o-Phenanthroline CAS 66-71-7
Factory Supply o-Phenanthroline CAS 66-71-7 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: o-Phenanthroline Suppiler
o-Phenanthroline: The Complete Guide
o-Phenanthroline for Sale
Basic Info of o-Phenanthroline
1,10-Phenanthroline anhydrous; 1,10-Phenanthroline; Ortho-phenanthroline
Pharmaceutical intermediates; Organic raw materials
What is o-Phenanthroline?
O-phenanthroline is an organic compound with molecular formula C12H8N2. The solid is white crystal and dissolves in water to form a light yellow to yellow solution. When recrystallized with water, it contains a crystal water molecule. The o-phenanthroline hydrate is a white crystal. When recrystallized with benzene, there is no crystal water, and the melting point is 98-100 ℃ (117 ℃). The boiling point is above 360 ℃. Soluble in ethanol, benzene and acetone, insoluble in petroleum ether. It forms complexes with iron, copper, cobalt, nickel and 2,2-BIPYRIDINE, forms red complexes with Fe2 +, and oxidizes with potassium permanganate to obtain 2,2-bipyridine-3,3 ‘- dicarboxylic acid.
O-phenanthroline is a common redox indicator. It is a bidentate heterocyclic compound ligand, similar to 2,2-BIPYRIDINE. It is a common auxiliary ligand in the construction of crystal materials. It has a strong chelating property and can form very stable complexes with most metal ions. It can be used as a quantitative colorimetric reagent for copper and iron, and also as an indicator for cerium sulfate titration of iron salts; It can also be used as a dye for animal fibers.
O-phenanthroline can form facilities with different transition metals. Given that the complicateds created are chelate complexes, they are fairly steady. The complicateds and also their by-products formed with copper can be used as non-oxidative nucleic acid cleaving enzymes because they have particular cleavage activity on DNA, and also further have specific anticancer tasks.
O-phenanthroline is a typical ligand for spectroscopic decision of steels and also spectroscopic evaluation of CO2 reduction. It is used for the cross-linking response of organic boronic acid catalyzed by Cu(II), etc. It can also be used as a redox sign as well as a reagent for the decision of ferrotitanium.
It forms facilities with iron, copper, cobalt, nickel as well as 2,2′-bipyridine, forms red facilities with Fe2+, as well as is oxidized with potassium permanganate to acquire 2,2′-dipyridyl-3,3′-dicarboxylate acid. It can be used as a measurable colorimetric reagent for copper as well as iron, and as an indication for titrating iron salts with cerium sulfate; it can likewise be used as a dye for pet fibers. The o-phenanthroline-Fe(II) indicator can be prepared by liquifying 1.485 g of o-phenanthroline monohydrate and 0.695 g of FeSO4-7H2O in 100 mL of water. Indicator for ceric sulfate titration of iron salts. A related ligand is red phenanthroline (BPT), 4,7-diphenyl-1,10-phenanthroline. O-phenanthroline can likewise be used for the analysis of the material of alkyl lithium substances. The details steps are to make the example react with a small amount (about 1 mg) of o-phenanthroline to provide a dark shade, and after that titrate with alcohol till the colorless titration end point is reached.
In the solution of pH=2 ~ 9, o-phenanthroline responds with divalent ferrous ion (Fe2+), the selectivity of this reaction is very high, and also the resulting orange-red complex is extremely secure, lgK stable = 21.3 (20 ° C), its option has an optimum absorption top at 510nm (visible light), as well as this shade reaction can be made use of to establish trace iron by visible light spectrophotometry.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
- Email: email@example.com
- Phone: +86 176 5311 3209
- WhatsApp: +86 176 5311 3209
- WeChat: Zhishang17653113209
- Skype: +86 176 5311 3209
If you want to buy o-phenanthroline, pls contact us to get a free quote.
Application of o-Phenanthroline
Synthesis of 2-hydroxy-1,10-o-phenanthroline
Starting with l,10-phenanthroline, and then adding structural modifications on this basis, it is an important method to synthesize l,10-phenanthroline derivatives. The derivatives obtained in this way are mainly concentrated in 5, The 6-position, 3,8-position, 2,9-position, and the 5,6-position produced the highest number of derivatives. Derivatives of phenanthroline, as good metal ligands, are widely used in antibacterial and antitumor, catalytic reactions, supramolecular chemistry, DNA probes, molecular switches, etc. 2-Hydroxy-1,10-o-phenanthroline is an important 2-position derivative in 1,10-o-phenanthroline derivatives. The main synthesis method is through 2-halogenated-1,10-o-phenanthroline. The hydrolysis reaction is obtained. Due to the lack of access routes, there are relatively few studies on the properties and applications of 2-hydroxy-1,10-phenanthroline reported in the literature. CN201710460068.1 provides a kind of synthetic method of 2-hydroxyl-1,10-o-phenanthroline, and increases the source route of target product. For this reason, the present invention adopts the following route to synthesize 2-hydroxy-1,10-o-phenanthroline:
The reaction method takes 1,10-o-phenanthroline (2) as a starting material, reacts with benzyl halide to obtain an intermediate quaternary ammonium salt (3), and then oxidizes it with potassium ferricyanide to obtain 1-benzyl-1,10 -o-phenanthroline-2-one (4), then debenzylated under palladium-carbon catalysis to obtain 2-hydroxy-1,10-o-phenanthroline (1).
The preparation scheme of 2-hydroxy-1,10-o-phenanthroline is as follows: 1,10-o-phenanthroline (2) and benzyl halide are heated to obtain 1-benzyl-1,10-o-phenanthroline halide salt (3 ), 1-benzyl-1,10-o-phenanthroline halide salt (3) was oxidized by potassium ferricyanide in cold aqueous solution to obtain 1-benzyl-1,10-o-phenanthroline-2-one (4) ), and finally low-pressure hydrogenation in the presence of palladium-carbon catalyst to obtain 2-hydroxy-1,10-o-phenanthroline (1). The benzyl halide used in this scheme can be selected from benzyl chloride or benzyl bromide, and can also be a derivative of benzyl chloride or benzyl bromide; it is better to control the temperature at -5 to 5°C when potassium ferricyanide is oxidized; The hydrogen pressure in the case of the benzyl group may be normal pressure or a hydrogen pressure not higher than 1 MPa.
- 1,10-Phenanthroline – PubChem
- CN201410517030.X Organo-silica hybrid capillary monolithic column modified by o-phenanthroline
- Evaluation of uncertainty in the determination of iron content in industrial sodium hydroxide by 1,10-phenanthroline Spectrophotometry.