Pyrrolidine CAS 123-75-1

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  • Appearance: Colorless liquid
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Pyrrolidine Supplement
123-75-1

Basic Info of Pyrrolidine

What is Pyrrolidine?

Tetrahydropyrrole is a cyclic secondary amine. Appearance is anemic and clear liquid with unique smell. It turns yellow when exposed to light or humid air. It is quickly soluble in water and also ethanol, and is corrosive and combustible. It has the homes and also responses of basic amines. It has a vast array of applications in the fields of medication, food, pesticides, daily chemicals, coatings, textiles, printing as well as dyeing, papermaking, photosensitive materials, polymer materials, desulfurizing representatives, and also zeolite template materials.

Pyrrolidine is a cyclic amine with five membered ring consisting of four carbon atoms as well as one nitrogen atom; Parent compound of pyrrolidine household. It belongs to saturated natural heteromonocyclic moms and dad, pyrrolidine as well as azacyclone. It is a conjugate base of pyrrolidine ions.

Pyrrolidine is a sort of biography unpredictable amine with nicotine like synaptic impact on the nerves. Pyrrolidine degrees in cells were checked out by using mass debris imaging methods. High concentrations of pyrrolidine were located in bunny seminal vesicles and also lungs. Just trace quantities of pyrrolidine were present in computer mouse and also rat brain, while greater concentrations of pyrrolidine were detected in bunny mind. Nonetheless, in the rat mind, high degrees of pyrrolidine were found in the pineal gland, pituitary gland and striatum.

Pyrrolidine Uses

  1. Tetrahydropyrrole has the residential or commercial properties as well as reactions of basic amines. It has a variety of applications in the fields of medication, food, pesticides, everyday chemicals, finishings, fabrics, printing as well as dyeing, papermaking, photosensitive materials, polymer products, desulfurizing representatives, as well as zeolite theme substances.
  2. Pyrrolidine is a kind of combustible and alkaline liquid, which can generate typical secondary amine reaction. It is utilized in the preparation of pesticides and rubber accelerators and also as a chemical intermediate (typically in the form of hydrochloride) in the pharmaceutical industry. Industrial direct exposure of this product is reasonably restricted.
  3. A heterocyclic compound utilized as a part in the synthesis of a selection of pharmaceutical substances, specifically, matrix metalloproteinase inhibitor (MMPI) and aminopeptidase N inhibitor (apni).
  4. Pyrrolidine is virtually specifically made use of in the synthesis of medications, consisting of anti-biotics. Furthermore, it is additionally utilized to generate vulcanization accelerator.
  5. Various modifications of pyrrolidine exist in nature and synthetic chemistry. Many natural alkaloids, such as nicotine, hygrine, atropinone, proline, etc., have pyrrolidine ring as substructure in their molecular structure.
  6. Pyrrolidine exists in alcoholic beverages and is distributed in trace amounts in bread, milk, cheese, carrots, beer and caffeine. Its presence in food may be due to the decarboxylation of the carboxyl group of proline by bacteria. It also exists in various clinically used drugs and drugs. Pyrrolidine has been found to have free radical scavenging, anti-inflammatory, anti-tumor, liver protection and metal chelating properties.

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Application of Pyrrolidine

Heterocyclic substances are extensively dispersed in nature and also play a vital role in the metabolic rate of all living cells. Lots of natural as well as artificial heterocyclic compounds have pharmacological activities and have actually been used in facility. Pyrrole is extensively made use of in medication, farming chemicals as well as veterinary medicine. They can additionally be utilized as anti-oxidants, developers, sensitizers, rust inhibitors and copolymer dyes. They have actually been used as forerunners for the synthesis of essential natural items. Reserpine is an indole alkaloid that has been made use of to deal with psychotic behavior and control high blood pressure. Agimalin as well as strychnine are indole alkaloids. The previous is used as an antiarrhythmic agent and also the latter is an extremely poisonous chemical. Shifang clam contaminant, a neurotoxin, is an all-natural aquatic item.

Preparation of Pyrrolidine

  1. Take 1,4-butanediol as raw material, dehydrate it to create tetrahydrofuran, and afterwards react with ammonia to obtain pyrrolidine.
  2. Utilizing furan as resources, under the action of a catalyst, react with ammonia at 400 ° C to get tetrahydropyrrole.
  3. Using 1,4-dichlorobutane as basic material and responding with ammonia, pyrrolidine can be obtained.
  4. Using pyrrole as resources as well as ruthenium or rhodium as driver, decrease can be made to get tetrahydropyrrole.

Reference

  1. Pyrrolidine – PubChem
  2. What is Pyrrolidine?  – ChemicalBook
  3. Application of Pyrrole – ChemicalBook

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