2-Bromochlorobenzene CAS 694-80-4

Ortho-bromochlorobenzene is 2-bromochlorobenzene. It likewise has two isomers, particularly m-bromochlorobenzene and also p-bromochlorobenzene, with a relative molecular mass of 191.46. All 3 compounds are hazardous and also stronger than the corresponding dichloride. a lot more. It responds with steel Mg in ether to produce p-chlorophenyl magnesium bromide. Take o-chloroaniline as basic material, blend it with concentrated hydrobromic acid, as well as minimize the temperature to 0 ° C. Under mixing, quickly add sodium nitrite aqueous remedy to nitrogenize o-chloroaniline to produce diazonium salt, which should be controlled throughout the reaction. The temperature does not surpass 10 ℃. Then take on the Sandmeyer response, include driver cuprous bromide as well as hydrobromic acid in the reaction system, decay the diazonium salt, the decomposition reaction is accomplished at the steaming temperature, after the reaction is completed, stand, take out the reduced natural layer, wash with water, Dry to eliminate water, fix under minimized pressure to obtain o-bromochlorobenzene.

Chlorobenzene dichloroethane is used for the treatment of adrenal cortical carcinoma and its metastatic carcinoma, and also for adrenal hyperplasia or tumor-induced hypercortisolism. In order to avoid insufficiency of adrenal cortex during treatment, glucocorticoids can be supplemented appropriately. Ortho-chlorobromobenzene is used as chlorobenzene dichloroethane pharmaceutical intermediate, and its synthesis method is good and bad for improving pharmaceutical synthesis product quality, and reducing by-product content has important economic significance.