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Ethyl Cellulose CAS 9004-57-3

Factory Supply Ethyl Cellulose CAS 9004-57-3 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Ethyl Cellulose Supplier & Manufacturer

Basic Info

What is Ethyl Cellulose?

Ethyl ester of cellulose. White to light gray liquid paste, thermoplastic. It is unpredictable to heat, modifications shade and also sheds its original physical as well as chemical residential or commercial properties at high temperature (240 ° C). Viscosity should be specified for commercial quality items. The relative thickness is 1.07-1.18, the refractive index is 1.47, as well as the softening factor is 100-130 ° C. It can develop difficult movies and also preserve flexibility at low temperatures. Can be blended with resins, waxes, oils, and so on. Stable to alkali as well as thin down acid.

The softening factor as well as hygroscopicity decline with the increase of ethoxy material. The ethoxy content of common items is 47% to 48%. Almost insoluble in water, glycerin and also propylene glycol, however soluble in some organic solvents to varying levels (relying on the material of ethoxy teams). Ethyl cellulose with an ethoxy material of less than 46% to 48% is conveniently soluble in a mix of tetrahydrofuran, methyl acetate, chloroform and also fragrant hydrocarbon-ethanol. Those with an ethoxy material higher than 46% to 48% are quickly soluble in ethanol, methanol, toluene, chloroform as well as ethyl acetate. The litmus test of 5% suspension was neutral.

Ethyl cellulose is a derivative of cellulose, in which some hydroxyl groups on duplicated sugar systems are converted to ether groups. The amount of ethyl might vary from supplier to supplier.

Ethyl Cellulose Uses

  1. Tablet computers (primarily utilized for vitamins and also inorganic salts); binders for vitamin powders; fillers.
  2. Ethyl cellulose is also used as food additive as emulsifier (E462).
  3. Ethyl cellulose is mainly used as film coating material for paper, vitamins and pills, as well as thickener in cosmetics and industrial processes.
  4. Food grade ethyl cellulose is one of the few non-toxic films and thickeners that are insoluble in water. This attribute allows it to be used to protect ingredients from water.
  5. It is used as glue and filler in dried out vitamin preparations, as a component of safety layer for minerals and vitamin tablets, and also as a fixative in flavor compounds. It is a cellulose ether including ethoxy groups attached by ether bonds, and also each dried sugar unit consists of no more than 2.6 ethoxy anhydrous bases.

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Application of Ethyl Cellulose

Ethyl cellulose is extensively utilized in coverings. It can additionally be made use of as the basic material of strong lubes for marking metal workpieces. In microcircuit printing, ethyl cellulose is made use of as a vehicle. In the radio sector, it is used as an innovative insulating product, and as a special movie in safety coverings, such as the cladding layer of rocket propellants. It can be made use of as hot-melt adhesives and layers for cords, paper, textiles, and so on, along with insulation for extruded cords as well as durability enhancers for plastics. It can also be used in pigment grinding bases, publishing inks, built plastic powders, eruptive fuzes, as well as solutions of vitamins, etc. Utilized as a peelable layer to safeguard metal parts from rust and spoiling before utilize, and as a peelable coating to safeguard breakable glasses. There are still several uses in adhesives, fabrics and also fibers, medication and also food, as well as various other markets. Industrial grade ethyl cellulose is utilized in coatings (gel coatings, hot-melt coatings), inks (display printing inks, gravure printing inks), adhesives, pigment pastes, etc. High-end items are utilized in medication, cosmetics and also food, such as pharmaceutical tablet product packaging products, binders for long-acting prep work, etc.

Preparation Applications of Ethyl Cellulose

Ethyl cellulose is widely used in oral and topical formulations. In oral preparations, ethylcellulose is mainly used as a hydrophobic coating material and sustained-release matrix material for tablets and granules. The main purpose of coating with ethyl cellulose is to adjust the release rate of the drug, mask bad odors and increase the stability of the preparation. For example, granules can be coated with ethylcellulose to prevent oxidation, and sustained-release tablets can use ethylcellulose as a matrix material.

Ethyl cellulose is an insoluble film coating material that has the functions of moisture-proof, light-proof, odor-masking, sustained release and improved fluidity. Ethylcellulose has good film-forming properties, good tensile strength and elasticity, and the ability to change drug release, so it has been widely studied as a coating agent.

When using ethyl cellulose coating, generally the tablet size can be increased by about 6% to obtain a better sustained-release effect (the coating weight increase is greatly affected by the size of the tablet core. If the tablet core or pill core is larger Small, then the surface area is relatively large, and a large coating weight gain is required to meet the demand). Ethylcellulose-coated pellets and granules can withstand a certain amount of pressure and can protect the coating layer from rupture during tableting.

Some topical formulations, such as ocular formulations and transdermal formulations, can utilize ethylcellulose to achieve sustained release. Ocular drug delivery formulations are a highly demanding dosage form in pharmaceutical technology. In order to improve ocular bioavailability, scientists have designed sustained-release drug dosage forms, such as hydrogels or microtablets. Ethylcellulose alone or in combination with hydrophilic excipients can be used as a sustained-release matrix material for drugs. By adjusting the proportion of ethylcellulose in the prescription, the release rate of the drug can be controlled. As its dosage increases, the release rate of the drug decreases.

Ethylcellulose has the effect of slowing down drug dissolution. This is because the water-insoluble skeleton composed of ethylcellulose is not easily wetted by water, which can reduce drug dissolution; and the drug particles are evenly dispersed in the skeleton structure, and the dissolution medium can only pass through The micropores in the skeleton penetrate, gradually dissolve the drug and diffuse outward, achieving a sustained release effect.

Microcapsules or nanocapsules are common methods to change drug release. They encapsulate drugs in polymers, which not only achieves sustained release of drugs, but also improves the bioavailability of drugs, reduces side effects, and improves drug stability. High viscosity ethylcellulose can be used for drug microencapsulation. The drug release process from ethylcellulose-coated microcapsules is related to the microcapsule wall thickness and surface area.

Bioadhesive preparations are pharmaceutical preparations in which drugs use hydrogel polymers as carriers and adhere to mucous membranes for a long time through bioadhesion to exert therapeutic effects. At present, people have developed various preparations such as bioadhesive powders, tablets, gels, liposomes and microspheres, and oral ulcer adhesive films and tablets containing hormones are available abroad. The application of bioadhesive preparations has achieved very significant results in extending drug action time, reducing adverse drug reactions, and improving drug bioavailability. When developing bioadhesive formulations, selection of appropriate polymers with adhesive properties is key. Polymers that are bioadhesive and do not dissolve prior to drug release are ideal for use in sustained-release drug formulations.

As a water-insoluble polymer, ethylcellulose is often used as a back film due to its film-forming properties, low water permeability, drug impermeability and moderate flexibility. It is bioadhesive, but less so than carbomer and chitosan. When the formulation comes into contact with water, ethylcellulose forms a hydrophobic network that allows sustained release of the drug. Drug-loaded ethylcellulose membrane has good adhesion, mechanical strength and sustained-release properties. Its performance can be adjusted by the amount of porogen, film thickness and ethylcellulose molecular weight.

Ethylcellulose can be used as a drug carrier to prepare microspheres or solid dispersions through emulsification-solvent evaporation method, phase coagulation method, solvent method or spray drying method. Contrary to the usual fast-acting and bioavailability-enhancing effects of solid dispersions, ethylcellulose can slow the dissolution rate of the drug. In solid dispersion systems, drug particles are introduced into an ethylcellulose carrier to control drug release.

Ethyl cellulose has good adhesion properties and can be used as a binder. In tablets, ethylcellulose can be used as a binder by dry mixing or by wet mixing with 95% ethanol as a solvent. Its hydrophobicity also makes high-viscosity ethylcellulose have obvious drug-release retardation properties when used as a binder. Therefore, the plain tablets made with ethyl cellulose have a hard texture and low brittleness, but have poor dissolution.

Due to the complex active ingredients of traditional Chinese medicines and traditional Chinese medicine compounds, the application of ethylcellulose in traditional Chinese medicine preparations [8] is still in the research stage, mainly focusing on sustained-release film coating materials, skeleton adhesive materials, solid dispersion carriers, etc. The ultimate goal of research on ethyl cellulose is to improve the efficacy of traditional Chinese medicine by controlling the drug release rate, reduce the frequency of medication, solve the problems of traditional Chinese medicine being highly hygroscopic and prone to mildew, and achieve the requirements of high efficiency, long-term effect, and low toxic and side effects.

Storage

Ethyl cellulose is a secure, a little hygroscopic material. It is chemically resistant to water down as well as concentrated alkalis as well as salt options, although it is more sensitive to acids than cellulose esters.

Ethyl cellulose will undertake oxidative degradation under heat in the visibility of sunshine or ultraviolet light. This can be avoided by utilizing anti-oxidants as well as chemical ingredients that soak up light in the 230-340nm variety.

Ethyl cellulose need to be stored in a completely dry area with a temperature level not surpassing 32 ° C (90 ° F), away from all warmth sources. It should not be kept with peroxide or other oxidants.

References

  • Ethyl cellulose – WikiPedia
  • Mao Wenying, Zhang Shuosheng, Li Qiaoling. Application of ethylcellulose in traditional Chinese medicine preparations[J]. Shandong Chemical Industry, 2014, 43(2):2.

Ethyl Cellulose Supplier and Manufacturer

As a ethyl cellulose supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best ethyl cellulose raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for ethyl cellulose and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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