Good quality prostaglandin E1 745-65-3

Basic Info

Model No.: CAS NO 745-65-3

Name:: Prostaglandin E1

CAS:: 745-65-3

MF:: C20H34O5

MW:: 354.48100

Density:: 1.321 G/mL At 25 °C (lit.)

MP:: 115-116 °C

Bp:: 529.3ºC At 760 MmHg

FP:: 288ºC

Refractive Index:: Undissolved

Additional Info

Packaging: as your requirement

Productivity: 1000kg per Month

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

HS Code: 745-65-3

Port: Shanghai,Qingdao,Tianjin

Product Description

Good quality prostaglandin E1 745-65-3


Prostaglandin E1 (PGE1), also known as Alprostadil, is a prostaglandin that is commonly used for the treatment of erectile dysfunction, vasodilation, and the like.

production method

The use of sheep seminal vesicle as raw material PGE crude preparation Sheep seminal vesicles were prepared by enzyme preparation, incubation, organic solvent extraction and silica gel column separation. Sheep seminal vesicle [KCl, EDTANa2, Ph8] → Enzyme suspension [hydroquinone, glutathione] → [arachidonic acid, O2] reaction solution [acetone, ether, methylene chloride] → PGS Crude [Separated] → [Silicone column] Preparation of PGE crude PGE1 product: Use 20 g of silica gel per 1 g of PGE crude product, take 200-250 mesh of 10x PGE-quality activated silver nitrate on silica gel, and suspend in V ethyl acetate: V glacial acetic acid: V Petroleum ether: V water 1 and PGE2 sections. The PGE1 portion was concentrated under nitrogen at 35° C. until no acetic acid was added. Ethyl acetate was added to dissolve the solution. The acid was added with water, pH 4-5, and silver was added to normal saline. The ethyl acetate solution was placed in a refrigerator overnight to obtain a PGE1 product. PGE crude [silver nitrate silica gel column]→PGE
1 Liang Yongtao, Wei Fengping and others used gamma-linolenic acid methyl ester as the starting material and adopted chemical-enzymatic synthesis technology to synthesize prostaglandin E1 via two different routes. The total yield was 13% and 16% respectively.
Hepatitis Cirrhosis, Cerebral Infarction, Diabetes, Impotence, Respiratory Diseases. For childrenA, B patients with severely impaired liver function, especially for childA patients, they have antifibrotic effects. For induction of labor, oxytocin, renal insufficiency, mumps, pancreatitis, etc. Prostaglandin E1 for injection is mainly used for myocardial infarction, heart failure, thrombotic vasculitis, chronic arterial occlusive disease, central retinal vein thrombosis, and is used for extracorporeal circulation to protect platelets, arteriography, and revascularization.

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.

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