Hydroxylamine Hydrochloride CAS 5470-11-1
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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
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Hydroxylamine Hydrochloride: The Complete Guide
Hydroxylamine Hydrochloride for Sale
Basic Info of Hydroxylamine Hydrochloride
Hydroxylammonium chloride; Hydroxylamine HCL; NH2OH·HCl
Inorganic salts; Pharmaceutical, pesticide, dye intermediates; Organic intermediates; Pesticide intermediates; Organic raw materials
What is Hydroxylamine Hydrochloride?
Hydroxylamine hydrochloride is an inorganic compound with the chemical formula NH2OH·HCl, which is usually used as a reducing agent.
Hydroxylamine hydrochloride is colorless monoclinic crystal, easily soluble in water, soluble in ethanol, glycerol, and insoluble in ether. It has strong hygroscopicity and gradually decomposes after being wet. It also decomposes when heated to above 151°C.
Hydroxylamine chloride can reduce the blue cupro ammonia solution to produce a colorless cuprous ammonia solution:
4 [Cu(NH3)4]2+ + 2 NH2OH2+ + H+ → 4 [Cu(NH3)2]+ + N2O + H2O + 4 H+ + 8 NH3 + H2O
It reacts with zinc oxide or zinc carbonate to generate hydroxylamine complex Zn(ONH3)Cl2.
Sodium nitrite and sodium metabisulfite react in water, acidify with sulfuric acid, add a certain amount of acetone, and neutralize with liquid caustic soda. The acetone oxime is distilled out, and the acetone oxime is reacted with a certain proportion of hydrochloric acid to generate hydroxylamine hydrochloride and acetone. Hydrolysis of nitromethane and hydrochloric acid produces hydroxylamine hydrochloride.
Hydroxylamine Hydrochloride Uses
- Hydroxylamine hydrochloride is an important organic chemical intermediate, mainly used in the preparation of oximes in organic synthesis reactions, such as the intermediate of trimoxazole in the pharmaceutical industry, and the preparation of isatin intermediate in the synthetic dye industry.
- In medication, it is additionally made use of to create cotrimoxazole, danazol, ethinyl estradiol, norethisterone, methyl testosterone, hydroxyurea, chlordiazepoxide, etc. In the artificial rubber industry, it is utilized as a non-coloring short-term quit.
- Because hydroxylamine hydrochloride has a good decreasing impact, it is frequently made use of as a lowering representative in industry, such as in the oil industry, it can be used as an antioxidant as well as antioxidant for fatty acids and soaps.
- Not natural evaluation of decreasing agents, complexing representatives, electroanalytical depolarizers, anti-oxidants for fats as well as soaps, analysis of formaldehyde, camphor and also glucose, and so on, organic analysis of aldehydes and also ketones, trace evaluation of sulfonic acids, determination of magnesium in steel, Prep work of oximes by natural synthesis. Color photo processing. driver. swelling representative. Copolymerization prevention.
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Application of Hydroxylamine Hydrochloride
CN201510189160.X discloses a preparation and purification method of erythromycin oxime. The reaction product of erythromycin oxime is prepared by reacting methanol, hydroxylamine hydrochloride and erythromycin thiocyanate to prepare the filtered mother liquor of the reaction product in erythromycin oxime, and red thiocyanate is added to it. Mycin, methanol and hydroxylamine hydrochloride, the added amount of hydroxylamine hydrochloride is 0.1-10 times the molar amount of erythromycin thiocyanate, the amount of methanol added is 0.1-0.5 times the volume of the mother liquor, and the amount of erythromycin thiocyanate is 0.1-0.5 times. The amount of addition is 0.5-1 times of the volume of the mother liquor, then the pH of ammonium bicarbonate is added to 6-7, and then the oximation reaction is carried out. Obtain the wet product of erythromycin oxime salt, then add alkali to free erythromycin oxime to obtain erythromycin oxime, repeat the above steps, and recycle the reaction mother liquor 1-10 times, so as to maximize the utilization of erythromycin thiocyanate and hydroxylamine hydrochloride. yield, reduce waste discharge, and reduce costs.
CN201911070018.8 reported a preparation method of octanoyl hydroxamic acid, comprising the following steps: Step 1: Mix hydroxylamine hydrochloride and methanol to prepare a methanol solution of hydroxylamine hydrochloride with a certain concentration; Hydroxylamine hydrochloride methanol solution, liquid sodium methoxide, and methyl octanoate are added to the reactor, and under the condition of normal pressure and a reaction temperature of 60 to 75 ° C, the oximation reaction is carried out for 300 seconds to 3 hours; Step 3: The solution after step 2 is reacted The temperature is lowered to 15-30° C., hydrogen chloride gas is introduced into the solution until the pH value of the solution is 2-4, and then the octanoylhydroxamic acid product is obtained after centrifugation, concentration, crystallization, centrifugation and drying. The invention adopts liquid sodium methoxide as the raw material for synthesizing octanoyl hydroxamic acid, which not only greatly improves the yield of the product, but also has high product purity and few impurities, and no waste water is generated in the synthesis process, thus reducing the production cost and being more environmentally friendly.
Preparation of Hydroxylamine Hydrochloride
The first step, ketoxime synthesis: 5 kg of Ti-MWW molecular sieve, 36 kg of butanone, and 100 kg of water were added to the reactor together, heated to 60 °C in a water bath, and then 75 kg of ammonia water and 68 kg of hydrogen peroxide were added to the reactor. The uniform rate was added to the reactor within 90 minutes, keeping the water bath temperature and stirring speed unchanged throughout the process. After the reaction was completed, the unreacted ammonia was absorbed under reduced pressure. The butanone oxime is extracted, and the obtained butanone oxime is mixed with the oil phase to obtain a crude butanone oxime.
The second step, the preparation of hydroxylamine hydrochloride: take 45 kilograms of water, add 13.5 kilograms of ammonium chloride, add 43 kilograms of crude butanone oxime obtained in the first step, heat it to 70 ° C to make it react, depressurize to a vacuum degree of 100KPa and absorb the reaction to generate The ammonia and methyl ethyl ketone were kept at 70°C for 6 hours, and after cooling to 0°C, the lower water phase was released with a separating funnel after standing, and the unreacted butanone oxime was extracted with ether, and the obtained aqueous phase was Hydroxylamine hydrochloride aqueous solution. The hydroxylamine hydrochloride aqueous solution is frozen and precipitated at -10°C, filtered and suctioned to obtain hydroxylamine hydrochloride crystals, and then the filtrate is evaporated and concentrated under negative pressure, and then subjected to cold precipitation, repeated several times, and the obtained hydroxylamine hydrochloride crystals are weighed together. 16 kg of hydroxylamine hydrochloride crystals, the yield is 92% based on ammonium chloride.
The unreacted ammonia gas absorbed in the first step under reduced pressure, the ammonia gas and butanone generated by the reaction under reduced pressure absorption in the second step can be reused in the first step. In the second step, the diethyl ether extract was evaporated to remove diethyl ether, and then combined with the upper oil as unreacted crude butanone oxime for reuse in the second step.
- Hydroxylamine hydrochloride – PubChem
- [Chinese invention, Chinese invention authorization] CN201710541998.X A kind of method for preparing hydroxylamine hydrochloride
Hydroxylamine Hydrochloride Supplier and Manufacturer
As a hydroxylamine hydrochloride supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best hydroxylamine hydrochloride raw materials to customers all over the world.
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