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Vitamin B6 CAS 8059-24-3 Pyridoxine

Factory Supply Pyridoxine Hydrochloride CAS 8059-24-3 Vitamin B6 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Vitamin B6 Supplier & Manufacturer

Basic Info of Vitamin B6

What is Vitamin B6?

Vitamin B6 is also referred to as the “anti-dermatitis vitamin”. One of the B vitamins. It is a pyridine by-product, consisting of 3 substances, pyridoxine, pyridoxal, and pyridoxamine, which can be exchanged each other and have the effect of vitamin B6. These 3 kinds are present in low focus in egg yolks, meat, fish, milk, grains, seed husks, beans, cabbage, and also other veggies. Human intestinal tract microorganisms can additionally synthesize vitamin B6, which is bountiful in yeast, liver, grains, meat, fish, eggs, beans and also peanuts.

Vitamin B6 is extensively found in nature, egg yolk, fish, meat, seeds, as well as grains (bacterium) are abundant, and also the general diet will certainly not lack this vitamin. Absence of vitamin B6, can cause dermatitis, aches, anemia as well as various other signs and symptoms. Vitamin B6 is primarily utilized in maternity, radiation illness and also throwing up caused by anticancer medications, vitamin B6 shortage, seborrheic dermatitis, cheilitis, angular cheilitis and also intense and chronic eczema, and so on. It can also be made use of in food fortifiers, feed additives as well as cosmetics.

Vitamin B6 (pyridoxine). This vitamin, rarely called ademin or pyridoxine, is involved in protein, carbohydrate and lipid metabolism. Vitamin b6 is essential for the production of antibodies and red blood cells, which is very important for the brain and nervous system development of infants. The main function of this drug is to prevent and treat peripheral neuritis caused by long-term use of isoniazid; Reduce nausea, vomiting and pregnancy vomiting caused by radiation adjuvant drugs; Assist infants with convulsions or give them to pregnant women to prevent infant anemia; It can be used as an assistant for giant cell anemia; Topical vitamin b6 ointment can help acne, rosacea, seborrheic rash.

Vitamin B6 Uses

Because vitamin B6 can break down healthy protein into crucial amino acids for the body to advertise the activity of enzymes. Consequently, an antibody can be developed in the body to keep the regular function of immune feature and avoid the incident of different neurological and skin diseases as well as allergic reactions.

Vitamin B6 has a specific auxiliary result on female physical illness. Consequently, vitamin B6 is likewise referred to as the “females’s vitamin”. It can not only regulate the secretion of women estrogen, however also promote the metabolism of corticosteroids, consequently slowing down the “premenstrual tension disorder” caused by the imbalance of female hormone secretion prior to menstrual cycle.

Not only that, vitamin B6 can also get rid of troubles such as mental illness and also irritability in menopausal women; it also has a great easing result on ladies’s physical duration pain or discomfort, and females’s knuckle discomfort during pregnancy; it can additionally stop menopause. Bone spurs or nodules expand around the hands and feet of ladies, and symptoms such as raised metabolic process in ladies after oral contraceptive pills.

In addition, vitamin B6 can additionally promote the synthesis of nucleic acid and also stop the aging of cells as well as body organs.

Taking a total amount of 60 mg of vitamin B6 3 times a day can likewise efficiently improve the mindset and also has a good auxiliary impact on people dealing with depression.

If vitamin B6 is taken along with vitamin B11 as well as vitamin B2, it can aid early cardiovascular disease brought on by it, but it should be kept in mind that the dosage ought to not surpass 250 mg daily.

  1. Pyridoxine hydrochloride is used for lung as well as spleen deficiency disorder. This item can reinforce the spleen and replenish qi, and is a generally made use of medication for the therapy of lack of lung and spleen qi, such as loss of appetite, tiredness, lightheadedness, nausea and also throwing up, muscle mass degeneration and softness, as well as skin feeling numb.
  2. Pyridoxine hydrochloride is used for palpitations and insomnia. This product can nurture the heart as well as calm the nerves, and is often made use of to deal with palpitations, uneasyness, sleep problems, pins and needles of hands and feet triggered by weak qi and also blood, and heart failure.

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Application of Vitamin B6

Vitamin B6, alias pyridoxal, pyridoxine. It is an auxiliary component of amino acid decarboxylase and transaminase in protein metabolism.

The main clinical applications are: vitamin B6 deficiency, infant convulsions, anemia caused by hemoglobin deficiency, nausea and vomiting caused by some anticancer drugs; prevention and treatment of peripheral neuritis, insomnia, and restlessness caused by isoniazid and other drugs.

With the deepening of clinical application, the clinical indications of vitamin B6 continue to expand. As an auxiliary drug, vitamin B6 can be regarded as a god assist in medicine.

Azithromycin is a commonly used antibiotic for a variety of respiratory infections, but is often limited by its associated severe gastrointestinal side effects.

But azithromycin in combination with vitamin B6 can reduce its side effects.

Reason for combination

Azithromycin is a motilin receptor agonist that stimulates the gastric antrum and small intestine to produce similar physiological contractions, disturbs gastrointestinal motility, causes nausea, vomiting, and abdominal discomfort. By stimulating the release of acetylcholine in the gastrointestinal plexus, it increases gastrointestinal motility, causing abdominal pain, diarrhea, and loose stools.

Vitamin B6 is converted into pyridoxal phosphate in red blood cells, which can catalyze glutamate as a coenzyme. It can act on the vomiting center, thereby clearing or reducing gastrointestinal reactions.

At the same time, vitamin B6 is also involved in the conversion of tryptophan into niacin or serotonin, which can treat nausea, vomiting, and reduce intestinal allergy. And inhibit the release of acetylcholine, inhibit gastrointestinal motility, relieve gastrointestinal smooth muscle spasm.

Clinically, vitamin B6 combined with azithromycin is often used to treat children with mycoplasma pneumonia, and vitamin B6 can reduce the gastrointestinal reactions in children.

Primary dysmenorrhea refers to lower abdominal pain, bloating and other discomforts that occur during menstruation when there is no organic disease in the reproductive organs.

Vitamin B6 can be combined with desogestrel, ethinyl estradiol or progesterone in the treatment of primary dysmenorrhea.

Reason for combination

Vitamin B6 can increase the concentration of magnesium ions in uterine muscle cells, reduce the stimulation of muscle cells to external active substances, and make uterine muscles relax.

In addition, vitamin B6, as a coenzyme, participates in the synthesis of aminobutyric acid, which is a central nervous system inhibitory transmitter, and an increased content can cause muscle relaxation and reduce uterine smooth muscle tension.

Treating PMS
Premenstrual syndrome refers to the recurrent and periodic physical and mental symptoms that occur before menstruation, usually 7 to 14 days before menstruation. It also includes behavioral discomfort, such as insomnia, nervousness, restlessness, irritability, depression, breast tenderness, headache, loss of libido, etc., which seriously affects the life and work of the majority of women.

Clinically, fluoxetine can be used in combination with vitamin B6 to treat premenstrual syndrome.

Vitamin B6 can play a role in reducing the symptoms of premenstrual syndrome by promoting the body’s metabolism, regulating the autonomic nervous system, and inhibiting the synthesis of prolactin.

Hyperemesis gravidarum refers to frequent nausea and vomiting in early pregnancy and inability to eat, which can cause acidosis, water and electrolyte disorders, damage to liver and kidney function, affect the normal development of the fetus, and even cause pregnancy termination and threaten the life of pregnant women.

Clinically, procaine combined with vitamin B6 is used to treat hyperemesis gravidarum.

Reason for combination

Procaine may regulate gastrointestinal motility, relieve nausea and vomiting, and inhibit uterine contractions by inhibiting serotonin, regulating autonomic function, and blocking pathological impulses.

Vitamin B6 generates physiologically active pyridoxal phosphate and pyridoxine phosphate through enzymatic action in the body. It is the coenzyme of some amino acid transferases in the body and participates in many metabolic processes in the body.

It not only increases the production of the inhibitory neurotransmitter 7-aminobutyric acid in the brain, but also participates in the conversion of linoleic acid to arachidonic acid, which can increase the formation of PGl2. 7-aminobutyric acid is an important inhibitory transmitter in the central nervous system. PGl2 has a certain effect on promoting gastrointestinal smooth muscle peristalsis and regulating metabolism.

However, it is necessary to control the intensity of stimulation when using it. Excessive stimulation may cause uterine contractions and miscarriage, so caution should be used in clinical use.

Hand, foot and mouth disease in children is caused by viral infection. The main pathological changes are oral herpes, ulcers, inability to eat, severe pain, and herpes on the hands, soles, buttocks, and knees.

Based on the above characteristics, in addition to anti-inflammatory and antiviral treatment, vitamin C and vitamin B6 injections can also be used intravenously to assist in the treatment of children with hand, foot and mouth disease.

Vitamin C participates in oxidation and reduction reactions in the body, is necessary for the synthesis of collagen and interstitial cells, reduces the permeability of capillaries, accelerates blood coagulation, reduces blood lipids, increases resistance to infection, and promotes granulation tissue growth and wound healing , involved in detoxification.

And vitamin B6 has a sedative effect on the central nervous system, reduces gastrointestinal reactions, and can also promote the healing of oral ulcers.

The synergistic effect of the two speeds up the healing of oral ulcers, and also promotes the healing of rashes on hands, feet, buttocks and knees.

Vitamin B6 Deficiency

Vitamin B6 deficiency includes two types of vitamin B6 deficiency and vitamin B6 dependence. In a narrow sense, vitamin B6 deficiency refers to a disease caused by insufficient intake of vitamin B6 from food or by taking certain drugs to inactivate vitamin B6. Vitamin B6 dependence refers to patients who consume the amount of vitamin B6 required by healthy people, but still have vitamin B6 insufficiency, which is mostly a hereditary disease. With a normal diet, vitamin B6 deficiency is rare. At present, most of the vitamin B6 deficiency seen clinically is caused by taking vitamin B6 antagonists such as isoniazid, cycloserine, penicillamine, etc.; a few are caused by malignant tumors, severe liver and kidney diseases, and chronic alcoholism; Improperly fed babies and elderly people with poor appetite can also get sick. 

Main clinical manifestations: skin and mucous membrane inflammation, common seborrheic and desquamative dermatitis, stomatitis, glossitis, ophthalmia, etc. Followed by mental and neurological symptoms, such as nervousness, depression, lethargy, nausea, loss of vibration and position sense, peripheral neuritis, etc. Vitamin B6 deficiency leads to anemia caused by the blockage of heme synthesis and folic acid metabolism. It is hypochromic microcytic anemia, but it is not iron deficiency, but insufficient utilization of iron, and excess iron is deposited in the form of ferritin in the liver, spleen, Bone marrow, liver and spleen may appear clinically. In addition, infants and young children lack of vitamin B6 can still experience growth retardation, weight loss, weight loss and other growth and development abnormalities.

The diagnosis of vitamin B6 deficiency in a narrow sense: it can be established mainly based on the medical history, symptoms, signs and necessary experimental examinations. After oral administration of 100 mg/kg of tryptophan, the excretion of xanthuric acid in urine can be measured, which can measure the nutritional status of vitamin B6 in the body.

The most effective way to treat vitamin B6 deficiency is to add a lot of vitamin B6. Patients taking a large amount of isoniazid or penicillamine should also take an appropriate amount of vitamin B6 to prevent peripheral neuritis caused by isoniazid and optic neuritis caused by penicillamine. TB patients with a history of seizures should be routinely given vitamin B6 when they must take isoniazid to prevent seizures.

Reference

  1. Vitamin B6 – WikiPedia
  2. (5-Hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate – PubChem
  3. Those Assisting Effects of Vitamin B6 – ChemicalBook

Vitamin B6 Supplier and Manufacturer

As a vitamin b6 supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best vitamin b6 raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for vitamin b6 and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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