High purity Plant Extract Paclitaxel 99%(CAS:33069-62-4)

Basic Info

Model No.: LYN- 33069-62-4

Shelf Life: 2 Years

Form:: Powder

CoA: Available

Sample: Free

CAS: 611-72-3

Name:: L-Mandelic Acid

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

Port: Shanghai,Tianjin,Qingdao

Product Description

High purity Plant Extract Paclitaxel 99%(CAS:33069-62-4) 

Introduction:

 

Natrual Paclitaxel 99.5% HPLC 

 

Standard: USP 32

 

Appearance: white crysaline powder

 

Mole formular: C47H51NO14  

 

CAS:33069-62-5

 

Melting point: 213-216 degree 

 

Natural Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it ‘taxol’. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to ‘paclitaxel’ and the BMS compound is sold under the trademark ‘TAXOL’. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent.

 

 

Function:

 

1. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi’s sarcoma.  
4. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents. 

 

Specification: 

 

Tests

Standards

Results

Appearance

 white powder 

Wcrystalline powder.hite, 

Identification

A:IR absorption

Complies

Complies

B:UV absorption

Complies

Complies

C:TLC

Complies

Complies

Melting point

168~172°C

169.0~170.9°C

Water

Not more than0.5%

0.08%

Related substance

ImpurityJ(chloroacetanilide)not more than 10 ppm 

2ppm

Impurity K(4-aminophenol)not more than 50 ppm

15 ppm

Impurity F(4-nitrophenol)not more than 0.05%

Not detected

any other impurity not more than 0.05%

0.01%

Total of other impurities not more than 0.1%

0.02%

Residue on ignition

Not more than 0.1%

0.05%

Chloride

Not more than 0.014%

Less than 0.014%

Sulfate

Not more than 0.02%

Less than 0.02%

Sulfide

Conforms

Conforms

Heavy metals

Not more than 0.001%

Less than 0.001%

Free p-aminophenol

Not more than 0.005%

Less than 0.005%

Limit of P-chloroacetanilide

Not more than 0.001%

Less than 0.001%

Readily carbonizable substances

Conforms

Conforms

Residual solvents

Residual content of acetic acid is limited

 by the test of loss on dryingnot more than0.5%

0.08%

Assay(anhydrous basis)

99.0~101.0%

99.6%

Conclusion:   Complies with USP34/ BP2011

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