Vitamin B12 Cobalamin CAS 68-19-9
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- Appearance: Red powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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Vitamin B12 Cobalamin: The Complete Guide
Vitamin B12 Cobalamin for Sale
Basic Info of Vitamin B12 Cobalamin
Vitamin B12 Cobalamin
Vitamin B12; Cobalamin; Cyanocobalamin b12; Vitamin b12 cyanocobalamin
Food additives; Pharmaceutical raw materials; Organic raw materials; Plant extracts; Flavors and fragrances; Daily chemicals; Pharmaceuticals, pesticides, dye intermediates
What is Vitamin B12 Cobalamin?
Cyanocobalamin (cbl), also known as vitamin B12, is a class of water-soluble compounds containing cobalt. Different forms of cobalt have been discovered since the 1960s. The first one was cyanocobalamin, followed by methylcobalt. Amine, Hydroxocobalamin and Adenosylcobalamin, among which Hydroxocobalamin belongs to the natural form of Cyanocobalamin and exists in food, and the other three forms need to be industrially synthesized. As an important cofactor in the body, cyanocobalamin plays a key role in the methionine (methionine) cycle of homocysteine metabolism and the isomerization of methylmalonic acid-succinic acid. Oxidative stress, intracellular signal transduction, apoptosis and other processes.
Cyanocobalamin in nature is synthesized by microbes. Higher animals and plants can not manufacture cyanocobalamin by themselves. Consequently, the human body needs to ingest it via animal food, including milk, eggs, fish and meat. The American Institute of Medicine suggests that the intake of cyanocobalamin is 2.4 μg/ d, as well as the Chinese Nutrition Association advises 1.0-3.2 μg/ d.
Generally, vitamin B12 can promote the growth as well as maturation of red cell, maintain the body’s hematopoietic feature in a regular state, protect against pernicious anemia, maintain the wellness of the nerve system, and also promote protein synthesis. Jaclyn London, MS, RD, CDN, Supervisor of Nourishment at The Good Home cleaning Institute, claimed: “As you age, getting B12 daily is critical as a shortage can lead to cognitive decline and also impaired neurological feature. Vitamin B12 is necessary in the human body. In biochemical responses, it is associated with DNA synthesis, change of damaging substances, and so on, and also is closely related to the maturation of blood cells, preserving the wellness of blood vessels as well as nervous system. Lack of B12 might result in neurological signs and symptoms such as megaloblastic anemia, vascular sclerosis and depression.
Vitamin B12 Cobalamin Uses
Vitamin B12 plays a very crucial role in several functions of the body, consisting of: DNA synthesis, energy manufacturing, keeping the wellness of afferent neuron, red cell development, nervous system feature. B12 is found in lots of foods and is bound in the healthy protein particles of the food.
Some common indications of vitamin B12 shortage include: lowered cognitive function, such as troubles with memory or understanding, tiredness, sleepiness, bowel irregularity, vague feelings, clinical depression or irritation, frustration, problem maintaining equilibrium, sore tongue, mouth sores, really feel numb,
Visual modifications. Risk factors for vitamin B12 shortage are also related to insulin levels, so some medications for type 2 diabetes mellitus can raise the danger of vitamin B12 shortage. In addition, the complying with threat aspects can additionally enhance the chance of vitamin B12 shortage: alcoholic abuse, cigarette smoking, taking specific prescription medications, consisting of antacids and also some type 2 diabetes medicines, having an autoimmune condition such as diabetes or thyroid disease, pure vegan diet regimen, certain food poisonings such as Crohn’s disease, gastric bypass surgery or removal of part of the belly, aging, have stomach problems, this is because an irregular gastrointestinal tract may prevent vitamin B12 release or take in.
Vitamin B12 injections, which do not damage the intestinal tract, can likewise lower the danger of vitamin B12 deficiency and also relevant issues. Complications of extreme vitamin B12 shortage include: cardiovascular disease, neurocognitive problems, sychronisation troubles, outer neuropathy, vision loss, the inability to conceive, and also much more.
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Application of Vitamin B12 Cobalamin
Medical as well as medical care applications
It is generally utilized to deal with different VB12 deficiency, such as: megaloblastic anemia, anemia triggered by medication poisoning, aplastic anemia and leukopenia, and so on; made use of in combination with pantothenic acid, it can stop destructive anemia and help Absorption of Fe2+ and also secretion of stomach acid; likewise utilized to deal with joint inflammation, facial nerve palsy, trigeminal neuralgia, liver disease, herpes, bronchial asthma and also various other allergies, atopic dermatitis, hives, dermatitis and also bursitis; VB12 can also For the therapy of anxiety, irritation, sleeplessness, memory loss, and anxiety. New research study suggests that VB12 deficiency additionally adds to mental disorders such as clinical depression. VB12 is very risk-free as a healing representative or health care product, and also no poisoning phenomenon was found by intravenous or intramuscular injection of VB12 that was several thousand times greater than RDA.
- Application in feed
VB12 can promote the development as well as growth of fowl and also animals, especially young birds and also young animals, and also enhance the use rate of feed healthy protein, so it can be utilized as a feed additive. Dealing with fish eggs or fry with VB12 aqueous solution can enhance the tolerance of fish to poisonous substances in water such as benzene and also heavy metals, as well as decrease mortality. Considering that the “Mad Cow Illness” incident in Europe, using dietary supplements with clear chemical structures such as vitamins to replace “meat and also bone dish” has even more room for advancement. The majority of the VB12 generated worldwide is presently used in the feed market.
- Application in other aspects
In industrialized countries, VB12 and other substances are made use of in cosmetics; in the food market, VB12 can be utilized as a colorant for pork, sausage, gelato, fish sauce and other foods. In domesticity, VB12 remedy is adsorbed on turned on carbon, zeolite, non-woven fiber or paper, or made right into soap, toothpaste, etc; it can be utilized for deodorization of commodes, refrigerators, and so on, and also eliminate the odor of sulfide and also aldehyde; VB12 can also be used Dehalogenation of natural halides, typical contaminants in soil as well as surface area water in environmental protection.
Causes and Diseases of Vitamin B12 Cobalamin Deficiency
- Too little intake
The human body cannot synthesize vitamin B12. Dietary vitamin B12 comes from animal foods, and milk and dairy products contain less vitamin B12. Plant foods basically do not contain vitamin B12. Vegetarians are more prone to vitamin B12 deficiency than non-vegetarians. Vitamin B12 intake was positively correlated with serum vitamin B12 levels. A mother’s vitamin B12 deficiency or insufficient intake may lead to a baby’s vitamin B12 deficiency due to low vitamin B12 levels in breast milk.
Elderly people are prone to vitamin B12 deficiency, and about 60% of them are due to poor absorption of cobalamin bound in food due to gastrointestinal reasons. Taking more than 12-30 μg of synthetic vitamin B12 per day can reduce the risk of low vitamin B12 and high MMA in the elderly. Oral high doses of vitamin B12 can restore the MMA of most vitamin B12-deficient elderly people to normal.
- Intrinsic factor deficiency
Vitamin B12 needs to be combined with intrinsic factor in order to be finally absorbed. Patients with pernicious anemia produce autoimmune antibodies to intrinsic factor, which can lead to severe vitamin B12 deficiency.
Taking antiepileptic drugs, metformin, histamine H2 receptor inhibitors and proton pump inhibitors, hereditary cobalamin II deficiency, tropical sprue diarrhea, Helicobacter pylori infection, parasitic infection, etc., can also lead to vitamin B12 of lack.