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Clindamycin Phosphate CAS 24729-96-2

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Clindamycin Phosphate Supplement
24729-96-2

Basic Info of Clindamycin Phosphate

What is Clindamycin Phosphate?

Clindamycin phosphate, trade name Cleocinphosphate, chemical name 6-(1-methyl-trans-1-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7( S)-Chloro-6,7,8-trideoxy-L-threo-α-D-galactopyranoside-2-dihydrogen phosphate, a semi-synthetic derivative of clindamycin, It rapidly hydrolyzes clindamycin in vivo and exhibits pharmacological activity.

Clindamycin phosphate is a chemical semi-synthetic derivative of clindamycin. It is a white or off-white crystalline powder at room temperature, odorless, bitter in taste and hygroscopic. It has no antibacterial activity in vitro, and can be rapidly hydrolyzed into clindamycin after entering the body to exert its pharmacological effect.

Its mechanism of action, antibacterial spectrum, indications, and therapeutic effects are the same as those of clindamycin, but its lipid solubility and permeability are better than those of clindamycin. It can be administered orally or intramuscularly and intravenously, mainly in the liver. Metabolized, excreted in bile and feces, partially excreted in urine. Compared with lincomycin, clindamycin phosphate has 4 to 8 times stronger antibacterial effect, good absorption, high bone tissue concentration, and strong antibacterial activity against Gram-positive cocci and anaerobic bacteria. Its antibacterial spectrum is: Gram-positive cocci include penicillin G-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus (except Streptococcus phosphate), Streptococcus pneumoniae, Micrococcus, etc.; Gram-positive bacilli include Clostridium spp. Bacillus, diphtheria, etc.; anaerobic bacteria include Clostridium, Bacteroides, Clostridium, Propionibacterium, Eubacterium, anaerobic coccus, etc.

Clinically, clindamycin phosphate is mainly used to treat tonsillitis, suppurative otitis media, sinusitis, acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess, bronchiectasis complicated infection and skin and soft tissue infection, such as furuncle, carbuncle , abscess, cellulitis, wound infection, burn infection, postoperative infection, etc., as well as acute urethritis, acute pyelonephritis, prostatitis, etc. of the urinary system, also used for osteomyelitis, sepsis, peritonitis, oral infection, etc.

Clindamycin Phosphate Uses

Clindamycin phosphate is hydrolyzed right into clindamycin with antibacterial activity after getting in the body. It has significant antibacterial effect, as well as has no cross-allergic response with penicillin as well as cephalosporin antibiotics. It can be utilized for those allergic to penicillin.

Clindamycin blocks protein synthesis by binding to 23S ribosomal subunits. Clindamycin has been proved to have neuromuscular blocking properties, which can enhance the effects of other neuromuscular blockers.

Clindamycin Phosphate Shot is a colorless or somewhat yellow clear liquid. Generally utilized for the complying with various contagious illness caused by Gram-positive germs:

  • Skin and soft cells infections: boils, carbuncles, abscesses, cellulitis, wounds, burns and also post-operative infections.
  • Urinary system infection: severe urethritis, acute pyelonephritis, prostatitis, and so on
  • Others: osteomyelitis, blood poisoning, peritonitis as well as oral infection.

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Synthesis of Clindamycin Phosphate

The synthesis scheme of choline phosphate clindamycin is shown in the figure. The synthesis of CH CP is as follows. Weigh clindamycin phosphate (1.00 g, 1.98 mmol), add 10 ml of distilled water, and stir until transparent. Then gradually add choline (48-50% aqueous solution, 0.96g, 3.96mmol). Under closed conditions, the reactant solution was stirred at 25 ℃ for 24 hours, and then concentrated at 40 ℃. After vacuum drying at 35 ℃ overnight, a yellowish viscous choline phosphate clindamycin liquid was obtained with a yield of 1.06 g (75.4%). 

Reference

  1. Clindamycin phosphate – PubChem
  2. “Synthesis  of  a  chiral  ionic  liquid,  cholinium-clindamycin  phosphate,”.

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