Protocatechuic acid CAS 99-50-3


Basic Info

Product Name:

Protocatechuic acid

Other Names:

Protocatechuic aci



Place of Origin:

Shandong, China

Brand Name:

Zhishang Chemical




White powder




Cool Dry Place



Chemical Properties:

Protocatechuic acid is white to slightly brown needle-like crystals with a melting point of about 200°C (decomposition). It is soluble in hot water, ethanol and ether, slightly soluble in cold water, and insoluble in benzene. Decomposes in boiling water and emits carbon dioxide. The aqueous solution is green when it meets ferric chloride, and dark red when it meets sodium bicarbonate


  1. Protocatechuic acid can be used as dyes and pharmaceutical intermediates.
  2. Protocatechuic acid as dyes, pharmaceutical intermediates, analytical reagents (testing iron).
  3. Protocatechuic acid can be used to study the effects of 4-coumaric acid and 3,4-dihydroxybenzoic acid on basic oxidative DNA damage of rat colonic mucosa in vivo.Protocatechuic acidcan be used for the derivatization of chitosan resin.
  4. The rat cardiopulmonary perfusion hypoxia test method was used to directly measure the hypoxia tolerance of the rat myocardium. Protocatechuic acid was observed that after intravenous injection of 10 mg of protocatechuic acid, the myocardium can be used to withstand hypoxia. Amine coumarin is slightly inferior. 3min after administration, the cardiac output increased by 10%. Protocatechuic acid can be seen that protocatechuic acid can significantly prolong the time of myocardial resistance to hypoxia whenProtocatechuic acidslightly improves cardiac function, and at the same time, Protocatechuic acidcan reduce the blood pressure drop caused by hypoxia. Slow down the heart rate, which is beneficial to prolong the time of myocardial resistance to hypoxia. Atmospheric hypoxia tolerance experiments proved that protocatechuic acid can prolong the survival time of mice (maintain more than one and a half hours), which is similar to the effect of the same dose of persentine.
  5. After intravenous injection of protocatechuic acid, the coronary resistance gradually decreased, lasting about 30 minutes, and returning to the original level after about 1 hour. During this period, the systemic blood pressure increased slightly. Protocatechuic acid can dilate the blood vessels in the hind limbs of cats but has no obvious changes in dogs. The mixture of protocatechuic acid and protocatechualdehyde shows a slow and mild boosting effect, which can dilate the blood vessels in the lower limbs of the animal, but the splenic blood vessel reaction is mild, which can indicate the relationship between the boosting effect and the changes in peripheral and certain internal organs. Not big, soProtocatechuic acidhas nothing to do with α-receptor excitement.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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