GMP plant high quality Noscapine hydrochloride Cas:912-60-7 with best price

Basic Info

Model No.: ELLEN-CAS 912-60-7

Shelf Life: 2 Years

Form:: Powder

CAS: 912-60-7

Name:: Nakeding

CoA: Available

Sample: Free

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

Port: Shanghai,Tianjin,Qingdao

Product Description

1).Noscapine hydrochloride is the hydrochloride form of Noscapine.

 

2).Noscapine is an opioid alkaloid with several actions.

Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

 

3).Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis.

Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway.

 

4).Noscapine hydrochloride is an inhibitor of Tubulin.

 

 

Item Standard Result
Characters White or almost white, crystalline powder or colourless crystals.Practically insoluble in water, soluble in acetone, slightly soluble in alcohol. It dissolves in strong acids;on dilution of the solution with water, the base may be precipitated Confirms
Identification According to BP 2010 Confirms
Appearance of solution The solution is clear and not more intensely coloured than reference solution Y6 Confirms
Specific optical rotation + 42 to + 48 (dried substance) +45.5
Related substances impurity A: NMT 0.5% Not detected
  any other impurity: NMT 0.2% Not detected
  total of other impurities: NMT 0.5% Not detected
Loss on drying Maximum 1.0% 0.04%
Sulphated ash Maximum 0.1% 0.06%
Assay 99.0 per cent to 101.0 per cent (dried substance). 100.05%

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