is flammable as well as explosive. In case of leakage, there is a substantial prospective security threat. In addition, palladium carbon is used, and also the cost is high.

Method 2: 4-butyrylresorcinol was lowered by zinc amalgam under hydrochloric acid at 120 ℃. Because the response occurs on the turned on zinc surface, a new zinc amalgam is needed for each and every step of the reaction; The higher the response temperature level, the greater the loss of hydrochloric acid focus will certainly be created, as well as it is necessary to include focused hydrochloric acid to preserve the level of acidity; A large amount of zinc amalgam is generated.

Both methods pointed out above are conventional methods reported today, and there are apparent issues in process boosting. On top of that, in the conventional reactor reaction, the response is exothermic and produces a huge amount of gas throughout feeding, which has a terrific possible safety threat as well as raises the difficulty of process amplification.


4-Butylresorcinol Supplier and Manufacturer

As a 4-butylresorcinol supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 4-butylresorcinol raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for 4-butylresorcinol and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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