Model No.: CAS NO 105-36-2
Status: Liquid Catalyst
Response Type: Polymerization
Classification: Homogeneous Catalysts
Usage: Negative Catalyst
Effect Size: Promoter Catalysts
Manufacturing Method: Mechanical Mixing
Application Industry: Physiology
Name:: Ethyl Bromoacetate
MP:: -38 °C
Bp:: 159 °C(lit.)
FP:: 118 °F
Packaging: in 25kg drum
Productivity: 10000kg per month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 105-36-2
Good quality Ethyl bromoacetate CAS no 105-36-2
Ethyl 2-bromoacetate is the chemical compound with the formula CH2BrCO2C2H5. It is the ethyl ester of bromoacetic acid and is prepared in two steps from acetic acid. It is a lachrymator and has a fruity, pungent odor. It is also a highly toxic alkylating agent and may be fatal if inhaled.
1. Obtained from the bromination of hexanediol: In a 500 mL flask with a reflux condenser, 58 g of 1,6-hexanediol and 6.84 g of red phosphorus were added. The mixture was heated to 100-150°C with stirring, and 80 g of bromine was added dropwise. After the addition was complete, stirring was continued at this room temperature for 1 h. The reaction was cooled to room temperature and diluted with water. Add 100 mL of ether and filter off excess red phosphorus. The dibromide solution in diethyl ether was separated and washed sequentially with 10% sodium sulfate solution and water. Dry with anhydrous calcium chloride. Distilling off the ether, vacuum distillation, collecting 114 ~ 115 ° C (1.6kPa) fractions, to obtain the finished product 85g, the yield was 71%.1. Prepare bromoacetic acid by reacting bromine with acetic acid and acetic anhydride in pyridine, and then react with bromoacetic acid and ethanol in the presence of sulfuric acid to form ethyl bromoacetate. It is generally prepared in two steps. 1 Preparation of bromoacetic acid: 3L glacial acetic acid and 100mL acetic anhydride were added to the flask, and 15g of red phosphorus or 70g of phosphorus tribromide was added, heated to 100°C with stirring, and 300mL (900g, 5.6mol) was slowly dropped from the separating funnel. ) Bromide, the reaction has an induction process, do not add too fast, so as to avoid sudden reactions. After the start of the reaction (with HBr released), maintain a temperature between 90°C and 100°C, and slowly add 2.0L of bromine (2.3L in total, 41 mol). After the addition, continue stirring and heating to turn the brown-red liquid into orange red. Since then, it has rarely been released. Unreacted acetic acid was recovered to a distillation temperature of 140°C and approximately 1L was recovered for the next synthesis. 2Esterification: The crude bromoacetic acid was poured into another 10L flask, 5L of industrial ethanol and 200 mL of sulfuric acid were added, refluxed on a boiling water bath for 12 hours, ethanol was recovered, washed with saturated brine three times, and dried after drying over anhydrous sodium sulfate. , collect 154 ~ 158 ° C distillate, get 2.4 ~ 2.6kg.
2. Method: Add bromoacetic acid to the reaction flask with the trap
(2) 220 g (1.58 mol), 155 mL of anhydrous ethanol (2.66 mol), 240 mL of toluene and 1 mL of concentrated sulfuric acid, and zeolite was further added. Heat reflux, water, toluene, ethanol layered in the water separator, toluene back to the reaction flask, the lower layer, about collected 75mL. Ethanol 20 mL was added and reflux reaction was continued for 0.5 h. Evaporate ethanol and toluene as much as possible. The reaction was poured into water and allowed to stand for delamination. Separate the aqueous layer, and then washed with 5% sodium bicarbonate and water, dried over anhydrous sodium sulfate, fractionally distilled, and collect the distillate from 164 to 168°C to obtain ethyl bromoacetate.
Used as medicine, pesticide intermediates.
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Answer: Yes, we have our own factory called [ZhiShang Industry Group “, we export by ShandongZhishangchemical Co., Ltd.
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