3-Chloroperoxybenzoic Acid CAS 937-14-4

CN201710478721.7 discloses a synthesis process of minoxidil. Minoxidil can directly act on the blood vessel wall, dilate small arteries, reduce peripheral resistance, lower blood pressure, and increase heart rate and cardiac output, but its The antihypertensive effect is more significant and lasting than that of hydralazine. The process is as follows: First, 2,4-diamino-6-chloropyrimidine is oxidized with m-chloroperoxybenzoic acid to obtain intermediate 2,6-diamino-4-chloropyrimidine-1-oxide, and then intermediate 2,6- Diamino-4-chloropyrimidine-1-oxide and piperidine are condensed into crude minoxidil under alkaline conditions, and finally the crude minoxidil is crystallized in isopropanol and purified to obtain refined minoxidil I finished. The process principle of the invention is simple, the operation is convenient, the product yield is high, and the purity is good.

Epoxy can be polymerized to form a cured product with excellent electrochemical, heat and humidity resistance. Among them, the polymer formed by polymerization of diepoxide as a key intermediate can be widely used in resists, coating agents, inks, adhesives, sealants, encapsulants, composite materials, optical materials, electronic materials, etc. multiple fields. CN201911328227.8 discloses a method for preparing diepoxides in one pot. The method comprises the following steps: S1. Epoxidation reaction: at low temperature, add diolefins into the reactor, slowly add m-chloroperoxybenzoic acid solution dropwise, and react to obtain the crude product solution of diepoxide; S2. Separation and purification: adding a reducing agent aqueous solution to the crude solution of the diepoxide, performing a reduction reaction, extracting and separating the organic phase, neutralizing the reaction, extracting and separating the organic phase, washing with water, removing water, filtering, and distilling the filtrate under reduced pressure to obtain the diepoxide. The present invention avoids the solvent distilled out by high vacuum in the traditional process, does not need to separate the solid raw material of m-chloroperoxybenzoic acid, and obtains diepoxide through one-pot reaction of diene and m-chloroperoxybenzoic acid solution, which reduces the process operation Difficulty increases safety, and the purity of the prepared diepoxide is over 91%, and the yield is over 95%, which is beneficial to large-scale industrial production.