Diisopropyl Malonate CAS 13195-64-7

The invention belongs to the technical field of fine chemical product preparation, in particular to a preparation process of diisopropyl malonate.

The preparation process of diisopropyl malonate includes: Taking cyanoacetic acid as raw material, adding sulfuric acid for acidolysis to produce acidolysis solution; Isopropanol is added to the acidolysis solution for esterification. After the reaction, the solution is divided into upper solution and lower solution. Separate the upper layer solution, add isopropanol to the upper layer solution, carry out the secondary esterification reaction by reactive distillation, evaporate isopropanol after the reaction, neutralize and purify to obtain diisopropyl malonate; Isopropanol is added to the lower solution for extraction, in which the solution is layered twice, the upper solution is recycled as the first esterification reaction of the lower layer, and isopropanol is evaporated from the lower layer. Layer solution, and the evaporated isopropanol is used as the recycling material for the next esterification reaction. The invention avoids the problem of decomposing cyanoacetic acid in the later stage of the dehydration process, avoids the use of other organic solvents, and improves the product yield. Among them, the solution is divided into two layers, the upper solution is used as the recovery and reuse of the next esterification reaction, isopropanol is evaporated from the lower solution, and the evaporated isopropanol is used as the recovery and reuse material for the next esterification reaction. The invention avoids the problem of decomposing cyanoacetic acid in the later stage of the dehydration process, avoids the use of other organic solvents, and improves the product yield. Among them, the solution is divided into two layers, the upper solution is used as the recovery and reuse of the next esterification reaction, isopropanol is evaporated from the lower solution, and the evaporated isopropanol is used as the recovery and reuse material for the next esterification reaction.

The invention avoids the problem of decomposing cyanoacetic acid in the later stage of the dehydration process, avoids the use of other organic solvents, and improves the product yield. The distilled isopropanol is used as the raw material for the recovery and reuse of the next esterification reaction. The invention avoids the problem of decomposing cyanoacetic acid in the later stage of the dehydration process, avoids the use of other organic solvents, and improves the product yield. The distilled isopropanol is used as the raw material for the recovery and reuse of the next esterification reaction. The invention avoids the problem of decomposing cyanoacetic acid in the later stage of the dehydration process, avoids the use of other organic solvents, and improves the product yield.