Potassium Tert-Butoxide CAS 865-47-4
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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Potassium Tert-Butoxide: The Complete Guide
Index of Potassium Tert-Butoxide Contents
Potassium Tert-Butoxide for Sale
Basic Info of Potassium Tert-Butoxide
Potassium tertiary butoxide; tert butoxide; potassium tertiary butoxide cas no 865-47-4; tert butylate de potassium; kalium tert butoxide;
Pharmaceutical raw materials; Pharmaceutical, pesticide, dye intermediates; synthetic material intermediates
What is Potassium Tert-Butoxide?
Potassium tert-butoxide is a compound with the chemical formula k + (CH 3) 3 co -. This colorless solid is a strong base (pKa of conjugated acid is about 17) and can be used in organic synthesis. It exists in the form of tetrameric cubane clusters. It is often written as potassium TERT butanol in the chemical literature. The compound is usually described as a salt, which usually behaves as such, but does not ionize in solution.
Potassium tert-butoxide is an important organic base, more basic than potassium hydroxide. As a result of the inductive result of (CH3)3CO-three methyl teams, it is more basic and energetic than various other potassium alkoxides, so it is an excellent driver.
Furthermore, as a solid base, potassium tert-butoxide is widely utilized in chemical, pharmaceutical, chemical and also various other organic synthesis, such as transesterification, condensation, solid rearrangement, polymerization, ring opening and also the production of heavy metal orthoesters. It can be used to catalyze Michael addition reaction, Pinacol rearrangement reaction and Ramberg-Backlund rearrangement reaction; potassium tert-butoxide is used as a condensing agent and can be used to catalyze Darzens condensation reaction, Stobbe condensation reaction; it is also a traditional generation of dihalogenated carbene The most efficient base for the alkoxide-haloform reaction. Therefore, potassium tert-butoxide is more and more favored by chemical, pharmaceutical, pesticide and other industries. Potassium tert-butoxide is so widely used, so there is a large demand for high-purity potassium tert-butoxide at home and abroad. But because its production cost is higher than other alkali metal alkoxides, the production technology needs to be perfected, so the in-depth study of potassium tert-butoxide is particularly important.
Potassium Tert-Butoxide Uses
- As a strong base, potassium tert-butoxide is widely used in condensation, rearrangement and ring-opening reactions in organic synthesis such as chemical industry, medicine and pesticide.
- Tert butanol itself can be made use of as a solid non nucleophilic base in organic chemistry. Its space volume hinders the team from taking part in nucleophilic addition, such as Williamson ether synthesis or S N 2 response. Substrates deprotonated by potassium TERT butanol include terminal acetylene as well as active methylene substances. It can be used for dehydrohalogenation response.
- Potassium TERT butanol catalyzes the reaction of hydrosilane and heterocyclic compounds to produce silyl derivatives and release H 2 at the same time.
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Related Reactions of Potassium Tert-Butoxide
t-BuOK is a moderately strong base commonly used in organic synthesis. Its basicity is stronger than that of alkali metal hydroxides and primary and secondary alkoxides of alkali metals; weaker than that of amino alkali metals and their alkyl derivatives. t-BuOK is widely used because it is inexpensive and readily available, and its basicity varies with the chosen reaction solvent.
The t-BuOH solution of t-BuOK can efficiently carry out the alkylation reaction at the α-position of the carbonyl group. t-BuOK in t-BuOH or benzene is also commonly used for the alkylation of α,β-disubstituted aldehydes. The α,β-unsaturated ketone is treated with an excess of t-BuOK/t-BuOH and an alkylating reagent to give α,β-dialkylated products. Catalytic amounts of t-BuOK can catalyze the addition of ketones or imines to styrene in DMSO to yield alkylated products in high yields (Equation 1).
Compared with intermolecular reactions, t-BuOK can catalyze intramolecular alkylation in different solvents. Intramolecular alkylation of α,β-unsaturated ketones can occur at the α-, α2-, or γ-positions, depending on the nature of the base, leaving group, and other structural features (Equation 2).
Precautions of Potassium Tert-Butoxide
Potassium tert-butoxide is available in both liquid and solid types. Usually the liquid industrial product is the tert-butanol solution of potassium tert-butoxide, the color of the product is light yellow or milky white, slightly turbid, and the content of potassium tert-butoxide is 10%~12%; the solid product is generally white or off-white powder The content of potassium tert-butoxide is 95%~97%.
Potassium tert-butoxide is an organic alkaline corrosive product, which is highly hygroscopic. It should be sealed and stored. Generally, it should be stored in a cool, dry and ventilated warehouse. When placed, it should be kept away from heat sources, isolate fires, and prevent sunlight exposure. Potassium tert-butoxide is highly corrosive to the skin. During loading and unloading, operators should wear protective masks to prevent corrosion and burns from potassium tert-butoxide.