Tranylcypromine Hemisulfate CAS 13492-01-8
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Factory Supply Tranylcypromine Hemisulfate CAS 13492-01-8 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Tranylcypromine Hemisulfate Supplier & Manufacturer
Tranylcypromine Hemisulfate: The Complete Guide
- Item 1: Basic Info
- Item 2: What is Tranylcypromine Hemisulfate?
- Item 3: Tranylcypromine Hemisulfate Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Tranylcypromine Hemisulfate
- Item 6: Preparation of Tranylcypromine Hemisulfate
- Item 7: Quality Control of Tranylcypromine Hemisulfate
- Item 8: Hot Sale Products
- Item 9: Get Tranylcypromine Hemisulfate Quotation
Tranylcypromine Hemisulfate for Sale
Basic Info
Basic Info
Chemical Name: | Tranylcypromine Hemisulfate |
Other Name: | trans-2-PhenylcyclopropylaMine HeMisulfate; Tranylcypromine (hemisulfate); DTNB |
CAS: | 13492-01-8 |
EINECS: | 236-807-1 |
Type: | Pharmaceutical raw materials |
Molecular Formula: | C9H13NO4S |
Molecular Weight: | 231.27 |
Chemical Properties
storage temp. | 15-25°C |
solubility | Soluble in water; very slightly soluble in ethanol (96%) and in ether . |
form | White solid. |
color | White |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Tranylcypromine Hemisulfate MSDS; Tranylcypromine Hemisulfate COA |
What is Tranylcypromine Hemisulfate?
Tranylcypromine sulfonate, (±) – trans-2-phenylcyclopropylaminesulfat (Parnate) is synthesized into amphetamine analogues (visual amphetamine α- Methyl condensation to β- Carbon atom). It does have some characteristics similar to amphetamine, which may be why it has a more direct CNS excitatory effect than drugs that inhibit MAO alone. For MAO inhibition, the effect of the drug may have two components. One is believed to be due to the proximity β- Structural characteristics of transition states in arylamine metabolic pathway (basic nitrogen and α- And β- Quasi π characteristics of cyclopropane carbon atoms). When α- And β- When the hydrogen atom is removed from the normal substrate of the enzyme, the quasi π feature is α,β- Carbon system development. The repetition of the transition state allows very strong, but reversible, attachment to the enzyme.
In addition, trans amphetamine is a mechanism based inactivator. It is metabolized by MAO and one electron of the nitrogen pair is lost to flavin. In turn, this will result in homogeneous fission of cyclopropane carbon bond, in which one electron pairs with the remaining lone nitrogen electrons to form imine (protonation), and the other is located on methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes. One electron from fission pairs with the remaining lone nitrogen electrons to produce imine (protonation), and the other electron is located on the methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes. One electron from fission pairs with the remaining lone nitrogen electrons to produce imine (protonation), and the other electron is located on the methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes.
Tranylcypromine Hemisulfate Uses
- Amphetamine developed by side chain cyclization of amphetamine. This monoamine oxidase inhibitor can efficiently treat severe depression, dysthymia as well as irregular depression. It can additionally be used for panic and also fear.
- Tramcyclopropylamine (13492-01-8) is a permanent and also non discerning monoamine oxidase inhibitor. It has been confirmed to hinder histone demethylase.
- Tranylcypromine (Parnate) is an irreversible monoamine oxidase (MAO) inhibitor.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Tranylcypromine Hemisulfate
In vitro study
Tranylcypromine (10nM to 10 µ M) for human A β (1-42) Oligomer generated toxicity has neuroprotective result and is not affected by glial cells. Tranylcypromine( 100 μ M) It dramatically protects RGC from apoptosis generated by glutamate neurotoxicity as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen activated protein kinase 12 (p38MAPK) under glutamate caused anxiety γ) Expression of. In addition, trans amphetamine can transform p38MAPK γ Task advertises RGC survival.
In vivo study
In computer mice with endometriosis, treatment with tamoxifen substantially as well as dramatically minimized lesion size and boosted systemic hyperalgesia in a dose-dependent manner. Furthermore, anti amphetamine treatment results in lowered immune reactivity to biomarkers such as proliferation, angiogenesis and H3K4 methylation, which results in emergency medical technician stagnancy and also pathological development. Trandecamine (500mM) shot plays a neuroprotective duty in the signal pathway of intracellular apoptosis, prevents the morphological modifications of rat retina, prevents the task of caspase 3 as well as restores p38MAPK in the hurt retina caused by NMDA γ It can boost the survival rate of RGC after retinal injury by lowering the neurotoxicity of NMDA. As detected by BrdU immunohistochemistry, tamoxifen (10 µ g/g) led to an approximate and also substantial increasing of classified cells in the joint mind areas taken a look at. The maximum boost of cerebellar cell expansion was induced by tamoxifen.
Preparation of Tranylcypromine Hemisulfate
Amazing the option having 167 g of stable styrene and 183 g of ethyl diazoacetate to 0 ° C, and decline 83.5 g of styrene under mixing at 125 ° to 135 ° C in a dry nitrogen ambience. This provides the ester ethyl 2-phenylcyclopropane carboxylate.
Reflux the above ester (207.8 g) and also 64.5 g sodium hydroxide solution in 80 ml water and also 600 ml ethanol for 9 hrs. The carboxylic acid of 2-phenylcyclopropane is launched by 200cc focused hydrochloric acid. 2-Phenylcyclopropane carboxylic acid has 3-4 trans isomers as well as 1 cis isomer. Acid recrystallizes from hot water. Pure trans isomers take place as crystalline compounds (solids), while cis isomers continue to be in solution. 4.62 g of 2-phenylcyclopropane carboxylic acid solution in 15 cc of anhydrous benzene was refluxed with 4 cc of thionyl chloride for 5 hours to eliminate unpredictable liquid, and also the residue was distilled with benzene again. Fractionation of the residue returns carbonyl chloride of 2-phenylcyclopropane.
A mixture of 15 g of industrial salt azide and also 50 ml of anhydrous toluene was stirred and warmed, and then 10 g of 2-phenylcyclopropane carbonyl chloride option in 50 ml of anhydrous toluene was slowly included. Filter the inorganic salt as well as clean it completely with anhydrous benzene to remove the solvent under lowered stress. The resulting RCON3 compound was repositioned into RNCO+N 2 with Curtius. The residual isocyanate is a clear red oily substance with particular odor. It was cooled to 10 ° C and also thoroughly treated with 100 cc of 35% hydrochloric acid, where RNCO+H 2O generated RNH2+CO2. After most of the launch of co2 has actually decreased, the mixture is refluxed for 13 hrs, the cooled solution is diluted with 75 cc of water and removed with three 50 cc parts of ether.
Awesome the virtually completely dry residue to 0 ° C as well as adjust it to solid alkalinity with 50% potassium hydroxide remedy. Remove amine right into numerous sections of ether, dry with potassium hydroxide, remove solvent, and also fractionate alkali. Alkali reacts with half a mole of sulfuric acid to form sulfate.
Reference
Tranylcypromine sulfate – PubChem
Tranylcypromine Hemisulfate Suppliers and Manufacturers
As a tranylcypromine hemisulfate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best tranylcypromine hemisulfate raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for tranylcypromine hemisulfate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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Pre-Sales Service
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* Every batch of products will be tested to ensure its quality.
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After-Sales Service
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* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Tranylcypromine Hemisulfate
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