GMP manufacture Taxol CAS 33069-62-4

Basic Info

Model No.: LYN- 33069-62-4

Shelf Life: 2 Years

Form:: Powder

CAS: 33069-62-4 ​

Name:: Taxol

CoA: Available

Sample: Free

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

Port: Shanghai,Tianjin,Qingdao

Product Description

GMP manufacture Taxol CAS 33069-62-4 

Description

Product Introduction

  Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it ‘taxol’. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to ‘paclitaxel’ and the BMS compound is sold under the trademark ‘TAXOL’. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.

Specification :

Tests

Standards

Results

Appearance

 white powder

Wcrystalline powder.hite,

Identification

A:IR absorption

Complies

Complies

B:UV absorption

Complies

Complies

C:TLC

Complies

Complies

Melting point

168~172°C

169.0~170.9°C

Water

Not more than0.5%

0.08%

Related substance

ImpurityJ(chloroacetanilide)not more than 10 ppm

2ppm

Impurity K(4-aminophenol)not more than 50 ppm

15 ppm

Impurity F(4-nitrophenol)not more than 0.05%

Not detected

any other impurity not more than 0.05%

0.01%

Total of other impurities not more than 0.1%

0.02%

Residue on ignition

Not more than 0.1%

0.05%

Chloride

Not more than 0.014%

Less than 0.014%

Sulfate

Not more than 0.02%

Less than 0.02%

Sulfide

Conforms

Conforms

Heavy metals

Not more than 0.001%

Less than 0.001%

Free p-aminophenol

Not more than 0.005%

Less than 0.005%

Limit of P-chloroacetanilide

Not more than 0.001%

Less than 0.001%

Readily carbonizable substances

Conforms

Conforms

Residual solvents

Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%

0.08%

Assay(anhydrous basis)

99.0~101.0%

99.6%

Conclusion:   Complies with USP34/ BP2011

 

  Function 

    Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi’s sarcoma. Paclitaxel is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes .

Application

Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.


Leave a Comment

Your email address will not be published.

Scroll to Top