Model No.: ELLEN-CAS 912-60-7
Shelf Life: 2 Years
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
1).Noscapine hydrochloride is the hydrochloride form of Noscapine.
2).Noscapine is an opioid alkaloid with several actions.
Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.
3).Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis.
Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway.
4).Noscapine hydrochloride is an inhibitor of Tubulin.
|Characters||White or almost white, crystalline powder or colourless crystals.Practically insoluble in water, soluble in acetone, slightly soluble in alcohol. It dissolves in strong acids;on dilution of the solution with water, the base may be precipitated||Confirms|
|Identification||According to BP 2010||Confirms|
|Appearance of solution||The solution is clear and not more intensely coloured than reference solution Y6||Confirms|
|Specific optical rotation||+ 42 to + 48 (dried substance)||+45.5|
|Related substances||impurity A: NMT 0.5%||Not detected|
|any other impurity: NMT 0.2%||Not detected|
|total of other impurities: NMT 0.5%||Not detected|
|Loss on drying||Maximum 1.0%||0.04%|
|Sulphated ash||Maximum 0.1%||0.06%|
|Assay||99.0 per cent to 101.0 per cent (dried substance).||100.05%|