1-Methylimidazole CAS 616-47-7

N-methylimidazole is an important raw material for synthesizing pharmaceutical intermediates, used for the preparation of losartan, nitazofenone, 1-methylimidazole-5-formyl chloride hydrochloride and naphthimidazole hydrochloride, etc.; in the field of pesticides , is widely used in the synthesis of fungicides and plant growth promoters, for example: N-methylimidazole is used as a cationic parent to undergo quaternization reaction to synthesize ionic liquids of imidazoles; in addition, N-methylimidazole is also used in epoxy resins and other resin curing agents, adhesives, etc.; N-methylimidazole also has a great application in the field of casting and glass fiber reinforced plastics.

Gadobutrol is a gadolinium-containing contrast agent used in nuclear spin tomography and has been used in Approved in the indication “Contrast Magnification in Magnetic Resonance Tomography of the Cranial and Spine”. By using weak bases such as lithium hydroxide or N-methylimidazole, this method has the advantage of high throughput without the need for isolation and intermediate purification of intermediates. In the process, lithium salts can advantageously be recovered and then fed back into the production cycle again.

Compared to prior art methods, waste generation is more advantageous because all steps are carried out in one “pot”, thereby eliminating mother liquor work-up, cleaning of filter units, etc. By accurately determining the ligand content prior to gadolinium complexation, gadolinium in wastewater can be successfully avoided because the amount of gadolinium can be adjusted in such a way that all metals are complexed by butanol ligands. The method can be managed with agitators and filter devices. Intermediate clean-up is performed with water only, no drying is required, and subsequent preparations can be carried out directly. This ensures optimal equipment usage and allows semi-continuous operation.

In addition, it can also be used to prepare ionic liquid corrosion inhibitors for oilfield water. Using N-methylimidazole as the starting material, the imidazole-type ionic liquid synthesized by a two-step method is used as the main agent for sustained release, and several other compounds are added as auxiliary retarders. Synthetic oilfield water injection compound corrosion inhibitor with release agent. This method can be carried out in sequence as follows:

(1) At a certain temperature, the N-methylimidazole and bromo-n-butane or benzyl chloride are mixed and reacted under stirring, and after the reaction for several hours, the unreacted substances are washed and removed to obtain the halide of N-methylimidazole.

(2) Mixing the product obtained in step (1) with the selected compound, adding a solvent, stirring and reacting at a certain temperature for a period of time, the reaction solution is extracted, washed, and treated by removing the solvent to obtain each target product.

(3) Compounding the product obtained in step (2) with urotropine, OP-10, potassium iodide and thiourea in a certain proportion to obtain a corrosion inhibitor with extremely high corrosion inhibition efficiency. The raw materials required by the invention are simple and easy to obtain, the operation process is simple and safe, the reaction time is short, the cost is low, the yield is high, the corrosion inhibition performance is strong, and the invention is suitable for industrial scale production and has strong practicability.