2-Aminooxazole CAS 4570-45-0
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What is 2-Aminooxazole?
2-Aminooxazole (2ao), an N-heterocyclic molecule, has been proposed as an intermediate for prebiotic synthesis. It has been proved that it can be synthesized from small molecules existing in interstellar space, such as cyanamide and ethanolaldehyde.
It is estimated that 2-aminooxazole can survive ultraviolet radiation and cosmic rays in the thick cloud ice mantle after cloud collapse. On the contrary, it will be very unstable on the surface of cold solar system objects such as Kuiper Belt objects, but the molecule can still survive in dust particles or cometary bodies.
The use of 2-aminooxazole scaffolds as a new privileged structure in pharmaceutical chemistry has been studied. Since 2-aminothiazole scaffolds are widely used in many bioactive molecules, there are few studies on 2-aminooxazole scaffolds and isosteric 2-aminothiazole, whether in the early drug discovery stage or in the market. We first established a synthetic scheme for the preparation of N, 4-disubstituted 2-aminooxazole, and then evaluated the biological and pharmacokinetic characteristics of a small group of 2-aminooxazole and corresponding 2-aminothiazole.
- 2-Aminooxazole – PubChem
- 2-aminooxazole in astrophysical environments: IR spectra and destruction cross sections for energetic processing Belén Maté, Ricardo Carrasco-Herrera, Vicente Timón, Isabel Tanarro, Victor J. Herrero, Héctor Carrascosa, Guillermo M. Muñoz Caro, Cristóbal González-Díaz, Izaskun Jiménez-Serra [Submitted on 15 Jan 2021, Cornell University]
- 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry
Elisa Azzali, Miriam Girardini, Giannamaria Annunziato, Marialaura Pavone, Federica Vacondio, Giorgia Mori, Maria Rosalia Pasca, Gabriele Costantino, and Marco Pieroni* [Publication Date:June 8, 2020, ACS Publications]
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