Clavulanic acid is a beta-lactam drug that acts as a mechanism-based beta-lactamase inhibitor. Although not effective as an antibiotic itself, it can overcome the antibiotic resistance of bacteria secreting β-lactamase when used in combination with penicillin antibiotics, otherwise β-lactamase will inactivate most penicillin.
1. Hemolytic streptococcus, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, or upper respiratory tract infection due to otitis media, sinusitis, pharyngitis, tonsillitis.
2. Escherichia coli, Enterococcus faecalis, Proteus mirabilis.
3. Hemolytic streptococcus, staphylococcal or E. coli-induced skin and soft tissue infections.
4. Hemolytic streptococcus, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, or acute bronchitis, pneumonia and other lower respiratory tract infections (5) Acute simple gonorrhea (6) for the treatment of Salmonella infections such as typhoid fever, Typhoid and carrier leptospirosis; laoxoprazo may be amoxicillin and clarithromycin.