Calcium Gluconate CAS 299-28-5
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Calcium Gluconate Supplement
Calcium Gluconate: The Complete Guide
Index of Calcium Gluconate Contents
Calcium Gluconate for Sale
Basic Info of Calcium Gluconate
calcium gluconate iv; ca gluconate; calcium gluconate bnf; calcium gluconate medscape; calcium d gluconate
Food additives; Pharmaceutical raw materials; Plant extracts; intermediates for pharmaceuticals, pesticides, dyes
What is Calcium Gluconate?
Calcium gluconate (calcium gluconate) is the calcium salt of gluconic acid, the molecular formula is C12H22CaO14 H2O, the molecular weight is 448.40, the melting point is 201 ° C, it is a white crystal or powder, odorless and tasteless, soluble in cold water, easily soluble in hot water , Insoluble in absolute ethanol, chloroform or ether. Calcium gluconate is an important organic calcium. It is clinically used as a calcium supplement and a raw material for the production of other gluconates (zinc gluconate, iron gluconate, etc.) and glucono delta-lactone. It is an important chemical industry in my country. export product. Calcium gluconate is mainly used as calcium fortifier and nutrient, buffer, solidifying agent and chelating agent in food. Glucose and calcium carbonate were mixed together, glucose oxidase and catalase were added, and calcium gluconate was directly obtained by oxidation at 37°C.
Calcium gluconate is a mineral supplement and drug. As a drug, it is administered intravenously to treat hypocalcemia, hyperkalemia and magnesium poisoning intravenously. Supplements are usually needed only when calcium is insufficient in the diet. Supplementation can treat or prevent osteoporosis or rickets. It can also be taken orally, but injection into muscle is not recommended.
Side effects during injection include decreased heart rate, pain at the injection site and hypotension. Side effects of oral administration may include constipation and nausea. The blood calcium level should be measured when using, and those with a history of kidney stones should be extra careful . At normal doses, it is considered safe to use during pregnancy and lactation.
Calcium Gluconate Uses
- Calcium gluconate is an important organic calcium. It is mainly used as a calcium fortifier and nutrient, buffer, solidifying agent and chelating agent for food, and has a very broad application prospect.
- As a drug, calcium gluconate can reduce capillary permeability, increase density, maintain normal excitability of nerves and muscles, enhance myocardial contractility, and help bone formation.
- Calcium gluconate is indicated for allergic conditions such as urticaria; eczema; pruritus; contact dermatitis, and serum sickness; angioedema as adjunctive therapy. It is also used for the prevention and treatment of calcium deficiency.
- As a food calcium fortifier, calcium gluconate has better absorption effect than inorganic calcium. my country stipulates that it can be used in cereals and their products, and the dosage is 18-36g/kg; in milk beverages and drinking liquids, it is 4.5-9.0g/kg.
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Medical Use of Calcium Gluconate
10% calcium gluconate solution (intravenous administration) is the most widely used calcium agent in the treatment of hypocalcemia. This form of calcium is not absorbed like calcium lactate. It contains only 0.93% (930 mg / dl) calcium ions (defined as 1 g by weight of solute in 100 ml solution to make 1% solution w / V). Therefore, if hypocalcemia is acute and severe, calcium chloride should be given instead.
Calcium gluconate is used as a cardioprotective agent in people with high blood potassium levels. An alternative is to use calcium chloride. It is recommended when the potassium level is high (> 6.5 mmol / L) or the electrocardiogram (ECG) shows changes due to hyperkalemia.
Although it has no effect on the level of potassium in the blood, it can reduce the excitability of cardiomyocytes and reduce the possibility of arrhythmia.
- Magnesium sulfate excess
It is also used to counteract excess Epsom magnesium sulfate, which is usually used in pregnant women to prevent seizures (such as patients with preeclampsia). Magnesium sulfate is no longer given to pregnant women undergoing preterm birth to slow or stop uterine contractions (due to better efficacy and side effects, other uterine contractions are now used instead). [need to quote] excessive magnesium sulfate can lead to magnesium sulfate poisoning, resulting in respiratory depression and loss of deep tendon reflex (hyporeflexia).
- Hydrofluoric acid burn
Calcium gluconate gel is used to treat hydrofluoric acid burns. Calcium gluconate reacts with hydrofluoric acid to form insoluble and non-toxic calcium fluoride. In addition to using 2.5% calcium gluconate gel directly for chemical burns, patients may also receive calcium gluconate supplements because fluoride ions precipitate serum calcium, resulting in hypocalcemia.
- Cardiac arrest
Although intravenous calcium has been used for cardiac arrest, it is not recommended for general use. Still recommended cases of cardiac arrest include hyperkalemia, hypocalcemia (e.g. that may occur after blood transfusion) and excess calcium channel blockers. General use may worsen the results. If calcium is used, calcium chloride is usually the recommended form.
Preparation of Calcium Gluconate
- Neutralization reaction
Add gluconolactone to the batching tank, and at the same time add pure water or condensed water, so that the mass fraction of the gluconolactone solution is 15-22%, and the prepared gluconolactone solution is pumped into the neutralization barrel, Carry out stirring, slowly add CaCO3 or Ca(OH)2 in the stirring process, open the steam valve of the neutralization tank, use the jacket of the neutralization tank to slowly heat up, control the temperature to be 80-85 ℃, keep the temperature for 20-30 minutes, The pH is 6.5-7.5 to obtain calcium gluconate solution;
- Decolorization and filtration
After the neutralization reaction is completed, add activated carbon to the neutralization barrel in an amount of 0.3-0.5% (mass fraction), stir, the rotating speed is 25-35 rpm, the temperature is 80-85 ° C, and the decolorization is 30-40 minutes. , to obtain calcium gluconate solution; add perlite, diatomite and water to the pre-coating tank for ingredients, the mass ratio of perlite, diatomite and water is 40:20:1000, stir for 10 minutes to obtain a pre-coating solution , use the precoating pump to drive the precoating liquid into the plate and frame filter press at a pressure of 0.2MPa to precoat the filter cloth. After the coating is completed, turn on the material pump to drive the neutralized and decolorized calcium gluconate solution into the plate and frame pressure. Filtration is carried out in the filter, the filtration pressure is 0.5MPa, and the plate and frame filtrate is obtained after filtration. When the transmittance is ≥99%, the plate and frame filtrate is injected into a precision filter with a precision of 0.1-0.5um; When the luminosity is less than 99%, return the plate and frame filtrate to the neutralization bucket, and return the pre-coating solution to the pre-coating tank; the plate and frame filtrate is filtered by the precision filter and then poured into the decolorizing solution storage tank;
- Spray drying
Use a high-pressure screw pump to pump the calcium gluconate solution in the decolorizing liquid storage tank into the spray drying tower of the spray drying device for spray drying. During the spraying process, control the feeding pressure of the screw pump to be 0.3-0.6MPa; the air inlet of the spray drying tower The temperature is 150-180℃, and the air outlet temperature is 75-85℃; the moisture content of calcium gluconate after drying is ≤0.5%;
- Packaging process
The dried calcium gluconate is separated by a cyclone and then enters the silo, and then goes through an automatic packaging line for finished product packaging.
- “Calcium gluconate Use During Pregnancy | Drugs.com”. www.drugs.com. Archived from the original on 18 January 2017. Retrieved 15 January 2017.
- British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 680, 694. ISBN 9780857111562.
- “Calcium Salts”. The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.