Bisoprolol Fumarate CAS 104344-23-2
Factory Supply Bisoprolol Fumarate CAS 104344-23-2 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Bisoprolol Fumarate Supplier & Manufacturer
Bisoprolol Fumarate: The Complete Guide
Bisoprolol Fumarate for Sale
|Chemical Name:||Bisoprolol Fumarate|
|Other Name:||Bisoprolol heMifuMarate salt; OBAT Bisoprolol fumarate|
|Type:||Pharmaceutical raw materials; Intermediates of pharmaceuticals, pesticides, dyes; Daily chemicals|
What is Bisoprolol Fumarate?
Hypertension and angina pectoris are the most common cardiovascular diseases in the world today and the leading causes of death and disability in adults. In recent years, with the progress of society, the improvement of people’s living standards and the continuous acceleration of the pace of work, the number of patients with hypertension has increased significantly. The prevalence rate of hypertension and angina pectoris has also increased significantly in my country, and China has become one of the countries with the most serious harm of these two diseases in the world. Hypertension can cause damage to the heart, brain, kidney and other organs, seriously threatening human health and life.
Bisoprolol fumarate is a P1 receptor blocker with high cardioselectivity. Within the therapeutic dose range, this product has no obvious membrane stabilizing effect or intrinsic sympathomimetic effect. The effect time is long, the symptoms are well controlled by continuous administration and there is no tolerance phenomenon, the side effects on the respiratory system are minimal, and there is no effect on fat catabolism. Clinically, bisoprolol fumarate is used for the treatment of essential hypertension and angina pectoris.
Bisoprolol Fumarate Uses
- Highly selective β1 receptor blocker, better antihypertensive effect and better prognosis.
- Water-fat dual-dissolution: better pharmacokinetic properties (once a day).
- Liver-kidney dual-channel metabolism, safe, stable, long-acting and long-lasting.
- National Basic Drug List and Medical Insurance List.
- Basic drugs for the prevention and treatment of hypertension, coronary heart disease and chronic heart failure.
- This product should be used for a long time to protect the heart, prevent and treat ischemic heart disease, chronic heart failure, and reduce mortality and hospitalization.
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Antihypertensive drugs mainly exert their antihypertensive effect by affecting the sympathetic nervous system, renin-angiotensin-aldosterone system and endothelin system, which play an important role in the physiological regulation of blood pressure.
β-receptor blockers are a class of adrenoceptor blocker antihypertensive drugs commonly used in clinical practice. They have always played an important role in the treatment of cardiovascular diseases. Excessive activation improves myocardial function, slows heart rate, and effectively lowers blood pressure.
According to the selectivity to β1 and β2 receptors and whether it has α receptor blocking effect, it can be mainly divided into:
- Non-selective β1 and β2 receptor blockers
- Selective β1 receptor blockers
- α, β receptor blockers
Bisoprolol fumarate is a highly selective long-acting β1 receptor blocker, which has the effects of slowing heart rate, lowering blood pressure, reducing cardiac afterload, and reducing myocardial oxygen consumption. Bisoprolol has a protective effect on the myocardium, can block the ventricular hypertrophy caused by the adrenergic system, reverse the decrease in left ventricular compliance, thereby improving ventricular remodeling and preventing the occurrence of heart failure.
Bisoprolol fumarate has high β1-receptor selectivity, which can safely lower blood pressure and protect the heart from heart failure. Effective treatment of essential hypertension. It does not affect sugar and lipid metabolism. No significant membrane stabilizing or intrinsic sympathomimetic effects were observed in the therapeutic dose range. High doses (≥20 mg) can inhibit β2 adrenergic receptors (β2 receptors are mainly located in bronchial and vascular smooth muscle). The selectivity to β1 receptor is 4 times that of atenolol.
High bioavailability, the absolute bioavailability after dental administration of 10mg has to do with 80%, as well as its absorption is not impacted by food. Liver initially pass metabolic process has to do with 20%. Lengthy half-life, 9-12 hours. It is a little lengthened in elderly people, partially related to the decrease of kidney feature in these people. The average optimal plasma concentration variety is 16ng/m-l 70ng/ml. Management once daily, long-lasting stable blood pressure decrease. It is gotten rid of from the body with both liver and also kidney pathways.
Keep in mind: β receptors include β1 as well as β2 receptors, and β1 receptors are primarily dispersed in the heart, which can increase myocardial contractility, self-discipline and also transmission function. β2 receptors are primarily dispersed in bronchial smooth muscle mass, vascular smooth muscle as well as heart muscle, and so on, as well as moderate bronchial smooth muscle mass relaxation and vasodilation.
- Bisoprolol fumarate – PubChem
- Wang Bin. Observation on the effect of bisoprolol fumarate in the treatment of hypertension[J]. Contemporary Medicine, 2017,15(07):61-62.
Bisoprolol Fumarate Supplier and Manufacturer
As a bisoprolol fumarate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best bisoprolol fumarate raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for bisoprolol fumarate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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