Glabridin CAS 59870-68-7
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Glabridin Supplement
Glabridin: The Complete Guide
Glabridin for Sale
Basic Info of Glabridin
Glabridin powder; Glabridin cas 59870-68-7
Pesticide raw materials; Plant extracts; Cosmetic raw materials; Daily chemicals; Pharmaceutical raw materials
What is Glabridin?
Glycyrrhiza glabra L. is a perennial herb, mainly distributed in northern Xinjiang, Qinghai, Gansu and other provinces. It is rich in resources and has wild and artificial cultivation bases with large reserves. Its main components are triterpenoid saponins such as glycyrrhizic acid, glycyrrhetic acid, and glycyrrhizin, and flavonoids such as liquiritigenin and isoliquiritigenin. Efficacy, can anti-inflammatory, anti-virus, liver protection, inhibit HIV and improve the body’s anti-tumor ability.
Glycyrrhiza glabra is a unique isoflavone component of Glycyrrhiza glabra, accounting for about 11% of the total flavonoids of Glycyrrhiza glabra. , liver protection, scavenging free radicals and other effects, but also has a certain role in lowering blood lipids and lowering blood pressure. In the prevention and treatment of arteriosclerosis and cardiovascular disease, it also shows a good prospect of medicinal development. Glycyrrhiza glabra is a whitening cosmetic additive launched by Japan’s MARUZEN company in 1989. Now many well-known companies at home and abroad also use licorice as the main additive for their whitening, freckle and nutritional health care products. Because of its important physiological activity, it has high potential application value. However, only 100g of Glycyrrhiza can be obtained in 1000kg of Glycyrrhiza glabra. Due to scarcity and difficulty in extraction, 1g of Glycyrrhiza is equivalent to 1g of physical gold, and is known as “whitening gold”.
- Glycyrrhiza has strong oxidative impact, anti-atherosclerosis as well as particular effect of decreasing blood lipid and blood pressure.
- Glycyrrhizin is a substance removed from licorice (origin) with cytotoxic, antibacterial, estrogenic as well as antiproliferative residential properties.
- Glycyrrhizin is a bioavailable isoflavane separated from the root extract of Glycyrrhiza glabra L. It has been reported that glycyrrhizin has a range of biological activities, consisting of strong antioxidant task, anti LDL oxidation antioxidant, anti Helicobacter pylori building, estrogen like task, anti nephritis and free radical scavenging task. It likewise appears to inhibit serotonin reuptake, melanogenesis, swelling, as well as cytochrome P450 3A4, 2b6, as well as 2C9.
- Glycyrrhizin has solid antibacterial homes, protects against inflammation, pigmentation as well as harsh skin caused by ultraviolet rays, can get rid of superoxide ions, hinder hemolysis caused by hydrogen peroxide, can hinder the activity of tyrosinase, as well as can It hinders the task of dopa pigment interconversion and also DHICA oxidase. It is a quickly, reliable and environment-friendly cosmetic additive for bleaching and blemish elimination. It has the capacity to feed on oxygen totally free radicals similar to turf (superoxide dismutase). Antioxidative cost-free radical capacity similar to vitamin E.
- Glabridin has excellent anti-inflammatory, bacteriostatic, anti-oxidative and anti-melanin-forming effects. It can penetrate deep into the skin and maintain high activity. It whitens and has high-efficiency anti-oxidation. It also has the effects of preventing skin roughness. whitening ingredients. It is widely used in anti-blackening care after laser laser operation, medical skin care products and various cosmetics.
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Application of Glabridin
- Whitening, inhibiting melanin
The major device of action of licorice in inhibiting melanin is the inhibition of tyrosinase, which is an important enzyme in the human body, which can consistently create melanin and also transform the skin or eyes from brownish to black. We understand that skin exposure to UV light can cause some reactions (such as swelling), due to the destruction of the phospholipid membrane layer of skin cells by UV-induced responsive oxygen types, this histological change appears as erythema and also coloring. Active oxygen is a substance that can create skin coloring, so hindering its manufacturing can inhibit the manufacturing of melanin.
- Anti-inflammatory effect
The anti-inflammatory activity of Glycyrrhizin was validated by experiments. The test subject were irradiated with ultraviolet light to create coloring, and after that smeared with 0.5% Glycyrrhizin solution. It was found that Glycyrrhizin minimized the skin inflammation caused by ultraviolet excitement. Erythema on the skin is represented by a value. The level of inflammation reduction can be determined by taping the alpha value (colorimetric analysis) of glabridin before and after irradiation.
The scientists examined the activity of glabridin to hinder cyclooxygenase. Cyclooxygenase is an enzyme that converts arachidonic acid right into prostaglandins, which are pro-inflammatory factors. Compared to the control group (using the existing cyclooxygenase prevention, indenemethine), licorice can achieve the result of inhibiting cyclooxygenase. It is believed that glabridin influences the manufacturing of arachidonic acid by hindering cyclooxygenase, consequently lowering inflammation.
- Antioxidant effect
Individuals frequently count on constant breathing to obtain oxygen. Nevertheless, when the body is utilizing oxygen to execute certain metabolic reactions, it will undoubtedly generate some uncertain substances, and these unstable materials are all “transformations” of oxygen. The individuality is extremely energetic as well as likes to attack other useful cells. It is the devastating element of the body. When the focus of cost-free radicals in the body is not really high, our body has a complete system to eliminate these totally free radicals. Nevertheless, if the focus of cost-free radicals continues to increase, the antioxidant system in our body will deal with a crisis of not enough use.
What takes place to oxidized skin?
The oxidation process of apples is actually comparable to that of human skin, which is why the face of the senior will be wrinkled. Glycyrrhizin has antioxidant residential or commercial properties. It has been reported in the literature that licorice can additionally be made use of to lower corticosteroids in transmittable skin diseases as well as can boost the impact of steroids.
Glabridin Inhibits Melanin
- Inhibit tyrosinase
Human tyrosinase is a necessary enzyme that frequently produces melanin, which transforms the skin or eyes from brownish to black. We understand that skin exposure to UV light can cause some responses (such as inflammation), due to the devastation of the phospholipid membrane of skin cells by UV-induced responsive oxygen varieties, this histological change appears as erythema and also hyperpigmentation. Energetic oxygen is a material that can trigger skin pigmentation, so preventing its manufacturing can prevent the production of melanin. Glycyrrhizin is the most pricey as well as most effective whitening active ingredient among all lightening active ingredients. According to “Ben Cao Zhonghua”, the whitening effect of Glycyrrhizin is 232 times that of normal vitamin C as well as 16 times greater than that of hydroquinone. “Arbutin “1164 times, so licorice is called “whitening gold”.
- Anti-inflammatory impact
The anti-inflammatory activity of Glycyrrhizin was confirmed by experiments. The guinea pigs were irradiated with ultraviolet light to trigger pigmentation, and then smeared with 0.5% Glycyrrhizin solution. It was found that Glycyrrhizin minimized the skin inflammation caused by ultraviolet excitement. Erythema on the skin is stood for by a worth. The level of swelling decrease can be determined by videotaping the alpha worth (colorimetric analysis) of glabridin prior to as well as after irradiation. The researchers studied the activity of glabridin to prevent cyclooxygenase. Cyclooxygenase is an enzyme that converts arachidonic acid into prostaglandins, which are pro-inflammatory aspects. Compared to the control group (using the current cyclooxygenase prevention, indenemethine), Glycyrrhizin can prevent cyclooxygenase. It is believed that glabridin influences the production of arachidonic acid by preventing cyclooxygenase, thereby reducing inflammation.
- Anti-oxidize result
Glycyrrhiza has a strong scavenging result on complimentary radicals. Vitamin C, vitamin E and β-carotene are acknowledged as the three kings of anti-oxidation and also anti-aging. It is reported that the antioxidant result of its antioxidants is significantly better than that of BHA and BHT. It has actually been reported in the literature that licorice can be used to decrease corticosteroids in transmittable skin diseases and can enhance the effect of steroids.