Tocopheryl Acetate CAS 7695-91-2 VitaMin E Acetate
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- Appearance: Light yellow liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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Tocopheryl Acetate: The Complete Guide
- Item 1: Basic Info of Tocopheryl Acetate
- Item 2: What is Tocopheryl Acetate
- Item 3: Tocopheryl Acetate Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Tocopheryl Acetate
- Item 6: Preparation of Vitamin E
- Item 7: Quality Control of Tocopheryl Acetate
- Item 8: Hot Sale Products
- Item 9: Get Tocopheryl Acetate Quotation
Tocopheryl Acetate for Sale
Basic Info of Tocopheryl Acetate
Basic Info
Chemical Name: | Tocopheryl Acetate |
Other Name: | VitaMin E acetate; alpha tocopheryl acetate; di alpha tocopheryl acetate; dl alpha tocopherol acetate; vitamin e tocopheryl acetate |
CAS: | 7695-91-2 |
EINECS: | 231-710-0 |
Type: | Food additives; Feed additives; Pharmaceutical raw materials; Cosmetic raw materials; Plant extracts |
Molecular Formula: | C31H52O3 |
Molecular Weight: | 472.74 |
Chemical Properties
Melting point | -28°C |
Boiling point | 224 °C0.3 mm Hg(lit.) |
density | 0.96 g/mL at 20 °C (lit.) |
vapor density | 16.3 (vs air) |
refractive index | n20/D 1.497 |
Fp | >230 °F |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils. |
form | neat |
color | Clear yellow viscous liquid |
Specific Gravity | 0.962 (20/4℃) |
Odor | Odorless |
Water Solubility | Immiscible with water. |
Sensitive | Air & Light Sensitive |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Tocopheryl Acetate MSDS; Tocopheryl Acetate COA |
What is Tocopheryl Acetate?
Tocopheryl acetate is a yellow-colored or yellow transparent thick fluid, almost odorless, and it is conveniently oxidized when revealed to light. Vitamin E contains numerous functions that can promote numerous aspects of human health, as well as it is widely utilized in a range of individual treatment as well as health items.
Tocopheryl acetate is both a skin conditioner and also an antioxidant, and also when used as an aesthetic ingredient, it has safety impacts such as protecting against damages to the skin from the sun’s ultraviolet rays. Additionally, it can be absorbed the form of a vitamin supplement.
Tocopheryl acetate has substantial anti-oxidation, elimination of totally free radicals in the body, prevention of cancer, improvement of immunity and other features, as well as is a vital vitamin in human life tasks. Nonetheless, because the six-position hydroxyl team on the chroman ring of vitamin E is conveniently oxidized to form the corresponding quinone, the vitamin E quinone no more has the organic task of vitamin E. Esterification of vitamin E can prevent the oxidation of vitamin E, boost the stability of vitamin E items, as well as additionally resolve the trouble of poor water solubility as well as enhance its surface area activity.
Tocopheryl Acetate Uses
- Vitamin E has the impact of preventing the oxidation of cell membranes and intracellular unsaturated fats and other very easy oxides in the body’s metabolic process, consequently shielding the honesty of cell membranes and also protecting against aging, and also can maintain the typical function of reproductive organs.
- Vitamin E has strong reducibility and also can be made use of as an antioxidant to eliminate totally free radicals in the body and also decrease the damages of ultraviolet rays to the human body.
For skin treatment, hair treatment, and so on. - Utilized as ingredients in medications, nutritional products as well as cosmetics.
- After vitamin E ends up being vitamin E acetate, it has various other unique effects. For instance, vitamin E acetate can be used to prepare medicines for the therapy of oral mucosal dryness, vaginal dryness and itching, anal, nasal and eye mucosal abscess, dental mucosal ulcers. swelling, glossitis, keratoconjunctivitis, keratitis, corneal pain, corneal ulcer, corneal deepithelialization, capsular rhinitis, nasal vestibulitis, atrophic vaginitis, etc.
- Vitamin E has solid reducibility, has anti-oxidation and anti-aging results in the process of human metabolism, as well as can maintain the normal function of reproductive organs. Generally, DL-vitamin E can be utilized as a nutritional fortifier, as well as can also be strengthened with D-α-tocopherol, D-α-tocopherol acetate or DL-α-tocopherol, and also the dose has to be transformed.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Tocopheryl Acetate
Natural vitamin E, also known as tocopherol, includes 4 kinds, among the various forms of vitamin E compounds, A-tocopherol) has the highest biological activity. Therefore, tocopherol acetate prepared from natural tocopherol is the most active vitamin E derivative. Its biological activity is three times that of synthetic vitamin E, and it has no chemical pollution and no toxic and side effects on the human body, ensuring the effectiveness of the material. The ingredients are not destroyed, maintaining the pure natural quality of the product. Natural tocopherol acetate has the advantages of high physiological activity, rich nutrition, safety and reliability, and conforms to the trend of human beings to strengthen nutrition, return to nature, and safe consumption, and has been used more and more to replace synthetic vitamin E.
Tocopherol acetate is an essential ingredient for human nutrition, and has significant functions such as anti-oxidation, elimination of free radicals in the body, prevention of cancer, and pre-improvement of immunity. As a feed additive, it can improve the reproductive function of animals and increase fecundity. In the food industry, it is mainly used as an antioxidant and nutritional fortifier for oily foods; in the pharmaceutical industry, it can be used as a pharmaceutical raw material for the production of finished medicines, and is useful for the treatment of periodontitis, pachydermia, fatty liver, arteriosclerosis, high cholesterol It has good effects on blood circulation, etc. It can be used in cosmetics to delay skin aging, increase skin elasticity, restore youthful vitality, moisturize the skin, and maintain skin moisture.
In fact, a large part of the use of tocopherol is achieved with tocopherol acetate. In addition, the natural only tocopherol (or natural tocopherol) produced by some manufacturers is actually its acetate, and the so-called tocopherol is actually tocopherol acetate. Due to the large molecular weight of tocopherol and a longer side chain, it is fat-soluble. This brings unfavorable factors to the products used in feed additives, medicines, food, cosmetics and so on.
When used as a feed additive, it is easy to oxidize, which affects its activity; when used as a drug, because it cannot dissolve in water-soluble media, its application in intravenous injection is limited. This is due to the “allogenic response” in the muscle due to the presence of the oily carrier. When used as a cosmetic, it can only be made into a milky form because it cannot be miscible with water-soluble active ingredients. Such products often have poor surface activity, making it difficult to exert the physiological effects of their active ingredients. The synthesis of water-soluble tocopheryl acetate compensates for these deficiencies. Compared with free tocopherol, tocopherol acetate products have many application advantages in medicine, cosmetics, food and feed.
Preparation of Vitamin E
Preparation of Natural Vitamin E
Extraction
The low-carbon alcohol of C1-C4 or the mixture of alcohol and ketone containing (5%-15%) low-carbon ketone of C3-C5 is used as an extracting agent to extract from vegetable oil. For example, add 50 mL of methanol to 100 g of crude palm oil, shake and extract at 45 °C, take the methanol phase to freeze overnight at -10 to -20 °C, filter to remove the precipitated sterols and fatty acid crystals, and distill the mother liquor to remove methanol to obtain vitamin E. Concentrated, the content is 11%.
Esterification
The deodorized distillate in the oil and fat deodorization process is used as a raw material, the fatty acid therein is esterified with a polyhydric alcohol, and the ester is removed by steam distillation to obtain a concentrate.
For example, 1000g soybean oil deodorized distillate (acid value 68.8, saponification value 133, iodine value 152) was added with glycerol with an equivalent acid value of 1.1 times (41.4g), and refluxed with xylene (240°C) until the acid value decreased. To 0.5, after removing the solvent, the esterified product was distilled with steam (at 400Pa), the acid freed in the distillation process was esterified with glycerol, and finally distilled to obtain a concentrate with a content of 56.3% and a yield of 64.8%.
Saponification, enzymatic and other methods can also be used.
Synthesis of DL-vitamin E
7.8g of 2,3,5-trimethylhydroquinone, 6.8g of anhydrous zinc chloride and 1mL of glacial acetic acid were added to a mixed solvent of 20mL of dichloromethane and 5mL of diisopropyl ether, and stirred uniformly at room temperature; 15.6 g of 95% isophytol was added dropwise within 3 h, and then stirred for 30 min after the dropping; after the reaction, the solvent was removed under reduced pressure, and the obtained reddish brown oil was dissolved in 150 mL of hexane, followed by 2% NaOH solution. It was washed with saturated brine, dried with Glauber’s salt, and then the solvent was removed under reduced pressure to obtain 22.1 g of red-orange oily crude tocopherol with a yield of 99% and a purity of 95%.
The crude product was treated with molecular distillation to obtain 18.9 g of colorless oily refined tocopherol, with a yield of 88%. Dissolve 25 g of the above product in 50 mL of acetic anhydride, add 12.5 g of sodium acetate and 1.25 g of sodium metal, and stir at 90-100 °C for 3.5 h. After acetylation, 200 mL of hexane was added for extraction, and the extract was washed successively with 1% NaOH solution, water and saturated brine. After dehydration with magnesium sulfate, hexane was removed to obtain 26.2 g of crude vitamin E acetate. The crude product was vacuum distilled, and the fractions at 165-170°C were collected to obtain 20.5 g of vitamin E acetate with a purity of 97.3% and a distillation yield of 78.0%.
Reference
- DL-alpha-Tocopherol acetate – PubChem
- Zheng Yansheng, Su Hui, Li Junsheng, et al. Study on synthesis of vitamin E acetate catalyzed by triethylamine[J]. Journal of Guangxi Institute of Technology, 2006, 17(3): 33-35.
- Li Juan, Yao Yuni. Vitamin feed additive-α-tocopherol acetate (vitamin E acetate)[J]. China Feed Additives, 2012 (3): 17-19.
Quality Control of Tocopheryl Acetate
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