
3'-Chloropropiophenone CAS 34841-35-5


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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: 3′-Chloropropiophenone Supplier & Manufacturer
3'-Chloropropiophenone: The Complete Guide
- Item 1: Basic Info of 3'-Chloropropiophenone
- Item 2: What is 3'-Chloropropiophenone?
- Item 3: 3'-Chloropropiophenone Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of 3'-Chloropropiophenone
- Item 6: Preparation of 3'-Chloropropiophenone
- Item 7: Quality Control of 3'-Chloropropiophenone
- Item 8: Hot Sale Products
- Item 9: Get 3'-Chloropropiophenone Quotation
3'-Chloropropiophenone for Sale
Basic Info of 3'-Chloropropiophenone
Chemical Name: | 3′-Chloropropiophenone |
Other Name: | 3-CHLORO PROPIOPHENONE; 3-Chloropropiophenone |
CAS: | 34841-35-5 |
EINECS: | 252-242-3 |
Type: | Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C9H9ClO |
Molecular Weight: | 168.62 |
Melting point | 45-47 °C(lit.) |
Boiling point | 124 °C14 mm Hg(lit.) |
density | 1.1115 (rough estimate) |
refractive index | 1.5350 (estimate) |
Fp | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in methanol. |
form | Crystalline Solid |
color | White to light yellow |
Brand Name: | Zhishang Chemical |
Provide: | 3′-Chloropropiophenone MSDS; 3′-Chloropropiophenone COA |
What is 3'-Chloropropiophenone?
3-Chloropropiophenone is a key intermediate in the synthesis of bupropion hydrochloride, dapoxetine and maraviroc. Bupropion hydrochloride is an antidepressant, which is a blocker of weak neuronal absorption of serotonin and norepinephrine. Bupropion can also be used as an adjunctive treatment for smoking cessation, viral infections, or sexual dysfunction.
Bupropion is a new type of antidepressant, and it can also play a smoking cessation effect by blocking the uptake of dopamine, serotonin and norepinephrine by nerves. It is widely used in clinical practice. The key intermediate of ketone. At present, the traditional process of industrial production of m-chloropropiophenone at home and abroad is that 1,2-dichloroethane is used as a solvent, aluminum trichloride is used as a catalyst, and Propiophenone is reacted with chlorine to obtain m-chloropropiophenone, but 1,2-dichloroethyl Alkane is flammable, highly toxic, and highly carcinogenic; aluminum trichloride vapor is irritating to the respiratory tract and causes bronchitis, and has a strong irritating effect on the skin and mucous membranes, and a large amount of acidic wastewater is produced during production. Industrial production is very difficult. Therefore, to seek advanced technology and low production cost, it is imperative to develop the green production technology of m-chloropropiophenone.
Reported in the patent, in 1,2-dichloroethane as solvent, under the catalysis of anhydrous aluminum trichloride, Propiophenone and chlorine generate chlorination reaction to synthesize m-chloropropiophenone, and the yield is 89%. Because this method uses a large amount of 1,2-dichloroethane as the reaction solvent during the synthesis, long-term contact and use will cause great harm to the human body. The pharmaceutical factory has banned the use of m-chloropropiophenone containing dichloroethane residues. As a raw material for the production of antidepressant bupropion.
3'-Chloropropiophenone Uses
- 3′-Chloropropiophenone is a key intermediate in the synthesis of bupropion hydrochloride, dapoxetine and maraviroc. Mainly used in laboratory organic synthesis and chemical production process.
- 3′-Chloropropiophenone is a reagent used for vinyl, alkylation and dienylation of ketones. It is also used to prepare thiazine derivatives with antibacterial activity.
- 3′- Chlorophenyl acetone has been used to prepare 1- (3-chlorophenyl) – 1-phenyl-1-propanol.
- 3′- Chlorophenyl acetone can be used as reactant (s) – 3-chloro-1-phenylpropanol was synthesized by biocatalytic asymmetric reduction.
1- (3-chlorophenyl) – 1-phenyl-1-propanol is phenylated with diphenylzinc in the presence of dihydroxy bis (sulfonamide) ligand.
(S) – dapoxetine, a selective serotonin reuptake inhibitor.
The Manager has Something to Say

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If you want to buy 3'-chloropropiophenone, pls contact us to get a free quote.
Application of 3'-Chloropropiophenone
3′-Chlorophenylpropanol, as an important intermediate in the synthesis of dapoxetine, plays a key role in the cost and quality of the entire drug. About the synthesis report of R-3′-chlorophenylpropanol, mainly focus on taking 3′-chloropropiophenone as raw material, through reducing agent, synthesizes target product.
The target compound is synthesized by using tetrahydrofuran as a solvent and a spiro boron ester compound as a catalyst. The cost of this process solvent and catalyst is relatively high. With 95% ethanol as solvent and potassium borohydride as reducing agent, the cost is low. However, the synthesized product is a mixture, which needs to be split before the target product can be formed, and the final total yield is low, resulting in high cost. DMSO is used as solvent, and chiral catalysts are not common and have high cost. The post-processing is complicated and the energy consumption is large. Using ethylene glycol dimethyl ether as solvent and sodium borohydride as reducing agent. The cost of the solvent is high, and the product is a mixture that needs to be split.
To sum up, in the synthesis technique of R-3′-chlorophenylpropanol, there are ubiquitous shortcomings such as high solvent and reducing agent cost, difficult aftertreatment, difficult control of reaction process, low selectivity, low chiral purity, etc. To sum up, the research on the synthesis process of R-3′-chlorophenylpropanol, the development of a production process with lower cost, convenient handling and better product quality, is of great significance to the synthesis of the above-mentioned drugs and the treatment of related diseases. Has a broad market prospect.
Adopt the technique of 3-chloropropiophenone to synthesize 3′-chlorophenylpropanol, the concrete steps are as follows:
1) Add 3′-chloropropiophenone and L-prolinol successively to 95% ethanol and stir;
2) Cool down after the reaction solution is completely dissolved;
3) Add potassium borohydride to the reaction solution in batches, and keep the temperature after adding;
4) After the reaction solution is heated to reflux for reaction, the reaction solution is concentrated under reduced pressure;
5) Add n-hexane to the reaction solution, heat, and then add activated carbon to decolorize by heat preservation;
6) Filter the reaction solution, rinse the filter cake with 500-700ml of n-hexane, and collect the filtrate;
7) The filtrate is crystallized and filtered, and the filter cake is rinsed once with 300-500ml of n-hexane, and dried in vacuum to obtain 3′-chlorophenylpropanol.
The method includes the steps:
1) Make 3-chloropropiophenone and 3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane The alkane reaction obtains the compound whose structure is shown in formula 5;
2) reacting the compound with the structure shown in formula 5 with the chiral auxiliary (S)-tert-butyl sulfinamide to generate the compound shown in the structure shown in formula 4;
3) reducing the compound of formula 4 to obtain the compound of formula 3; and
4) (S)-3-((3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]octane-8-yl)-1-phenylpropylamine hydrochloride is treated with an alkaline solution to obtain the compound whose structure is shown in formula 2;
Preparation of 3'-Chloropropiophenone
Adopt m-aminopropiophenone and sodium nitrite to obtain after diazotization and chlorination, and the mol ratio between m-aminopropiophenone and sodium nitrite is 1: 1~1: 1.2.
The specific operation steps are:
Add m-aminobenzophenone and an appropriate amount of hydrochloric acid into the reaction kettle, stir and cool to 0 °C, drop an aqueous solution of sodium nitrite, control the temperature at 0 to 5 °C, and use starch potassium iodide test paper to detect the presence of excess nitrous acid. , the diazonium salt solution was added to the pre-prepared cuprous chloride solution that had been cooled to 0 °C to obtain the crude 3′-chloropropiophenone, which was washed twice with hydrochloric acid and water, and then washed with 5% sodium carbonate. The solution is washed, finally washed with water, dried and distilled under reduced pressure to obtain a product with a yield of about 60.5% and a content of 90% to 95%.
Adopt the chlorination of p-propiophenone to obtain 3′-chloropropiophenone, and the chemicals used in this method are: propiophenone, metal trichloride, solvent A, chlorine Cl Miscible metal trichloride salts.
The operation steps are as follows:
The first step, adding an appropriate amount of metal trichloride and solvent A in the reactor, adding Propiophenone solution dropwise under agitation, feeding chlorine gas Cl , and performing chromatography to track the reaction in the range of 15 to 70° C., Stop chlorination in about 6 to 10 hours;
The second step, low temperature hydrolysis;
The third step, washing and layering;
The 4th step, underpressure distillation obtains the target crude product;
The fifth step, rectifying the crude product at a temperature of about 170° C. obtains a fine product with a content of 99.7% to 99.9%; its yield is 88% to 90%;
Reference
- 3′-Chloropropiophenone – PubChem
- CN200410065482.5. A kind of method for preparing 3′-chloropropiophenone
3'-Chloropropiophenone Supplier and Manufacturer
As a 3′-chloropropiophenone supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 3′-chloropropiophenone raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for 3′-chloropropiophenone and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
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The different quantity has different discount.
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3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of 3'-Chloropropiophenone

