
4-Acetoxyindole CAS 5585-96-6



Factory Supply 4-Acetoxyindole CAS 5585-96-6 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: 4-Acetoxyindole Supplier & Manufacturer
4-Acetoxyindole: The Complete Guide
- Item 1: Basic Info of 4-Acetoxyindole
- Item 2: What is 4-Acetoxyindole?
- Item 3: 4-Acetoxyindole Uses
- Item 4: The Manager has Something to Say
- Item 5: Preparation of 4-Acetoxyindole
- Item 6: References
- Item 7: Quality Control of 4-Acetoxyindole
- Item 8: Hot Sale Products
- Item 9: Get 4-Acetoxyindole Quotation
4-Acetoxyindole for Sale
Basic Info of 4-Acetoxyindole
Chemical Name: | 4-Acetoxyindole |
Other Name: | 4-INDOXYL ACETATE; 4-INDOLYL ACETATE |
CAS: | 5585-96-6 |
EINECS: | 1312995-182-4 |
Type: | Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C10H9NO2 |
Molecular Weight: | 175.18 |
Melting point | 100-102°C |
Boiling point | 339.1±15.0 °C(Predicted) |
density | 1?+-.0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 16.38±0.30(Predicted) |
form | Solid |
color | Off-White to Beige |
Brand Name: | Zhishang Chemical |
Provide: | 4-Acetoxyindole MSDS; 4-Acetoxyindole COA |
What is 4-Acetoxyindole?
4-Acetoxyindole is an indole with acetyl team. It is made use of as the starting reactant for preparing 4-oxoquinoline and also as an anti HIV representative. In chromatographic analysis, it is used to help maximize the peak capability for separating low molecular weight molecules throughout slope elution.
4-Acetoxyindole is also known as 4-indole acetate. It can be used as a standard for reverse phase high-performance liquid chromatography in the separation process of small molecules. It can also be used as a reactant for the preparation of HIV attachment inhibitors, prostaglandin EP3 antagonists, indole nitroalkanes, and naked mushroom elements.
4-Acetoxyindole Uses
4-Acetoxyindole is a useful intermediate for the organic synthesis of Psilocine and Psilocine analogues.
Reactants used to prepare the following substances: •; HIV-1 adhesion inhibitor 1 •; Prostaglandin EP3 receptor antagonist, as a novel antiplatelet agent 2 •; Indolyl nitroalkane 3 • synthesized through N-bromosuccinimide catalysis; Saloxetine as medication 4
Reactants used for preparation:
- HIV-1 adhesion inhibitor
- Prostaglandin EP3 receptor antagonist as a novel antiplatelet drug
- Catalytic Synthesis of Indolyl Nitroalkanes with N-Bromosuccinimide
- Naked mushroom extract as a medicament
The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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If you want to buy 4-acetoxyindole, pls contact us to get a free quote.
Preparation of 4-Acetoxyindole
4-hydroxyindole (1 equiv of restricting reagent) was loaded into the vessel under N2, complied with by DCM (dichloromethane; 4-hydroxyindole based loading, 6 quantities). The response was cooled down to 0-5 ° C, and also pyridine (1.2 equiv.) was added dropwise at 0-5 ° C. Acetic anhydride (1.1 equiv) was included dropwise at 0-5 ° C and also the response was warmed up to 20-25 ° C for 1-1.5 hrs as well as stirred at 20-25 ° C for an extra 3 hrs. The response was tested and analyzed for conclusion. The response was after that washed 3 times with 20% aqueous citric acid solution (4-hydroxyindole based loading, 3 x 3 vol) and when with saturated NaHCO3 (4-hydroxyindole based loading, 3 vol). The DCM option was dried over MgSO4 and filtered, as well as the DCM layer was focused to half volume by purification. Heptane (based on 4-hydroxyindole loading, 6 quantities) was included and also additional DCM was eliminated by distillation till total rainfall of stage 1 occurred. The response was cooled to 15 ° C-25 ° C, as well as the strong was accumulated by filtering, cleaned with heptane (4-hydroxyindole based loading, 1 vol), and dried out under vacuum cleaner at 60 ° C overnight to offer 4-acetoxyindole indoles.
To 15.25 g of 4-benzyloxyindole (223 g/mol, 68.39 mmol, 1 eq.) in 200 mL of acetone was included 20 mL of acetic anhydride (21.6 g, 102.09 g/mol, 211.6 mmol, 3.1 eq.) 5 grams). 0.5 g powdered LiCl (42.39 g/mol, 11.80 mmol, 0.17 equiv) and also 0.5 g driver (Pd/C, 10%, oxidized kind). The blend was shaken vigorously under H2 at space temperature level as well as conventional stress for 16 hours until gas uptake stopped. TLC evaluation of the response mixture suggested regarding 50-75% insufficient conversion. The catalyst was filtered off, and 1.0 g of fresh stimulant was added as catalyst in addition to 10 mL of acetic acid (60.05 g/mol, 9.53 g, 158.7 mmol, 2.3 eq.) as well as 10 mL of triethylamine (101.19 g/mol, 13.7 g, 135.7 mmol, 2.0 eq.), and also hydrogenation continued for an additional 20 hrs till gas uptake stopped. An extra 0.5 g of driver was included as well as the mixture was trembled for an extra hour. The stimulant was filtered off, the solvent was eliminated on a rotary evaporator, as well as the resulting dark oil was liquified in 150 mL of ether, cleaned with 2 x 200 mL of H2O, dried over Na2SO4, as well as filtered. Drinking with 1 g of silica gel followed by filtration did not get rid of the dark color. The solvent was eliminated on a rotating evaporator. The crude item was taken shape at room temperature level as well as more dried out under oil pump vacuum at 50 ° C for 9 hrs to yield 4-acetoxyindole (11.19 g, 175.19 g/mol, 63.87 mmol, 93%) as light eco-friendly crystalline globs. The product of this reaction was utilized in the next step without more purification.
References
- 4-Acetoxyindole – PubChem
- [Chinese invention] CN201880078639.8 Preparation and use of psilocybin, different polymorphic forms, intermediates and formulations
4-Acetoxyindole Supplier and Manufacturer
As a 4-acetoxyindole supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best 4-acetoxyindole raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have demand for 4-acetoxyindole and related products, please contact our service staff Zhishang Chemical – White directly, we will provide you with high-quality products at the best price.
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*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
After-Sales Service
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*Product has any problem can return.
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Is there a discount?
Different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.
Quality Control of 4-Acetoxyindole

