Model No.: CAS NO 745-65-3
Name:: Prostaglandin E1
Density:: 1.321 G/mL At 25 °C (lit.)
MP:: 115-116 °C
Bp:: 529.3ºC At 760 MmHg
Refractive Index:: Undissolved
Packaging: as your requirement
Productivity: 1000kg per Month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 745-65-3
Good quality prostaglandin E1 745-65-3
Prostaglandin E1 (PGE1), also known as Alprostadil, is a prostaglandin that is commonly used for the treatment of erectile dysfunction, vasodilation, and the like.
The use of sheep seminal vesicle as raw material PGE crude preparation Sheep seminal vesicles were prepared by enzyme preparation, incubation, organic solvent extraction and silica gel column separation. Sheep seminal vesicle [KCl, EDTANa2, Ph8] → Enzyme suspension [hydroquinone, glutathione] → [arachidonic acid, O2] reaction solution [acetone, ether, methylene chloride] → PGS Crude [Separated] → [Silicone column] Preparation of PGE crude PGE1 product: Use 20 g of silica gel per 1 g of PGE crude product, take 200-250 mesh of 10x PGE-quality activated silver nitrate on silica gel, and suspend in V ethyl acetate: V glacial acetic acid: V Petroleum ether: V water 1 and PGE2 sections. The PGE1 portion was concentrated under nitrogen at 35° C. until no acetic acid was added. Ethyl acetate was added to dissolve the solution. The acid was added with water, pH 4-5, and silver was added to normal saline. The ethyl acetate solution was placed in a refrigerator overnight to obtain a PGE1 product. PGE crude [silver nitrate silica gel column]→PGE
1 Liang Yongtao, Wei Fengping and others used gamma-linolenic acid methyl ester as the starting material and adopted chemical-enzymatic synthesis technology to synthesize prostaglandin E1 via two different routes. The total yield was 13% and 16% respectively.
Hepatitis Cirrhosis, Cerebral Infarction, Diabetes, Impotence, Respiratory Diseases. For childrenA, B patients with severely impaired liver function, especially for childA patients, they have antifibrotic effects. For induction of labor, oxytocin, renal insufficiency, mumps, pancreatitis, etc. Prostaglandin E1 for injection is mainly used for myocardial infarction, heart failure, thrombotic vasculitis, chronic arterial occlusive disease, central retinal vein thrombosis, and is used for extracorporeal circulation to protect platelets, arteriography, and revascularization.