γ aminobutyric acid CAS NO 56-12-2

γ aminobutyric acid CAS NO 56-12-2

An important inhibitory neurotransmitter. The foods contain γ-aminobutyric acid (GABA) at an amount that shows immediate effect of suppressing autonomic nerve activity related to blood pressure increase. Reacts with isothiocyanates to produce thioureas which have antifungal activity.

Production methods

1. There are synthetic methods and fermentation methods.

1. The synthesis method is made by the open loop of pyrrolidone. Lime digestion with distilled water into the lime milk, pumped in hydrolysis reaction kettle, adding pyrrolidone, up to 125-125 ℃, reaction pressure keep in 0.29 MPa, thermal reaction above 10-14 h. Reaction after cooling to 30 ℃ discharging filtering, washing with distilled water. Filtrate and ammonium bicarbonate, until no calcium ion detection, plus 30 min at 80 ℃ heat preservation decolorizing activated carbon, 60 ℃ filtration, washed with distilled water, wash a merger with the filtrate, at 60 ℃ decompression enrichment to precipitate crystallization, adding ethanol, cooling, filtering, drying, and finished product yield was above 85%.

2. The fermentation method USES e. coli as a strain. The fermentation medium is bran hydrolysate, corn syrup, peptone, magnesium sulfate and sodium chloride. With soybean oil as defoaming agent, the dosage was about 0.1%, and the fermentation unit was about 100 enzyme unit /ml fermentation liquid. In the distillation process, the use of e. coli decarboxylase, gamma – L – glutamic acid can be converted to ammonia butyric acid in aqueous solution can disintegrate into cationic characteristics, using strongly acidic styrene type cation exchange resin to ion exchange, ammonia elution, extraction, purification, then through resin concentration, crystallization, drying for a quick finished products.

use

Can reduce blood ammonia, promote brain metabolism.

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.