Diethylenetriaminepentaacetic acid CAS 67-43-6 DTPA
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Diethylenetriaminepentaacetic acid supplement
Diethylenetriaminepentaacetic acid: The Complete Guide
Diethylenetriaminepentaacetic acid for Sale
Basic Info of Diethylenetriaminepentaacetic acid
Diethylenetriaminepentaacetic; DTPA diethylenetriaminepentaacetic acid; Pentetic acid
Organic Intermediates; Pharmaceutical Intermediates; Catalysts and Auxiliaries; Pharmaceutical raw materials; Organic raw materials
What is Diethylenetriaminepentaacetic acid?
Diethylenetriaminepentaacetic acid (DTPA), likewise called diethylenetriaminepentaacetic acid, is an outstanding ammonia carboxyl complexing agent with solid chelating properties. The equivalent chelate needs to be stable. As a high-efficiency chelating representative, it is used in color inhibitor in acrylic fiber production, paper sector, water conditioner, fabric auxiliary, chelating titrant, shade digital photography and also food market, and so on. At the same time, it additionally has a wide range of applications in clinical treatment, rare earth element separation and also agricultural manufacturing.
Pentetic acid or diethylenetriamine pentaacetic acid (DTPA) is an amino polycarboxylic acid, which is made up of diethylenetriamine primary chain with five carboxymethyl groups. This particle can be regarded as a prolonged variation of EDTA and also makes use of similar. It is a white solid with minimal solubility in water.
Diethylenetriaminepentaacetic acid Uses
As a high-efficiency chelating agent, diethylenetriaminepentaacetic acid can be made use of in shade prevention in acrylic fiber production, paper market, water conditioner, fabric accessory, chelating titrant, color digital photography and food market, and so on. It is also made use of in medical, rare earth components, and so on. It is additionally commonly utilized in separation and farming manufacturing.
- Diethylenetriaminepentaacetic acid is used in papermaking bleaching process as a hydrogen peroxide decomposition inhibitor.
- Chelating titrant. As a complexing agent drug, it is used for radioisotope and heavy metal poisoning treatment of actinide elements such as plutonium and americium.
- Diethylenetriaminepentaacetic acid is used as complexing agent, color flushing kit, decolorizing agent of acrylonitrile stock solution, etc.
- Diethylenetriaminepentaacetic acid is used as a reducing agent for aldehydes, ketones and acid chlorides, as a foaming agent for plastics, etc.
- As a color inhibitor for the production of acrylonitrile. It is also used in soaps as a water softener.
- Diethylenetriaminepentaacetic acid is the active ingredient in manganese and zinc fertilizers used in the agrochemical industry.
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Application of Diethylenetriaminepentaacetic acid
CN201410102702.0 discloses a preparation method and application of novel functionalized gold nanoparticles that can be visualized under magnetic resonance imaging technology.
In the present invention, diethylenetriaminepentaacetic acid with sulfhydryl group and polyethylene glycol with sulfhydryl group are used as modifiers, and the stable bonding action between Au-S bonds and a reducing agent are used to prepare functionalized gold nanoparticles. The ratio of gold nanoparticles to GdCl3 chelates Gd3+, and binds mPEG-SH, using the strong paramagnetism of Gd-DTPA complex and the hydrophilicity and bioaffinity of polyethylene glycol molecules, resulting in a small particle size. , uniform distribution, magnetic resonance imaging, long circulation, good biocompatibility of gold nanoparticles. The gold nanoparticles can be used for MRI in vivo tracking of the biodistribution and survival of the graft in the living host, and evaluation of the effect caused by the graft.
The invention provides a new way for the MRI in vivo tracing graft and the detection method of drug distribution in vivo.
Production Method of Diethylenetriaminepentaacetic acid
Put 283.7kg of monochloroacetic acid into the reactor, add 220L of distilled water and stir to dissolve. 40% NaOH solution, 300kg, was added dropwise at 15°C for about 1.5h. Then, 51.6 kg of diethylenetriamine was added dropwise with stirring, and the temperature was controlled at about 20°C during the dropwise addition. Then continue to add 120kg of NaOH aqueous solution (40%) dropwise. React at 40°C for 10-12h. The reaction solution was cooled to 5-10°C. Add 260L of concentrated hydrochloric acid dropwise with stirring, adjust the pH value to 1.6-1.7, stand overnight, filter out the crystals, wash the crystals with 400L of ice water, and vacuum dry to obtain a crude product of about 130kg. The pure product was obtained by decolorization with distilled water.