Vitamin A1 Retinol CAS 68-26-8

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  • Appearance: Yellow to orange powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Vitamin A1 Retinol Suppiler
68-26-8

Basic Info of Vitamin A1 Retinol

What is Vitamin A1 Retinol?

Vitamin research study is a great achievement in the advancement of life science, while it only took 50 years for human beings to uncover and understand vitamins. However, for researchers at the beginning of vitamin exploration, everything is still extremely difficult. From 1913 to 1915, Elmer McCollum and Marguerite Davis mentioned that there were at the very least 2 various growth elements to keep the growth price: one can be divided from eggs or butter, and also the other can be removed from the multiple neuritis of chickens as well as pigeons. Water use; For that reason, they are named fat soluble vitamin An and also water soluble vitamin B.

In 1919, researchers proved throughout attribute research study that fat soluble vitamin A can not only advertise growth, yet also protect against completely dry eyes and night loss of sight. In 1920, Dr. JC Drummond called this energetic lipid vitamin A. It is located in cod liver oil and also can avoid dry eyes and evening loss of sight.

Vitamin A in body originates from natural food. Natural vitamin A exists in different types. In animal cells, vitamin A exists in the form of vitamin A. However, in plants, the form of vitamin A, called carotenoids, is found in green, orange and also yellow plant cells. Vitamin A compounds in these foods, such as retinol, retinol, carotene, and so on, can be converted into vitamin A in the human body. Therefore, food is the main resource of vitamin A.

As early as 1000 years earlier, the Golden Prescription created by Sunlight Simiao of the Tang Empire taped that animal liver can cure night blindness. This is the early acknowledgment of vitamin A supplements. Standard Chinese medical publications likewise tape-record nourishing the liver and also enhancing the vision. The research study on the treatment of vitamin A deficiency is mostly pertaining to nourishing liver and also kidney, renewing blood significance as well as advertising qi.

Vitamin A1 Retinol Uses

  1. Help with vision loss
    Vitamin A1 retinol has many important functions in the human body. It plays an important protective role on the retina, and has a stabilizing effect on various cell membranes, thereby regulating the permeability of the retina. In vitamin A, retinal acts on vision. Once vitamin A is deficient, retinal will be reduced, and sufficient rhodopsin cannot be synthesized, and night blindness will occur naturally.
    Timely supplementation of vitamin A, our retina will be well protected. Office workers who often use computers should pay attention to protecting their eyesight. In addition to taking regular breaks and paying attention to vitamin A supplementation, it is also very important for the eyes to look far away and do eye exercises.
  2. Respiratory disease timely remedy
    Vitamin A1 retinol can prevent respiratory diseases, and also has a good protective effect on the respiratory tract and gastrointestinal mucosa. Nutrition experts point out that vitamin A supplementation from food is a safe and effective way of health care. The changeable climate in spring will directly affect the defense function of the respiratory mucosa, so vitamin A supplementation is very beneficial to the body.
  3. Effective against cancer
    Vitamin A1 retinol protects against cancer and cardiovascular disease. To prevent cancer, in addition to not smoking, not eating betel nut, not drinking too much alcohol, controlling the intake of salt and fat, but also avoiding the entry of carcinogens into the body, vitamin A supplementation can reduce the toxicity of carcinogens and inhibit the production of free radicals (active oxygen). Regular intake of vitamin A with antioxidant effect, combined with healthy living habits, can effectively reduce the incidence of cancer. Biology believes that the best time to consume vitamin A is 6:00-10:00 am.
  4. Improve memory
    Fast-paced life, high-level work with brains, busy intersections, insufficient rest… Memory is imperceptibly damaged. Some data show that modern women generally suffer from memory loss, insomnia, irritability and other symptoms. Long-term exposure to computers, radiation damages their health. At this time, vitamin A can help you. Actors and musicians are most suitable for vitamin A supplementation. Reciting lines and musical scores requires a lot of mental effort, so sufficient vitamin A must be supplemented. Vitamin A has a very obvious refreshing effect, which can make people sane and clear, and it will be more and more favored by actors and musicians, becoming their darling.

PS: Among animal foods, the content of vitamin A in animal liver, egg yolk and milk is the most abundant. Plant foods contain the most carotene, in addition to carrots, there are alfalfa, spinach, pea shoots, peppers and fruits such as apricots, persimmons, mangoes, etc.

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Application of Vitamin A1 Retinol

Vision as well as Vitamin A. 11-cis-retinal plays an essential duty in pole cells as retinal cone cells and the photogroup of aesthetic pigments. 11-cis-retinal converts to the all-trans retinal form upon light induction. Dissociation of all-trans retina and also opsins paired with neural excitement of the visual center of the mind. Through a collection of biochemical procedures, nerve impulses develop in rod cells at the ends of synapses, as well as the optic nerve after that carries out the nerve impulses out. The visual procedure is a component-renewable cycle in which all-trans retinal can be enzymatically modified to 11-cis under dark conditions.

Systemic effects of vitamin A. Vitamin A not just substantially impacts visual feature, yet also has a greater physiological effect than visual function. Vitamin A shortage interferes with the aesthetic cycle, leads to problems of dark adaptation (evening loss of sight or evening loss of sight), as well as disrupts systemic functions necessary to receive life (eg, corneal damage, infection, as well as hypoplasia). Deficiency of vitamin A can result in animal fatality.

Vitamin A contributes in reproduction and beginning growth. Vitamin A plays an important function in the reproductive process of sperm manufacturing and ovulation, yet its biochemical basis is uncertain. Vitamin A plays a key function in the development of embryos as well as microorganisms and also the maintenance of cells feature. The main body organs impacted by vitamin A shortage are the heart, eye cells, blood circulation system, genitourinary system and breathing system. Vitamin A is necessary for beginning advancement.

Vitamin A contributes in immune function. When animals lack vitamin A, the characteristics of lymphoid body organs, cell distribution, histology, as well as lymphocytes will certainly change. Vitamin A shortage can lead to lowered immune feature, cause swelling, and also exacerbate the symptoms of swelling. Vitamin A plays a role in dermatology. Vitamin A plays an essential role in keeping healthy skin. Vitamin A deficiency can interfere with the terminal distinction of human keratinocytes, resulting in rough, dry, flaky, and also clogged skin.

Vitamin A has been reported to deteriorate epidermal metastases in malignant cancer malignancy as well as T-cell lymphoma, decrease oil secretion as well as microbial numbers in the skin and blood vessels of typical acne, and reduce monocyte as well as neutrophil immune actions. As a vital practical compound in the body system, vitamin A plays a vital role, such as hematopoietic function, bone advancement, lump avoidance, etc. Consequently, vitamin A supplementation is needed for wellness demands.

Preparation of Vitamin A1 Retinol

  • Natural product
    Natural vitamin A is extracted from cod liver oil. Among them, retinol (vitamin A1) is extracted from the liver of marine fish, and 3-dehydroretinol, that is, vitamin A2, is extracted from the liver of freshwater fish.
  • Synthetic
    There are many synthetic routes for retinol and its derivatives, the common one is the Isler route, namely C13-C14-C20.

    Citral and acetone undergo aldol condensation under alkaline conditions to obtain pseudoionone, which is cyclized under the action of sulfuric acid to become ionone, of which β-ionone is C13 referred to in the route. C13 was condensed by Darzens to obtain glycidyl ester, and then hydrolyzed, decarboxylated and rearranged to obtain C14 aldehyde. It is then condensed with Grignard reagent prepared from C6 alcohol to obtain C20, which is the main chain of retinol. After a series of rearrangements, you end up with retinol.

Reference

  1. Vitamin A – WikiPedia
  2. Retinol – PubChem

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