
2-Acetylbutyrolactone CAS 517-23-7
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- Appearance: Colorless liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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2-Acetylbutyrolactone: The Complete Guide
- Item 1: Basic Info of 2-Acetylbutyrolactone
- Item 2: What is 2-Acetylbutyrolactone?
- Item 3: 2-Acetylbutyrolactone Uses
- Item 4: Preparation of 2-Acetylbutyrolactone
- Item 5: Reference
- Item 6: The Manager has Something to Say
- Item 7: Quality Control of 2-Acetylbutyrolactone
- Item 8: Hot Sale Products
- Item 9: Get 2-Acetylbutyrolactone Quotation
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Basic Info of 2-Acetylbutyrolactone
Chemical Name: | 2-Acetylbutyrolactone |
Other Name: | Alpa-acetyl-gama-butyl ester; 2-Acetyl-γ-butyrolactone |
CAS: | 517-23-7 |
EINECS: | 208-235-2 |
Type: | Pesticide; Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C6H8O3 |
Molecular Weight: | 128.13 |
Melting point | <25 °C |
Boiling point | 107-108 °C5 mm Hg(lit.) |
density | 1.19 g/mL at 25 °C(lit.) |
refractive index | n20/D 1.459(lit.) |
Fp | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 200g/l |
form | Liquid |
pka | 12.00±0.20(Predicted) |
color | Clear |
Water Solubility | 310 g/L (20 ºC) |
Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
Brand Name: | Zhishang Chemical |
Provide: | 2-Acetylbutyrolactone MSDS; 2-Acetylbutyrolactone COA |
What is 2-Acetylbutyrolactone?
Alpa-acetyl-gama-butyl ester, likewise called 2-acetyl-γ-butyrolactone, is a crucial natural chemical raw material, an intermediate for the preparation of chlorophyll, as well as can likewise be utilized in the pharmaceutical market to make anti-angina pectoris medications. The raw materials for the preparation of vitamin B1 can additionally be used to synthesize 3,4-disubstituted pyridine as well as 5-(β-hydroxyethyl)-4-methylthiazole, which are widely utilized.
2-Acetylbutyrolactone is an important intermediate in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5- (2-hydroxyethyl) – 4-methylthiazole. In the presence of 2-Acetylbutyrolactone, tert butyl isocyanate reacts with dialkyl acetylene dicarboxylate to form dialkyl (E) -2-{(tert butyl amino) [2-oxo-4,5-dihydro-3 (2H) – furanyl] methyl}-2-maleate. In addition, 2-Acetylbutyrolactone reacted with thiosemicarbazone and 3- (2-bromo-acetyl) – chrome-2-one in absolute ethanol to produce 3-{2-[5-hydroxyl-4- (2-hydroxy-ethyl) – 3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chrome-2-one in good yield. In addition, 2-Acetylbutyrolactone can also be used as the raw material for the synthesis of pilocarpine, which is the main drug for the treatment of narrow-angle and wide-angle glaucoma. In addition, the chemical can also be used as a fluorescent reagent for the quantitative spectrofluorimetric determination of primary amines, which has been proved to be as accurate and accurate as the official or other reported methods.
2-Acetylbutyrolactone Uses
- 2-Acetylbutyrolactone is an intermediate for the synthesis of 2,4-disubstituted pyridine. A fluorescent reagent for spectrofluorimetric determination of primary amine.
- 2-Acetylbutyrolactone was used to synthesize 3,4-disubstituted pyridine; 5- (b-hydroxyethyl) – 4-methylthiazole.
- 2-Acetylbutyrolactone is an important intermediate in the synthesis of vitamin B. It is also an intermediate for the synthesis of 3,4-disubstituted pyridine and 5-(β-hydroxyethyl)-4-methylthiazole.
- Fluorescence spectrometry
2-Acetylbutyrolactone itself has only slight fluorescence, but its derivatives show high UV fluorescence. Carbonyl group can easily react with amine to form Schiff base. It is for this reason that 2-Acetylbutyrolactone is often used to confirm the production of amines in organic synthesis. 2-Acetylbutyrolactone can also form fluorescent molecules with aromatic amines through the Japp Klingemann reaction. - Drug precursor
2-Acetylbutyrolactone is used as a precursor of many drugs, including santalene and α- Methylene- γ- Butyrolactone.
Preparation of 2-Acetylbutyrolactone
2-Acetylbutyrolactone can be prepared by the condensation reaction of acetate (such as ethyl acetate) and butyrolactone in alkaline solution.
2-Acetylbutyrolactone can also be prepared by reacting ethylene oxide with ethyl acetoacetate under alkaline conditions.
Reference
- 2-Acetylbutyrolactone – WikiPedia
- 2-Acetylbutyrolactone – PubChem
The Manager has Something to Say

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