Lidocaine HCl CAS 6108-05-0 Linocaine Hydrochloride
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Lidocaine HCl Suppiler&Manufacturer
Lidocaine HCl: The Complete Guide
Lidocaine HCl for Sale
Basic Info of Lidocaine HCl
What is Lidocaine HCl?
The chemical name of lidocaine hydrochloride is N-(2,6-xylyl)-2-(diethylamino)acetamide hydrochloride-hydrate, which is a common amide local anesthetic. The patch can be used as a topical anesthetic, has analgesic effect, can be absorbed through the skin or mucous membranes, and is clinically used for local infiltration anesthesia before superficial surgery on the skin or mucous membranes; it can also relieve post-herpetic neuralgia, like other local anesthetics , Topical application has a certain antipruritic effect, and also has an antiarrhythmic effect.
Lidocaine hydrochloride is an intermediate-acting amide local anesthetic. For local anesthetics and also antiarrhythmic drugs. Generally made use of for:
- Infiltration anesthetic, epidural anesthesia, topical anesthesia (including mucosal anesthetic during thoracoscopy or stomach surgical treatment) and nerve transmission block.
- Treat ventricular early beats as well as ventricular tachycardia after acute myocardial infarction (AMI), and ventricular arrhythmia brought on by digitalis poisoning, heart surgical treatment, and also cardiac catheterization, however it is normally ineffective for supraventricular arrhythmias.
Lidocaine HCl Uses
Linocaine hydrochloride is a fast voltage gated sodium channel blocker.
Lidocaine hydrochloride is an amide type local anesthetic. After blood absorption or intravenous administration, the drug has evident biphasic effects of excitation and restraint on the main nervous system, and also there can be no forerunner excitation. When the blood focus is low, analgesia, sleepiness, and the discomfort limit are raised; With the boost of the dose, the effect or toxicity increases, and also the sub poisonous blood focus has an anticonvulsant result.
Lidocaine hydrochloride has the characteristics of strong penetrability, solid diffusion and also fast beginning. Its anesthetic efficiency is two times that of procaine, while its toxicity is 1. Anesthetic can occur 5 mins after management, as well as the anesthetic impact lasts for 1 to 1.5 hours, 50% longer than that of procaine. After absorption, it can inhibit the main nerve system, prevent the ventricular automaticity, shorten the refractory period, and can be made use of to regulate ventricular tachycardia as well as treat ventricular early beats, ventricular tachycardia, ventricular fibrillation and also various other arrhythmic symptoms. It is effective for heart disease or arrhythmia triggered by heart glycosides, but not for supraventricular tachycardia. This product has quickly action, brief period and also is inefficient after oral management. It is commonly made use of as an intravenous shot.
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Preparation of Lidocaine HCl
Preparation of intermediate 2,6-dimethylaniline
24.43 g (0.2 mol) of 2,6-xylenol, 63.1 g (0.6 mol) of ammonia water, 1.06 g of 5% Pd/C, and 2.52 g (0.02 g of 2,6-dimethylcyclohexanone) were successively added to the reaction vessel. mol), reacted at 185 °C for 6 h, cooled to room temperature, filtered, recovered Pd/C and applied; the filtrate was distilled under reduced pressure, recovered 2,6-dimethylcyclohexanone and applied next time, the residue was washed with water once, and left to stand for stratification. , the oil layer is the intermediate 2,6-dimethylaniline 23.35g, the HPLC purity is 98.32%, and the yield is 94.73%.
Preparation of lidocaine hydrochloride
To the there-necked flask with the distillation device, add 15.12g (0.28mol) of sodium methoxide, 24.24g (0.2mol) of the intermediate 2,6-dimethylaniline and 31.9g (0.22g) of N,N-diethylaminoacetate methyl ester successively. mol), heated to 95°C, and the methanol generated by the reaction was distilled off while reacting, until no methanol was evaporated, continued the reaction for 30 min, cooled to room temperature, added dichloroethane to dissolve, washed twice with water, and allowed to stand for stratification. The organic layer is the dichloroethane solution of lidocaine base.
In the dichloroethane solution of above-mentioned lidocaine base, add hydrochloric acid 2.56g, then adjust the pH to 3.5 with hydrogen chloride, add activated carbon to reflux for 20min, filter, concentrate the filtrate, crystallize by cooling, dry to obtain lidocaine hydrochloride 48.28g, HPLC purity was 99.52%, the yield was 88.72%, and the total yield was 84.04%.
- Cimetidine as well as β-blockers can prevent the metabolic process of lidocaine in the liver and enhance the blood focus, which can cause adverse reactions of the heart as well as nervous system. The dose of lidocaine hydrochloride need to be adjusted.
- Barbiturates can advertise the metabolism of lidocaine hydrochloride, and also the combination of the two medications can cause bradycardia and sinus apprehension.
- Combination with procainamide can create transient ecstasy and also hallucinations, but does not influence the plasma concentration of this item.
- Isoproterenol increases hepatic blood circulation, which can increase the total clearance price of this product; norepinephrine reduces hepatic blood flow, which can reduce the total clearance price of lidocaine hydrochloride.
- Conflict with the adhering to drugs: phenobarbital, thiopental sodium, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine.
Lidocaine HCl Suppliers and Manufacturers
As a lidocaine hcl supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best lidocaine hcl raw materials to customers all over the world.
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