Basic Info
Model No.: LYN-1397-89-3
CAS: 1397-89-3
Name:: Amphotericin B
Shelf Life: 2 Years
Sample: Available
Additional Info
Packaging: 25kg/Drum
Productivity: 10000kg
Brand: zhishang
Transportation: Ocean,Land,Air
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 1060.24000
Port: Shanghai,Tianjin,Qingdao
Product Description
High quality CAS:1397-89-3.Amphotericin B
Product Introduction
Product Name Amphotericin B
Molecular Formula C47H73NO17
Molecular Weight 924.079
CAS Registry Number 1397-89-3
EINECS 215-742-2
Density 1.34g/cm3
Melting point >170°C
Boiling point 1140.365°C at 760 mmHg
Refractive index 1.614
Flash point 643.47°C
Water solubility <0.1 g/100 mL at 21°C
Vapour Pressur 0mmHg at 25°C
Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical’s amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more activein vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.
Currently, the drug is available as plain amphotericin B, as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B.
Specification
Tests | Specifications | Results | |
Appearance | Yellow to orange powder, odorless or practically so. | Yellow powder | |
Solubility | Insoluble in water and in ether,slightly soluble in methanol | Complies | |
Identification A: (UV) | Conforms to standard; absorbance in the range of 240nm to 320nm | Complies | |
Identification B: (UV/Vis ) | Conforms to standard; absorbance in the range of 320nm to 400nm | Complies | |
Loss on drying | Not more than 5.0% | 1.5% | |
Residue on Ignition | Not more than 3.0% | 0.4% | |
Limit amphotericin A | Not more than 15.0% | Not detected | |
Assay (microbial) | Not less than 750 μg/mg calculated on the dried basis | 894 μg/mg | |
Residual Solvents | Ethanol | Not more than 5000 ppm | 3309ppm |
Acetone | Not more than 5000 ppm | 1346ppm | |
Conclusion | Complies with USP34 | ||
Function
Antifungal
Oral preparations of amphotericin B are used to treat thrush; these are virtually nontoxic, in contrast to typical intravenous therapy (IV) doses.
One of the main intravenous uses is in treating various systemic fungal infections (e.g., in critically ill, comorbidly infected or immunocompromised patients), including cryptococcal meningitis.
Amphotericin B is also commonly used in tissue culture to prevent fungi from contaminating cell cultures. It is usually sold in a concentrated solution, either on its own or in combination with the antibiotics penicillin and streptomycin.
Antiprotozoan
Another IV use is as a drug of last resort in otherwise-untreatable parasitic protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis.
Package
0.5kgs/Al-foil bag
1.0kgs/Al-foil bag
2.0kgs/Al-foil bag
5.0 kgs/Al-foil bag
25.0 kgs/drum
or upon customers’ request
