Vitamin B6 CAS 8059-24-3 Pyridoxine

Azithromycin is a commonly used antibiotic for a variety of respiratory infections, but is often limited by its associated severe gastrointestinal side effects.

But azithromycin in combination with vitamin B6 can reduce its side effects.

Reason for combination

Azithromycin is a motilin receptor agonist that stimulates the gastric antrum and small intestine to produce similar physiological contractions, disturbs gastrointestinal motility, causes nausea, vomiting, and abdominal discomfort. By stimulating the release of acetylcholine in the gastrointestinal plexus, it increases gastrointestinal motility, causing abdominal pain, diarrhea, and loose stools.

Vitamin B6 is converted into pyridoxal phosphate in red blood cells, which can catalyze glutamate as a coenzyme. It can act on the vomiting center, thereby clearing or reducing gastrointestinal reactions.

At the same time, vitamin B6 is also involved in the conversion of tryptophan into niacin or serotonin, which can treat nausea, vomiting, and reduce intestinal allergy. And inhibit the release of acetylcholine, inhibit gastrointestinal motility, relieve gastrointestinal smooth muscle spasm.

Clinically, vitamin B6 combined with azithromycin is often used to treat children with mycoplasma pneumonia, and vitamin B6 can reduce the gastrointestinal reactions in children.

Primary dysmenorrhea refers to lower abdominal pain, bloating and other discomforts that occur during menstruation when there is no organic disease in the reproductive organs.

Vitamin B6 can be combined with desogestrel, ethinyl estradiol or progesterone in the treatment of primary dysmenorrhea.

Reason for combination

Vitamin B6 can increase the concentration of magnesium ions in uterine muscle cells, reduce the stimulation of muscle cells to external active substances, and make uterine muscles relax.

In addition, vitamin B6, as a coenzyme, participates in the synthesis of aminobutyric acid, which is a central nervous system inhibitory transmitter, and an increased content can cause muscle relaxation and reduce uterine smooth muscle tension.

Treating PMS
Premenstrual syndrome refers to the recurrent and periodic physical and mental symptoms that occur before menstruation, usually 7 to 14 days before menstruation. It also includes behavioral discomfort, such as insomnia, nervousness, restlessness, irritability, depression, breast tenderness, headache, loss of libido, etc., which seriously affects the life and work of the majority of women.

Clinically, fluoxetine can be used in combination with vitamin B6 to treat premenstrual syndrome.

Vitamin B6 can play a role in reducing the symptoms of premenstrual syndrome by promoting the body’s metabolism, regulating the autonomic nervous system, and inhibiting the synthesis of prolactin.

Hyperemesis gravidarum refers to frequent nausea and vomiting in early pregnancy and inability to eat, which can cause acidosis, water and electrolyte disorders, damage to liver and kidney function, affect the normal development of the fetus, and even cause pregnancy termination and threaten the life of pregnant women.

Clinically, procaine combined with vitamin B6 is used to treat hyperemesis gravidarum.

Reason for combination

Procaine may regulate gastrointestinal motility, relieve nausea and vomiting, and inhibit uterine contractions by inhibiting serotonin, regulating autonomic function, and blocking pathological impulses.

Vitamin B6 generates physiologically active pyridoxal phosphate and pyridoxine phosphate through enzymatic action in the body. It is the coenzyme of some amino acid transferases in the body and participates in many metabolic processes in the body.

It not only increases the production of the inhibitory neurotransmitter 7-aminobutyric acid in the brain, but also participates in the conversion of linoleic acid to arachidonic acid, which can increase the formation of PGl2. 7-aminobutyric acid is an important inhibitory transmitter in the central nervous system. PGl2 has a certain effect on promoting gastrointestinal smooth muscle peristalsis and regulating metabolism.

However, it is necessary to control the intensity of stimulation when using it. Excessive stimulation may cause uterine contractions and miscarriage, so caution should be used in clinical use.

Hand, foot and mouth disease in children is caused by viral infection. The main pathological changes are oral herpes, ulcers, inability to eat, severe pain, and herpes on the hands, soles, buttocks, and knees.

Based on the above characteristics, in addition to anti-inflammatory and antiviral treatment, vitamin C and vitamin B6 injections can also be used intravenously to assist in the treatment of children with hand, foot and mouth disease.

Vitamin C participates in oxidation and reduction reactions in the body, is necessary for the synthesis of collagen and interstitial cells, reduces the permeability of capillaries, accelerates blood coagulation, reduces blood lipids, increases resistance to infection, and promotes granulation tissue growth and wound healing , involved in detoxification.

And vitamin B6 has a sedative effect on the central nervous system, reduces gastrointestinal reactions, and can also promote the healing of oral ulcers.

The synergistic effect of the two speeds up the healing of oral ulcers, and also promotes the healing of rashes on hands, feet, buttocks and knees.