α-Naphthoflavone CAS 604-59-1
Factory Supply α-Naphthoflavone CAS 604-59-1 with Best Price
- Appearance: Yellow powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: α-Naphthoflavone Supplier & Manufacturer
α-Naphthoflavone: The Complete Guide
α-Naphthoflavone for Sale
|Other Name:||2-Phenyl-4H-benzo[h]chromen-4-one; alpha-Naphthoflavone|
What is α-Naphthoflavone?
α- Naphthalene flavone, additionally referred to as 7,8-benzoflavone and 2-phenyl-benzo (h) chrome-4-one, is an artificial flavone derivative, which is an efficient and affordable aromatase prevention with IC50 and Ki worths of 0.5 as well as 0.2 specifically μ M 。
α- Naphthoquinone is a reliable prevention of aromatase, which transforms testosterone right into estrogen. α – Naphthoflavone has been shown to cause irregular testicular development in young chickens.
α- Naphthylflavone is used as an indicator of oxidation and reduction.
α- Naphthylflavone is a kind of flavonoids that can act on μ- Opioid receptors to treat pain. It is also used as a non steroidal aromatase inhibitor for the treatment of breast cancer.
The extended flavonoids are produced by the formal fusion of benzene ring and the h side of flavonoids. A synthetic compound that is an inhibitor of aromatase (EC 22.214.171.124).
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Application of α-Naphthoflavone
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription variable that can advertise the expression of stage I and also phase II allogenic chemical metabolic enzyme genes, including cytochrome P450 (CYP) subtypes CYP1A1 and also CYP1A2. α- Naphthalene flavone is a sort of flavone, which can regulate the metabolism of xenobiotics at numerous points. It annoys AhR and also obstructs the expression of phase I as well as stage II genes at nanomolar focus, although it can obstruct the expression of stage I as well as stage II genes at higher focus (10 μ M) Next fired up AhR. α- Naphthoflavone prevents CYP19 (aromatase), CYP1A1, CYP1A2 as well as CYP1B1 (IC50 is 500, 60, 6 and also 5 nM specifically), while it triggers CYP3A4 (Kd=7.4 μ M ） 。 In the existence of artificial estrogen α- Naphthene flavonoids might cause cancer causing impacts.
- alpha-Naphthoflavone – WikiPedia
- Kellis JT Jr; Vickery LE (1984). “Inhibition of human estrogen synthetase (aromatase) by flavones”. Science.
α-Naphthoflavone Supplier and Manufacturer
As a α-naphthoflavone supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best α-naphthoflavone raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for α-naphthoflavone and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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