Tranexamic acid // Tranexamic acid powder 99% // Tranexamic acid powder 99% with lower price 1197-18-8

Basic Info

Model No.: LYN- 1197-18-8

Shelf Life: 2 Years

Form:: Powder

CoA: Available

Sample: Free

CAS: 1197-18-8

Name:: Tranexamic Acid

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

Port: Shanghai,Tianjin,Qingdao

Product Description

Tranexamic acid // Tranexamic acid powder 99%  // Tranexamic acid powder 99% with lower price 1197-18-8 

Introduction: 

                    

Product name: Tranexamic Acid

-CAS No.1197-18-8

-EINECS No.214-818-2

-Molecular formula: C8H15NO2

-Molecular weight: 157.21

-Purity: 99%~101% Tranexamic acid

-Appearance: White or almost white, crystalline powder

-Brand: zhishang

Tranexamic acid is a synthetic derivative of the amino acid lysine.Tranexamic acid (commonly marketed in tablet form as Lysteda and in IV form as Cyklokapron in the U.S. and as Transamin,Transcam in Asia, and Espercil in South America) is often prescribed for excessive bleeding.

 

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is the basic framework for the formation of a blood clot in hemostasis.Tranexamic acid has roughly 8 times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.

 

Application:

Tranexamic acid is frequently used in surgeries with high risk of blood loss such as cardiac, liver, vascular and large orthopedic procedures. Its oral form is now being evaluated for use in outpatient conditions involving heavy bleeding.
Trauma
Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma. However, it may actually increase the risk of death due to bleeding if administered more than 3 hours after the injury. 
Heart surgery
Tranexamic acid is commonly used in cardiac surgery, both with and without cardiopulmonary bypass. It replaces aprotinin.
Orthopedic surgery
Tranexamic acid is used in orthopedic surgery to reduce bloodloss. It is of proven value in clearing the field of surgery and reducing pre- and postoperative blood loss. Drain and number of transfusions are reduced. However, the hidden blood loss is not reduced. Still, it is becoming an important tool in the anaesthetist’s arsenal. It is commonly used in joint replacement surgery.
Menstrual bleeding
Used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. A recent study showed patients treated with tranexamic acid are more likely to develop thrombosis and necrosis in their fibroids, and may result in pain and fever. Moreover, the histological appearance of the necrosis in women treated by tranexamic acid is no different from the spontaneous incidence of thrombosis. The U.S. Food and Drug Administration (FDA) approved tranexamic acid oral tablets  for treatment of heavy menstrual bleeding on 13 November 2009.
Dentistry
Tranexamic acid is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time, e.g. from acquired or inherited disorders.
Other uses
In obstetrics, tranexamic acid is used after delivery to reduce bleeding, often with syntocinon/oxytocin and fundal massage. A major trial is in progress worldwide to establish the efficacy of the drug to arrest postpartum haemorrhage (PPH). Since the drug can be administered orally, it has great potential to reduce maternal mortality rates in developing countries where primary healthcare is often unavailable.

In cardiac surgery, e.g. coronary artery bypass surgery, it is used to prevent excessive blood loss. 

In hemophilia – Tranexamic acid is also useful in the treatment of bleeding as a second line treatment after factor VIII in patients (e.g. tooth extraction).
Whitening effect
Clinical studies for years have proved that tranexamic acid can dilute spot effectively and rapidly, which helps to demonstrate a perfect white and bright skin. The spot-removing effect of tranexamic acid is about 50 times over Vitamin C, and 10 times over AHA. The concentration limit of usage is 2%-3%, and in cosmetics the amount is around 0.5%.

 

Specification:

 

Test  Item

Analysis  Specification

Result

Description

White crystalline powder

 

Conform

Identification

IR test

 

Conform

PH

7.0~8.0

7.4

Related substances

Liquid chromatography

 

ImpurityA ≤0.1%

ImpurityB≤0.2%

Any other impurity≤0.1%

All other impurity≤0.2%

 

≤0.005%

≤0.05%

<0.1%

<0.2%

<0.1%

<0.2%

 

Loss on drying

≤0.5%

0.3%

Residue on ignition

≤0.1%

<.08%

Heavy metals

≤10ppm

<10ppm

Chlorides

≤14ppm

<140ppm

Sulphated ash

≤0.1%

<0.1%

Assay

99.0%~101.0%

99.76%

Conclusion

Complies to BP2007

 

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