Itaconic acid CAS 97-65-4
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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Itaconic acid: The Complete Guide
Index of Itaconic acid Contents
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Basic Info of Itaconic acid
Basic Info
Chemical Name: | Itaconic acid |
Other Name: | Methylenebutenedioic acid;Itaconic acid,CP,99%;Itaconic acid;Methylenesuccinic acid;2-Propylene-1,2-dicarboxylic acid;Methylenesuccinic acid;ITACONIC ACID Itaconic acid; itaconic acid manufacturers; itaconate |
CAS: | 97-65-4 |
EINECS: | 202-599-6 |
Type: | Organic Raw Materials |
Molecular Formula: | C5H6O4 |
Molecular Weight: | 130.1 |
Chemical Properties
Melting point | 165-168 °C (lit.) |
Boiling point | 268°C |
Density | 1.573 g/mL at 25 °C (lit.) |
Vapor pressure | 0.0000115 Pa (20 °C) |
Refractive index | 1.4980 (estimate) |
Fp | 268°C |
Storage temp. | Store below +30°C. |
Solubility | 77.49g/l |
Pka | 3.85(at 25℃) |
Form | Crystalline Powder or Crystals |
Color | White to light beige |
Specific Gravity | 1.573 |
PH | 2 (10g/l, H2O, 20℃) |
Water Solubility | Soluble in water, acetone, methanol, hexane and ethanol. Slightly soluble in benzene, chloroform, carbon disulfide and petroleum ether. |
Sensitive | Hygroscopic |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Itaconic acid MSDS; Itaconic acid COA |
What is Itaconic acid?
Itaconic acid is a five-carbon dicarboxylic acid, also known as methylene succinic acid and methylene succinic acid. It is one of three products when citric acid is distilled, the other two being citraconic acid and mesaconic acid. The word Itaconic is a translocation of the word aconitic.
Itaconic acid (itaconate) is one of the best examples of metabolic reprogramming during immunity. It is synthesized in macrophages by cis-aconitate in the tricarboxylic acid cycle (TCA cycle), which are activated by a variety of factors, especially lipopolysaccharide (LPS), and other Toll Like receptor (TLR) ligands and cytokines, such as type I and type II interferons, these stimuli increase aconitate decarboxylase 1 (ACOD1; also known as CAD), originally called the immune response Gene 1 protein (IRG1), cis-aconitic acid is diverted from the TCA cycle, repurposed to produce itaconic acid). The current study shows that itaconic acid is an important immune metabolite with profound effects on immunity, host defense and tumorigenesis.
Itaconic acid Uses
- As a copolymer of polyacrylonitrile fiber, it can also be used to prepare plasticizer, lubricating oil additive and so on.
- Itaconic acid can be used as a chemical reagent, a monomer for synthetic fibers and synthetic resins, a binder, and the like.
- Polyvalent metal oxides can be used as dental adhesive, which has good extrusion performance, strong adhesion and good physiological adaptability.
- Itaconic acid has an inhibitory effect on isocitrate lyase, which is a key part of glyoxylate shunt, so itaconic acid can be used as an antibacterial agent.
- Itaconic acid inhibits fructose-6-phosphate 2-kinase and has a direct effect on central carbon metabolism. In rats, an itaconate diet resulted in decreased visceral fat accumulation due to inhibition of glycolytic flux.
- Itaconic acid can be an inhibitor of metabolic pathway.
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