2-Methylresorcinol CAS 608-25-3

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  • Appearance: Gray or light brown crystalline powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 2-Methylresorcinol Supplier & Manufacturer

Basic Info

What is 2-Methylresorcinol?

2,6-Dihydroxytoluene, also known as 2-methylresorcinol, is a white to off-white crystal chemical substance with a molecular formula of C7H8O2, a molecular weight of 124.1372, a boiling point of 264°C, and a density of 1.594 g/cm³. It is easy to dissolve In water, it has weak acidity and can undergo chemical reactions to produce ethers, esters, ketones and other substances.

The discovery of this compound was first isolated from ambergris by German chemist Paul Friedländer, and then American chemist W. H. Carothers used it as a raw material to prepare the first polyamide fiber – nylon 6,6. This discovery is useful for plastics and fibers Industry had a major impact. Later, with the development of science and technology, it has made good research progress in pesticide manufacturing and pharmaceutical industry.

2-Methylresorcinol Uses

2-Methyl Resorcinol is used as medicine, pesticide, dye intermediate, hair auxiliary, etc.

2-Methyl Resorcinol is used to prepare aromatic benzoporphyrins, tripyran analogs and C-5-bromo-2-hydroxyphenyl calix 2-methyl Resorcinol. In addition, it is also used in both oxidizing and non oxidizing hair dye formulations.

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Application of 2-Methylresorcinol

Because 2,6-dihydroxytoluene has many important physical and chemical properties, it has a very important application in the chemical industry, and is one of the very important chemical intermediates, and because it has good disinfection and sterilization functions, recently It has also been widely used in shampoos, skin care products and other products in recent years. The following is a detailed introduction to the application of this compound:

  1. Manufacturing of pigments and dyes: 2,6-dihydroxytoluene is an important raw material for many pigments and dyes, through 2,6-dihydroxytoluene, two new colored pigments with electron-donating groups with different functions can be synthesized. A colorant can be used on high energy polymers.
  2. Medicine: 1,3-dihydroxy-2-methylanthraquinone is obtained by cyclization with phthalic anhydride and 2,6-dihydroxytoluene, and then selectively acetylated in the presence of acetylboronic acid to obtain 1- Hydroxy-2-methyl-3-acetoxyanthraquinone was methylated under conditions of potassium carbonate and methyl iodide to obtain 1-methoxy-2-methyl-3-acetoxyanthraquinone, and then NBS Bromination gives 1-methoxyl-2-ethoxyl 3-acetylamino anthraquinone, the bromide is condensed with sodium ethoxide to synthesize 1-methoxyl-2ethoxyl-3-hydroxyl anthraquinone, the compound is Short echinacea, often used in medicine to treat nasopharyngeal carcinoma. In addition, it can also be used to treat skin diseases, respiratory infections, antibacterial and anti-inflammatory drugs, etc.
  3. Pesticide production: It can be used to produce pesticides such as insecticides, herbicides and fungicides. For example, as an intermediate of salicylic acid dipyrimidine herbicides (such as KIH-2023).
  4. Materials: A series of porphyrin porphine compounds were synthesized using this compound as a raw material. These compounds have a wide range of applications in polymer materials, molecular targeted drugs and chemical catalysis.
  5. Polymer production: used as a stabilizer for polymers to improve the durability and service life of polymers.
  6. Quality control: One of the indicators commonly used in water quality testing, it can detect the content of chlorine in water.

The Synthetic Method of 2-Methylresorcinol

There are many synthesis methods of 2,6-dihydroxytoluene, which are mainly divided into: 2,6-diaminotoluene method, p-toluene method, glutaric acid method, 1,3-cyclohexanedi The ketone method, resorcinol method and other methods have been streamlining and improving the relevant experimental steps. The following are the detailed introductions of several common synthetic methods:

Using glutaric acid as the initial raw material, under the catalysis of nitrobenzene and aluminum chloride, it reacts with acetyl chloride to generate 2-methyl-1,3-cyclohexanedione, 2-methyl-1,3-cyclohexane The target product 2,6-dihydroxytoluene can be obtained by reacting hexanedione with acetic anhydride and then hydrolyzing it.

CAUTION: The acetic anhydride vapor used in this route is toxic, so great care needs to be taken when experimenting. Moreover, this synthetic route is relatively complicated and requires three-step reactions to complete, which will produce more by-products, which is inconvenient for the separation and purification of products, making the post-treatment relatively complicated, and the pollution to the environment is also serious, and the reaction conditions are difficult. Control, the total recovery is about 50%.

Using p-toluic acid as raw material, after sulfonation reaction, hydrolysis under the condition of strong alkali NaOH and KOH, the generated salt is acidified with hydrochloric acid, and finally decarboxylated under the condition of nitrobenzene to obtain the target product.

The synthesis route undergoes three-step reactions. The first two steps require the use of a large amount of strong acids and bases such as sulfuric acid, hydrochloric acid, sodium hydroxide, and potassium hydroxide. It will become serious, which is not in line with the principles of green chemistry. This reaction causes the total yield of target product to be relatively low owing to many steps are complicated in operation in addition, can only reach about 50%.

1,3-Cyclohexanedione reacts with the aqueous solution of dimethylamine and the formaldehyde solution in the methanol medium, then transfers to the autoclave to carry out the hydrogenation reaction under the catalysis of palladium carbon to generate the intermediate 2-methyl-1, 3-cyclohexanedione and then 2-methyl-1,3-cyclohexanedione are dehydrogenated in mesitylene under reflux to obtain the product 2,6-dihydroxytoluene.

This method is divided into two steps. First, 2,6-dinitrotoluene is used for hydrogenation reaction under high temperature and high pressure conditions, and then under acetic acid system, palladium carbon is used as a catalyst, and 2,6-dinitrotoluene is hydrolyzed under high temperature and high pressure conditions to obtain 2,6- Dihydroxytoluene.


  • 2-Methylresorcinol – PubChem
  • Feng, Yu; et al Journal of the American Chemical Society (2016), 138(22), 7130-7142.
  • Wang Chunpeng, Zhao Linwu, Liu Yi, et al. Preparation and Properties of Resorcinol-Phenol-Formaldehyde Resin[J]. Forest Products Chemistry and Industry, 1999(4):23-28.

2-Methylresorcinol Supplier and Manufacturer

As a 2-methylresorcino supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 2-methylresorcino raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for 2-methylresorcino and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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