Hydroxypropyl Methyl Cellulose Phtalate CAS 9050-31-1 HPMCP

Hydroxypropyl methyl cellulose phthalate (hydroxypropylmethylcellulose phthalate, or HPMCP) is the phthalate of hydroxypropylmethyl cellulose. In the pharmaceutical industry, hydroxypropyl methyl cellulose phthalate is made use of as a coating representative for tablets and also granules. It is an anemic and tasteless white powder. Hydroxypropyl methyl cellulose phthalate is prepared by esterification of hydroxypropyl methylcellulose and phthalic anhydride. The level of replacement of alkoxy and carboxybenzoyl teams figures out the residential properties of polymers, particularly the pH worth when they are dissolved in aqueous media.

Hydroxypropyl methyl cellulose phthalate was introduced as a cellulose derivative for enteric finishing in 1971. The enteric layer agent is utilized to safeguard the medication from degradation by gastric acid or prevent the medicine from causing negative effects in the stomach. It is extensively made use of as enteric coating representative in pharmaceutical sector. HPMCP has been consisted of in the United States National Formulary (US/ NF). HPMCP is also made use of in sustained release solutions, adhesives and also microcapsule matrices.

Despite the lack of particular researches, there are some problems regarding making use of phthalates in drugs, the overall exposure to phthalates, and also possible poisoning. Chronic and severe animal feeding studies on several different types revealed no evidence of teratogenicity or poisoning of HPMC. Hydroxypropyl methyl cellulose phthalate is typically taken into consideration as a non bothersome and non-toxic product. FDA knows using phthalates in enzymes. Phthalates are consisted of in the inactive component checklist of its FDA approved medications. It is well known that phthalates are eliminated from urine, however the collected data are uncertain