Best Arbutin CAS 497-76-7 Beta-Arbutin

1. Liposomes: Several arbutin liposomes were prepared by membrane dispersion method. Compared with the solution formulation, although the permeability of arbutin liposomes was decreased, its deposition rate in the epidermis/dermis layer was increased.
2. Film coating agent: The compound arbutin emulsion film is prepared by using the emulsion preparation method, using the polymer polyvinyl alcohol as the film-forming material, and adding azone as the penetrant, which is used for the treatment of clinical chloasma. The results show that the preparation has stable properties, is smooth and easy to coat, and has excellent film-forming and releasing properties. Some people also use the same film-forming material, add arbutin and traditional Chinese medicine extract to make a film coating agent, which is clinically used to treat chloasma, with a total effective rate of 96.9%, and no adverse reactions were found.
3. Cream: “Scheff” compound cream contains all-trans retinoic acid, arbutin and vitamin E for the treatment of chloasma. Clinical observation showed that the total effective rate was 77.6% in the treatment group and 26.5% in the control group. Using 3.5%-4% arbutin and several traditional Chinese medicines (Angelica Radix, Astragalus, etc.) to make freckle cream for the treatment of chloasma, the total effective rate in clinical observation was 83.0%, and there was no adverse reaction in any case.
4. Cosmetics: Many countries in the world have applied arbutin to cosmetics to achieve a whitening effect. Such as Japan’s internationally renowned brand Shiseido and so on. There are also many cosmetics in China that add arbutin, such as Dingjiayi brand cosmetics.

Some people extract active ingredients from bilberry to treat acute and chronic bronchitis, and make five new types of traditional Chinese medicines, of which the main active ingredient is arbutin.

Azelaic acid, kojic acid and its derivatives, hydroquinone, etc. inhibit tyrosinase activity and reduce melanin production through competitive and/or non-competitive mechanisms; vitamin C and its derivatives, α-lipoic acid, α-tocopherol Phenol, etc. interfere with melanin synthesis through antioxidant effects; tretinoin prevents the transport of melanin to keratinocytes, resulting in hypopigmentation; unsaturated fatty acids can stimulate cell renewal and promote the shedding of keratinocytes containing melanin granules, resulting in Decolorization; some traditional Chinese medicine monomers or prescriptions play the role of decolorizing agents through different ways.

Among them, VitC injection and hydroquinone have the highest inhibition rate on tyrosinase activity, and the lowest concentration of half inhibition, so the whitening effect is the best. However, in practical applications, due to the strong cytotoxicity of hydroquinone, it will cause permanent depigmentation of the skin, which has been gradually eliminated. The whitening effect of VitC has a great relationship with its own structure and state. Usually, only levorotatory VitC has a whitening effect. VitC is water-soluble, not easy to penetrate into the stratum corneum of the skin, and is easily oxidized and unstable, so its application is limited. It is usually combined with metals such as sodium and calcium to maintain its stability, or used in cosmetics in the form of VitC derivatives. Arbutin has good whitening effect, relatively small cytotoxicity and stable properties, so it is the most widely used whitening agent at present.