Praziquantel CAS 55268-74-1
Factory Supply Praziquantel CAS 55268-74-1 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Praziquantel Supplier & Manufacturer
Praziquantel: The Complete Guide
Praziquantel for Sale
|Other Name:||Praziquantel powder; Praziquantel raw material|
|Type:||Feed additives; Pharmaceutical raw materials; Raw materials of pesticides; Pharmaceuticals, dyes, pesticide intermediates|
What is Praziquantel?
Trematodes is an overlooked exotic condition that seriously jeopardizes human health as well as affects social and economic advancement. Today, schistosomiasis prevails in 76 nations and also regions in the world, with virtually 200 million infected individuals and also virtually 800 million citizens encountering the risk of infection j. Schistosomiasis is primarily widespread in my country. By the end of 2010, there were 453 schistosomiasis-endemic regions nationwide, with 325,800 schistosomiasis patients.
Praziquantel is a broad-spectrum anthelmintic synthetic drug uncovered abroad in the 1970s. After it was reported to be efficient against schistosomiasis in 1977, it was trial-produced in China in the exact same year and confirmed to have a considerable result on schistosomiasis. This product is an anemic crystalline powder, Odorless as well as slightly bitter, very steady under typical conditions. Soluble in chloroform, dimethyl sulfoxide and other natural solvents, slightly soluble in ethanol, barely soluble in water. The histochemical observation results of in vivo and also in vitro examinations showed that after the activity of the medication, the glycogen of schistosomiasis reduced dramatically, ribonucleic acid and alkaline phosphatase also reduced, while the activity of alkaline healthy protein reaction or acid phosphatase enhanced. It is likewise believed that after the medicine acts upon the worm body, the skin of the worm will promptly denature, as well as the surface antigen of the worm will be exposed, to make sure that it can not escape the immune attack of the host. The medication can additionally advertise fast liver movement of worms. Animal experiments have actually shown that when the blood concentration gets to 0.3 μg/ ml, it has insecticidal result and also high restorative index. The medication is conveniently soaked up by the intestine, and also the blood concentration gets to the peak in about 2 hrs. The circulation in the body has the highest possible focus in the liver, and also most of the metabolites after the medication is metabolized are excreted by the kidneys within 24 hours without buildup. This product likewise has a considerable result on the larvae of Mansoni as well as Schistosoma japonicum that initially go into the skin. At reduced concentrations, it can kill miracidia and also cercariae, as well as can prevent the advancement of schistosome larvae of spirochetes right into cercariae. Praziquantel has a good restorative effect on schistosomiasis, and additionally has satisfying medicinal results on clonorchiasis, paragonimiasis and also tapeworm.
For a variety of intestinal parasitic diseases. This product has the effect of repelling and killing various parasites such as Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium, Clonorchis sinensis, paragonimiasis, fasciola japonicum, tapeworm and cysticercosis.
Praziquantel is used to prevent schistosome infection. External application on the skin can be used to prevent schistosomiasis infection.
Praziquantel has broad-spectrum anti-schistosome and anti-tapeworm effects. It has extremely high activity against adults of various tapeworms, and also has good activity against larvae; it has a good killing effect on schistosomes. It has repellent effect on the Monitz tapeworm, the ball spot worm and the yolkless gland tapeworm, and it is effective against the pancreas fluke and the lanceolata; it is also effective against the thin-necked cysticercosis and Schistosoma japonicum of cattle and sheep. Good effect; it has good relative effect on cysticercosis of pigs; it has high efficiency on various tapeworms of dogs, cats and poultry.
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Application of Praziquantel
Studies have shown that praziquantel can interfere with the Ca2+ internal environment of schistosomes. Praziquantel may change the permeability of worms to Ca2+, promote inflow and contracture of worms, or change the distribution of Ca2+ in cortical cytoplasm and muscle and cause cortical damage; It is manifested as the activity of the worm body, followed by the contraction of the worm body. These reactions depend on the existence of Ca2+ and are restricted by M. The schistosomiasis cultured in vitro can cause cortical damage after being treated with praziquantel for 5 minutes, white blood cells and macrophages It is easy to enter the insect body through the damaged part and further decompose the insect body.
The internal environment of Ca2+ in Schistosoma cells can be regulated by some cellular components, such as: voltage-gated calcium channels (Voltagegated calcium channels, VGCCs), ligand-gated calcium channels, second messenger-gated calcium channels, etc., these channels may become praziquantel Targets for regulation of Ca2+ homeostasis.
Generally mild and short-lived, does not affect the treatment. Common ones are:
- Neuromuscular reactions: such as headache, dizziness, fatigue, etc.
- Digestive system reactions: abdominal pain, nausea, etc., occasionally blood in the stool, liver pain.
- Cardiovascular system reactions: Chest tightness, palpitations, premature contractions, etc. are more common, occasionally supraventricular tachycardia, atrial fibrillation, etc., ECG can show transient changes, T wave changes and premature contractions are more common.
- Allergic reactions: skin rash, fever, etc. Severe reactions such as fainting, flaccid paralysis, angina pectoris, severe arrhythmia, jaundice, etc. are only seen in individual cases, and most of them disappear quickly.
- Praziquantel – WikiPedia
- Li Xin; Xia Chaoming. Research progress on the mechanism of action of praziquantel against schistosomiasis. 2008. PhD Thesis.
Praziquantel Supplier and Manufacturer
As a praziquantel supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best praziquantel raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for praziquantel and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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