Retinoic Acido CAS 302-79-4
Factory Supply Retinoic Acido CAS 302-79-4 with Best Price
- Appearance: Yellow powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Retinoic Acid Supplier & Manufacturer
Retinoic Acido: The Complete Guide
Retinoic Acido for Sale
Basic Info of Retinoic Acido
Retinoic acid; Retinoic; Vitacid retinoic acid; Retinoic acido; Retinoic acid tretinoin; Retinoic acido bassa
Pharmaceutical raw materials
What is Retinoic Acido?
Retinoic acido is a commonly used drug in dermatology. It is the metabolic intermediate product of vitamin A (vitamin methanol) in the body. It mainly affects the growth of bone and epithelial metabolism, can promote the proliferation and renewal of epithelial cells, and can inhibit the proliferation and differentiation of keratinocytes. It can restore the hyperkeratosis to normal, so it has a certain therapeutic effect on many diseases with complete keratinization, incomplete keratinization and hyperkeratosis, and can treat a variety of skin diseases.
Topical application of retinoic acido penetrates the skin quickly and can significantly increase epithelial cell turnover. In addition, this product also has anti-tumor, promoting wound healing and anti-infection effects.
Retinol, retinal, and retinoin are all used in skin care products to simulate the role of retinoic acid (retinoic acido, also known as all-trans retinoic acid). They will eventually be converted into retinoic acido, so the effect of retinoids is actually similar. However, the stimulation of retinoic acid directly is relatively large, so the common ingredients in skin care products are retinol and retinoid.
Retinoic Acido Uses
- Retinoic acido is mainly suitable for the treatment of psoriasis, ichthyosis, keratosis pilaris, acne, lichen planus, verrucous epidermal nevus, subcorneal impetigo, vitiligo, pityriasis rubra pilaris and pityriasis simplex on the face, etc. . In addition, it also has a certain preventive effect on skin cancer.
- Retinoic acido for abnormal acne, ichthyosis as well as irregular psoriasis.
- Anti-keratosis medicines.
- Retinoic acido likewise called retinoic acid, retinoic acid, this item is the metabolic intermediate of vitamin A in the body, which mostly impacts the growth of bone and also the metabolism of epithelial cells, and has the results of advertising epithelial cell spreading and also keratin dissolution.
- Retinoic acido can additionally be made use of as an adjuvant therapeutic drug for psoriasis (psoriasis), and also can also be made use of to treat multiple typical warts as well as various skin diseases such as ichthyosis, follicular keratosis, and so on.
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Action Mechanism of Retinoic Acido
Retinoic acido medications exert their pharmacological results via retinoic acid receptors. The successful growth of receptor-selective retinoic acid as well as its scientific application is among the success of this research study.
Retinoic acido receptors come from a subfamily of the nuclear receptor superfamily, which likewise consists of steroid, vitamin D and also thyroid hormone receptors and also peroxisome proliferator-activated receptors, insect ecdysteroid receptors. receptors and numerous orphan receptors whose ligands are unknown.
Retinoic acido can increase the DNA synthesis as well as mitotic index of skin cells by regulating the mitogen impact of skin development factor, generate skin hyperplasia, as well as thicken the granular layer as well as the spinous cell layer.
An additional vital function is to advertise the distinction of epidermal granular layer cells to the stratum corneum by influencing K1, K10 keratinase hydrolysis, impacting the process of filaggrin to filaggrin and the development of cross-linked envelope in the later stage of epidermal cell distinction.
Its activity on melanocytes is multi-site, and it has repressive impacts on the tasks of three sorts of catalytic enzymes such as tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase, consequently decreasing melanin formation as well as skin coloring. It has no result on normal human melanocyte tyrosinase activity and melanin structure.
Retinoic acido can extend the maturation process of basal cells of sebaceous glands, decrease the variety of sweat glands, and lower the proportion of proliferating cells in sebaceous glands, leading to minimized sebum synthesis.
It can hinder the movement of neutrophils, prevent the manufacturing of arachidonic acido and also its metabolites, hinder the production of leukotrienes and also oxide anions by neutrophils, and prevent the launch of lysosomes.
It influences both humoral resistance as well as mobile immunity. Reduced dosages have immunostimulatory impacts, while low and high doses have immunosuppressive effects. It can boost the variety of Langerhans cells in the skin and prevent lymphocyte expansion.
Retinoic acido can remedy or avoid the irregular biochemical structure and also morphological structure of facial connective cells triggered by harmful factors such as ultraviolet radiation, promote the synthesis of extracellular matrix healthy protein in the skin, and also increase the development of brand-new connective cells bands in the top dermis.
The Preparation Method of Retinoic Acido
93g of triethyl phosphite was put into the three-necked flask, the temperature was raised to 100°C, 55g of methyl chloroacetate was added dropwise, and the reaction was refluxed for 2h after the dropwise addition. 105 g of phosphonate (methyl diethylphosphinoacetate) were obtained.
After cooling to room temperature, add 400 mL of n-heptane and 60 g of acetal acetal, and add 250 g of sodium methoxide/methanol solution with a concentration of 15% dropwise to maintain the temperature below 0 °C. Wash twice with 300mL/time of water.
At room temperature, 250 mL of 10% dilute hydrochloric acid solution was added dropwise to the organic layer, stirred for 2 h after the drop was completed, and after the hydrolysis was detected by HPLC, the layers were left to stand for stratification, and the organic layer was washed twice with 300 mL/time of water.
Fig. 1 is the synthesis of C5 aldehyde ester
- Retinoic acid – ChemicalBook
- Tretinoin – PubChem
- You Yi, Hao Fei. Classification and pharmacological effects of retinoic acid [J]. Dermatology and Venereal Diseases, 2018, 40(01): 25-26.
- Zhang Mingfeng, Liu Xianghong, Chen Gang, Zhang Qin.Synthesis of all-trans retinoic acid[J].Guangzhou Chemical Industry,2015,43(05):92-94.
Retinoic Acido Supplier and Manufacturer
As a retinoic acido supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best retinoic acido raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for retinoic acido and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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