Phenylethyl Resorcinol CAS 85-27-8
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Phenylethyl Resorcinol Supplement
Phenylethyl Resorcinol: The Complete Guide
Phenylethyl Resorcinol for Sale
Basic Info of Phenylethyl Resorcinol
4-(alpha-Methylbenzyl)resorcinol; Nanoactive Phenylethyl Resorcinol
Food additives; Pharmaceutical raw materials; Organic raw materials; Cosmetic raw materials; Pharmaceutical intermediates; Synthetic material intermediates
What is Phenylethyl Resorcinol?
Phenylethyl Resorcinol (Phenylethyl Resorcinol), molecular formula C14H14O2, full chemical name 4-(1-phenethyl)-1,3-benzenediol, is a white crystalline strong with low smell. Soluble in ethanol, propylene glycol, butanediol, pentanediol, as well as the solubility in water is 265mg/L at 25 ° C. Phenethylresorcinol is an efficient bleaching component developed by Symrise. It has a solid antioxidant effect and highly hinders the task of tyrosinase, thus lowering the manufacturing of melanin. Skin tests revealed that 0.5% 377 was extra efficient than 1% kojic acid in the lack of light direct exposure. In 2012, the China Fda (SFDA) has actually accepted phenethyl resorcinol as a cosmetic raw material for usage in cosmetics.
Given that phenethyl resorcinol is a by-product of fat-soluble resorcinol, it is insoluble in water as well as unstable when subjected to light. Under the problem of light, phenethyl resorcinol can become pink shade such as quinones. compound. These issues result in considerably minimized bioavailability of phenethylresorcinol. For that reason, it is required to take certain procedures to enhance its photostability, therefore improving its bioavailability as well as the legitimacy period of cosmetics.
The chemical name of phenylethyl resorcinol is 4-(1-phenylethyl)-1,3-benzenediol, which is an useful active ingredient with exceptional whitening result. It mainly achieves lightening by inhibiting the task of tyrosinase. Purpose. Existing studies have actually revealed that phenethyl resorcinol can properly whiten the skin when the dosage is greater than 0.5%, and can additionally effectively stand up to oxidation as well as crease at the same time. Nevertheless, high concentrations of phenylethyl resorcinol can trigger skin allergic reactions when made use of in cosmetics. The limit of use in cosmetics is 0.5%. The trouble of very easy allergic reaction makes it difficult to utilize phenylethyl resorcinol in large doses. A better bleaching effect can not be achieved.
Phenylethyl Resorcinol Uses
- The chemical name of phenylethyl resorcinol is 4-(1-phenylethyl)-1,3-benzenediol, which is a practical component with superb bleaching impact. It mostly attains bleaching by hindering the task of tyrosinase. Objective. Existing researches have actually shown that phenethyl resorcinol can successfully bleach the skin when the dosage is greater than 0.5%, and also can additionally properly resist oxidation and also wrinkle at the same time. Nonetheless, high focus of phenylethyl resorcinol can trigger skin allergies when utilized in cosmetics. The limit of use in cosmetics is 0.5%. The trouble of very easy allergy makes it hard to make use of phenylethyl resorcinol in large dosages. A much better bleaching impact can not be attained.
- 4-(1-Phenoxyl)-1,3-benzenediol is a new active ingredient of skin lightening agent with high efficiency.
- Phenylethyl resorcinol has a good effect of inhibiting melanin. At present, there are two main methods for inhibiting melanin production, namely inhibiting the activity of tyrosinase and controlling the oxidation of dopa. Phenylethyl resorcinol is a One of the reported tyrosinase inhibitors with the highest activity, the key factor is that it has a bisphenol structure, which can play a competitive inhibitory role on tyrosinase. In recent years, more and more big brand cosmetics have gradually Replaced this ingredient.
- Phenylethyl resorcinol is often used as a brightening agent in cosmetics, but because the product has a certain irritant effect on the skin, the dosage of the product is limited, and the manufacturer recommends that the dosage is usually 0.1%-1.0% , the domestic limit of 377 concentration, the highest is 0.5%.
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Application of Phenylethyl Resorcinol
- Mix the water 75%wt~100%wt, collagen extract 1%wt~5.0%wt, hydrolyzed beta glucan 1%wt~3.0%wt, glycerol 1%wt~2.0%wt, butylene glycol 1%wt~2.0%wt, betaine 0.1%wt~1.0%wt, allantoin 0.1%wt~0.2%wt, cylindrine 0.1%wt~0.2%wt were poured into the reaction kettle and heated to a temperature of 85 Celsius, that is A phase.
- The described phenethyl resorcinol 1%wt～4.0%wt, dioctyl carbonate 1%wt～4.0%wt, squalane 1.0%wt～3.0%wt, stearyl alcohol 1%wt～ 3.0%wt, steareth-21%wt~2.0%wt, steareth-211%wt~2.0%wt, tocopherol 0.1%wt~0.5%wt, bisabolol 0.1%wt~ 0.2%wt is poured into the reaction kettle and heated to a temperature of 85 degrees Celsius, which is the B phase.
- Pour the imidazolidinyl urea 0.1%wt～0.2%wt, essence 0.1%wt into the reaction kettle, stir evenly, and be phase C.
- Mix phase A and phase B evenly, homogenize for 10 minutes, then cool, add phase C at a temperature of about 30 degrees Celsius, stir evenly, and discharge to obtain freckle cream.
Preparation of Phenylethyl Resorcinol
0.2 mol of 2,4-diacetoxystyrene was put into a three-necked flask with stirring, 4 mol of benzene was placed in, and also 0.001 mol of p-toluenesulfonic acid was placed in, the temperature level was increased to 80 ° C. as well as refluxed, as well as the temperature was kept for 5 hrs. After that the temperature level was reduced to 50 ° C., 4 mol of methanol was added, the temperature level was raised to 64 ° C. as well as refluxed, and also the temperature was kept for 1 hr. Then, climatic purification was performed to boil down off the solvent. The recurring material in the flask was recrystallized to acquire 32 g of phenethyl resorcinol, which was detected by fluid chromatography, as well as the material was 99.5% and the return was 80%.
- Phenylethyl resorcinol – PubChem
- Zhao Shizhi, Fang Qingqiu, Ye Jun, Yang Shan, & Wang Lei. (2014). Preparation and stability analysis of phenethylresorcinol nanostructured lipid carriers. Food and Drugs, 16(6), 384-388.