
4-Acetylbiphenyl CAS 92-91-1



Factory Supply 4-Acetylbiphenyl CAS 92-91-1 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: 4-Acetylbiphenyl Supplier & Manufacturer
4-Acetylbiphenyl: The Complete Guide
- Item 1: Basic Info
- Item 2: What is 4-Acetylbiphenyl?
- Item 3: 4-Acetylbiphenyl Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of 4-Acetylbiphenyl
- Item 6: Preparation of 4-Acetylbiphenyl
- Item 7: Quality Control of 4-Acetylbiphenyl
- Item 8: Hot Sale Products
- Item 9: Get 4-Acetylbiphenyl Quotation
4-Acetylbiphenyl for Sale
Basic Info
Chemical Name: | 4-Acetylbiphenyl |
Other Name: | 4′-Phenyl Acetophenone; 4 Acetyl Biphenyl; 2-Mesitylenecarboxylic acid; 4′-Phenylacetophenone |
CAS: | 92-91-1 |
EINECS: | 202-202-6 |
Type: | Dye intermediate; Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C14H12O |
Molecular Weight: | 196.24 |
Melting point | 152-155 °C(lit.) |
Boiling point | 325-327 °C |
density | 1.2510 |
refractive index | 1.5920 (estimate) |
Fp | 168°C/8mm |
storage temp. | 2-8°C |
solubility | chloroform: soluble10mg/200microlitres, clear, colorless to faintly yellow |
form | neat |
color | White to Green to Brown |
Water Solubility | insoluble |
Brand Name: | Zhishang Chemical |
Provide: | 4-Acetylbiphenyl MSDS; 4-Acetylbiphenyl COA |
What is 4-Acetylbiphenyl?
4-Acetylbiphenyl is an intermediate in the synthesis of felbinac. Felbinac is a good non-steroidal anti-inflammatory medicine as well as an effective metabolite of advil. It was first detailed in Japan in 1986 for professional treatment Basic symptomatic medications for rheumatic diseases. Presently, the basic artificial approach of biphenylphenone has the negative aspects of not available resources, high toxicity, complex operation and also low yield.
Biphenylethanone (I) is one of the vital intermediates for the synthesis of felbinac, its pureness straight influences the pureness of felbinac, and also its contaminations will become brought into the product and also it is challenging to eliminate, and also it is likewise challenging to accomplish Expected impact, consequently, the preparation of high-purity biphenyl ethyl ketone plays an exceptionally important function in the preparation of felbinac.
4-Acetylbiphenyl is a biphenyl compound that can be prepared by suzuki-miyura and also Buchwald-Hartwig responses of aryl halides or trifluoroborates with arylboronic acids and also palladium stimulants.
4-Acetylbiphenyl Uses
As an important fine chemical intermediate, acetophenone is widely used in the chemical synthesis of pesticides and pharmaceuticals. Acetophenone (I) is one of the important intermediates in the synthesis of biphenyl acetic acid. Its purity directly affects the purity of biphenyl acetic acid.
4-Acetylbiphenyl was made use of to examine the inactivation of 7-ethoxy-4-trifluoromethylcoumarin O-deethylase activity by various aryl alkynes.
4-Acetylbiphenyl participated in the inactivation of 7-ethoxy-4-trifluoromethylcoumarin ortho-dethylase activity by various arylene. In addition, it is also used to prepare Schiff base.
The Manager has Something to Say

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Application of 4-Acetylbiphenyl
Biphenylphenone is an important fine chemical intermediate, which is widely used in the chemical synthesis of pesticides and pharmaceuticals. There are many synthetic methods reported in the literature, such as haloacetophenone coupling method, oxidation method, a-halogenated ketone dehalogenation method, biphenyl acetylation method, etc., but whether the raw materials are easy to obtain and whether the process is simple and convenient In terms of whether it is easy to realize industrial production, the biphenyl acetylation method is generally used.
- Preparation of felbinac
Add 100g of biphenylphenone, 176g of Na2S2O4, 500mL of morpholine and 14.7g of NaS.9H2O into a 3L three-neck flask, control the temperature at 110±2°C, stir for 4 hours, then cool to room temperature, add 400mL of 5% NaOH aqueous solution and 1000mL of 70% ethanol solution, reacted for 3h, cooled to room temperature, filtered with suction, adjusted the pH of the filtrate to 2-2.5 with concentrated hydrochloric acid, filtered to obtain 100g of crude felbinac, recrystallized the crude product and aqueous ethanol at a ratio of 1:1, cooled Stand at 0°C for 9 hours, filter to obtain 81g of felbinac finished product, the yield is 74%, m.p: 158-160°C. - Reparation of p-morpholinethioacylmethylbiphenyl
Add 1650kg (8.4mol) of biphenylphenone, 438g (13.7mol) of sublimed sulfur and 26350ml (30.2mol) of morpholine into the reaction flask, heat to reflux under stirring, react for 7 hours, cool down to 80°C, and then add 10000ml of methanol, Continue stirring for 0.5 hour, filter, wash the filter bottle twice with 2000ml of methanol, and dry to obtain 2293g of off-white solid condensate with a yield of 95% and a melting point of 137-139°C.
Preparation of 4-Acetylbiphenyl
- Mix 1542g (10mol) of biphenyl, 1021g (10mol) of acetic anhydride, 4-dimethylaminopyridine (15.42g) and dichloromethane (20000ml) and set aside.
- Mix 2825g (21.2mol) of aluminum trichloride and 27000ml of dichloromethane, cool to -10°C ~ -20°C and stir evenly, keep stirring at -10°C ~ -20°C and add the above biphenyl and acetic anhydride dropwise , a mixed solution of 4-dimethylaminopyridine and dichloromethane, the dropwise addition time is 60-90 minutes, keep this temperature for 1-2 hours, slowly add hydrochloric acid solution dropwise at -10°C~-20°C, wash with water three times , dried over anhydrous magnesium sulfate, dichloromethane was distilled off under reduced pressure to obtain 1.831kg of off-white solid. The yield is 93.3%, and the melting point is 121-123°C.
Add 500mL of dichloromethane to a 1L three-necked flask, then add 100g of biphenyl and 112g of anhydrous AlCl3, then slowly add 50mL of acetyl chloride under the protection of nitrogen, and control the dropwise temperature at 0-5°C under cooling in a cold well After the dropwise addition, keep the reaction at 0-5°C for 3 hours, pour the reactant into 1500mL of ice-water mixture, separate the organic layer, extract the water layer twice with 500mL*2 of dichloromethane, combine the organic layers, and desiccant-free Dry with water Na2SO4, filter out the desiccant, and concentrate the filtrate to dryness under reduced pressure to obtain 132 g of biphenylphenone with a yield of 95.5%, m.p: 117-119°C.
Add 231g of biphenyl, 300g of aluminum chloride, and 1300ml of 4# solvent into a 2000ml reaction flask. 141g of acetyl chloride was added dropwise at 46°C, and the temperature was maintained for 3 hours after the drop was completed. Then the reaction solution was poured into 2700ml of water containing 16% flocculant, 5g of activated carbon was added, stirred for 15 minutes and then filtered. The filter cake was washed twice with 50ml@2 water, the washing liquid was combined with the original filtrate, and the water layer was separated by a separatory funnel, and the organic layer was washed twice with 500ml@2 water, and the conversion rate of biphenyl was analyzed by sampling to 100%, and then distilled Recover the 4# solvent, pour the residual material liquid into 1400ml methanol while it is hot, and cool and crystallize. After filtration, 278 g of biphenyl ethyl ketone was obtained, the mother liquor was distilled to recover methanol, the raffinate was cooled and crystallized and filtered, and the filter cake was washed with a small amount of methanol to obtain 11 g of biphenyl ethyl ketone. A total of 289g of biphenylphenone was obtained, and the total yield was 98.3%. Product melting point: 119) 120e (mp118-120e), the content of benzophenone measured by gas chromatography internal standard method is 99.8%.
Reference
- 4-Acetylbiphenyl – PubChem
- Gu Gaolong, Song Xiahui, Fang Weihong, & Wang Wenming. (2006). Study on Synthetic Process of 4-Biphenylethanone. Jiangxi Chemical Industry (3), 79-80.v
4-Acetylbiphenyl Supplier and Manufacturer
As a 4-acetylbiphenyl supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 4-acetylbiphenyl raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for 4-acetylbiphenyl and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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After-Sales Service
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Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of 4-Acetylbiphenyl

