
Best Vitamin D3 CAS 67-97-0




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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Best Vitamin D3 Supplier & Manufacturer
Best Vitamin D3 for Sale
Basic Info of Best Vitamin D3
Chemical Name: | Best Vitamin D3 |
Other Name: | Vitamin D3; 9,10-Ring-opened Cholesta-5,7,10(19)-trien-3beta-ol; Cholecalciferol; Activated 7-Dehydrocholesterol; Vitamin D3; Vitamin D3 Crystal |
CAS: | 67-97-0 |
EINECS: | 200-673-2 |
Type: | Food and feed additives; APIs |
Molecular Formula: | C27H44O |
Molecular Weight: | 384.64 |
Melting point | 83-86 °C(lit.) |
Alpha | 105 º (c=0.8, EtOH 25 ºC) |
Boiling point | 451.27°C (rough estimate) |
Density | 0.9717 (rough estimate) |
Vapor pressure | 2.0 x l0-6 Pa (20 °C, est.) |
Refractive index | 1.5100 (estimate) |
Fp | 14 °C |
Storage temp. | -20°C |
Solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds. |
Form | powder |
Pka | 14.74±0.20(Predicted) |
Water Solubility | <0.1 g/L (20 ºC) |
Sensitive | Air & Light Sensitive |
Brand Name: | Zhishang Chemical |
Provide: | Best Vitamin D3 MSDS; Best Vitamin D3 COA |
What is Best Vitamin D3?
Vitamin D3, also known as cholecalciferol, is a type of vitamin D that has been shown to be the true active form of vitamin D in the body. There are at least 10 known types of vitamin D, but the most important are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol).
Vitamin D plays an important role in maintaining stable blood calcium and phosphorus levels and is required for normal bone mineralization processes, muscle contraction, nerve conduction, and basic cellular functions.
Vitamin D is involved in the transcription of calcium transporters and bone matrix proteins and the regulation of cyclin transcription, increasing the differentiation of specialized cells in the body. This property of vitamin D may explain its role in bone resorption, calcium transport in the intestinal lumen, and in the skin.
Long-term vitamin D deficiency is associated with rickets in children and osteomalacia in adults. Vitamin D deficiency remains a worldwide problem, especially among those living in high latitudes or those with less skin exposure to sunlight.
Best Vitamin D3 Uses
Vitamin D deficiency affects nearly 50% of the world’s population. Vitamin D2 and D3 can be used to treat this disease, and vitamin D3 is usually the first choice.
In addition to the treatment of vitamin D deficiency, vitamin D3 can also bring health benefits to some people without such deficiency.
Hypertension, commonly known as hypertension, is a common cardiovascular disease in patients with vitamin D deficiency.
Recent studies have shown that vitamin D3 may help reduce blood pressure in people with hypertension and vitamin D deficiency, as well as in some people with hypertension only.
According to the review of a study involving 1687 people published in the Journal of Medicine in 2019, vitamin D3 can significantly reduce the systolic blood pressure (upper) of people over 50 years old and obese people.
This is important because over time, simple systolic hypertension will increase the risk of stroke, heart disease and chronic kidney disease.
Osteoporosis is a common consequence of long-term vitamin D deficiency. Common sense suggests that vitamin D supplements may help prevent (or slow down) this common age-related bone disease. There is some evidence to support this claim.
A study conducted by the University of Western Australia in 2013 found that vitamin D3 can significantly reduce the incidence of hip fracture in nursing home residents aged 70 and above. In addition, low-dose vitamin D3 (400 IU) also increased bone density of femur (thigh).
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Why Choose Vitamin D3?
When a person cannot get enough vitamin D from food or sunlight, he can use vitamin D supplements. There are two forms – vitamin D2 and vitamin D3 – each of which has its advantages and disadvantages.
Vitamin D2 and vitamin D3 have similar chemical properties and can be well absorbed by the intestine. Their significant difference lies in their source:
Vitamin D2 is naturally found in mushrooms, including lentinus edodes, Puerto bello mushrooms and black mushrooms. When these mushrooms are exposed to ultraviolet radiation, the content of vitamin D will increase.
Vitamin D3 is naturally present in animals and animal-derived products (such as milk). When the skin is exposed to ultraviolet B (UVB) radiation, it will also be directly synthesized in the skin.
Another difference between vitamin D3 and vitamin D2 lies in its bioavailability (the proportion of drugs entering the blood) and half-life (a measure of the retention time of drugs in the circulation).
Others
The bones are in a dynamic balance every day. Around the age of 35, the mineral density of the bone reaches the peak, that is, the peak bone mass, and then the bone mass gradually decreases with age. The lower level, according to the statistics of Chinese men and women over 50 years old with low bone mass, reached 57.6% and 64.6% respectively, which means that a large number of middle-aged and elderly people are at risk of osteoporosis.
As a hidden disease, osteoporosis often has a long accumulation period. At this stage, the bone strength will become lower and lower. For example, middle-aged and elderly people often suffer from waist and leg pain, cramps, muscle weakness, etc. Unsteady standing and easy falling are all signs of osteoporosis and should be paid attention to in time. Although many middle-aged and elderly people have healthy living habits and actively come to the sun to bask in the sun, it is difficult for the middle-aged and elderly people to synthesize enough vitamin D even if they are exposed to a lot of sunlight due to the reduced ability of their skin to synthesize vitamin D and supplement additional vitamins. D nutrients are essential.
Osteoporotic fractures are the most serious complication of osteoporosis. Unlike other fractures, osteoporotic fractures refer to fractures that occur with minor trauma or during daily activities, i.e. minor forces that do not usually cause the fracture resulting fractures. The lifetime incidence of osteoporotic fractures in men is 13% higher than in prostate cancer, and in women it is 40% higher than in breast, endometrial and ovarian cancers combined.
In daily life, it is also necessary to pay attention to increasing anti-skid and anti-fall measures, increasing the number of handrails in the room, and adding anti-skid pads to areas such as bathrooms and kitchens to reduce the incidence of falls. Because vitamin D can effectively increase muscle strength and coordination, Thereby reducing the risk of falling, so vitamin D supplementation also needs to be carried out at the same time.
The answer is yes, vitamin D is not only a preventive measure for osteoporosis, but also a treatment measure for osteoporosis. Patients with osteoporosis are in a state of deficiency of vitamin D and calcium, and they need to be actively supplemented. While taking anti-osteoporosis drugs, taking vitamin D can maintain the balance of bone calcium and blood calcium, and protect vitamin D to activate the metabolic system.
Of course, vitamin D supplementation is a long-term process. Many people stop taking the vitamin D after taking the amount for a few days or weeks every day and find that the effect is not good. This is absolutely not advisable. Adhere to supplementation, in order to completely avoid osteoporosis. The “Guidelines for the diagnosis and treatment of primary osteoporosis (2017 edition)” also recommends that 800-1200 IU of vitamin D should be supplemented every day for the prevention and treatment of osteoporosis.
The bone health of middle-aged and elderly people is more inseparable from vitamin D.
The easiest way to improve immunity is to eat scientifically and live a healthy life. Having a good living habit is very important to improve immunity, living a healthy life and having a balanced diet can maintain the best physical condition. Actively participate in outdoor activities, exercise to enhance physical fitness, and focus on the intake of vitamins and proteins in food.
In order to promote the synthesis of vitamin D, it is also necessary to strengthen the full sun exposure in life. When indoors, it is also important to maintain room hygiene, ventilation, and vitamin D supplementation.
It is well known that the role of vitamin D is to promote intestinal calcium and phosphorus absorption and bone calcification, and maintain the balance of blood calcium and blood phosphorus. So what does it have to do with our immune function? Studies have pointed out that the strength of human immune function is related to vitamin D levels. When the concentration of vitamin D in human blood is high, it can promote the differentiation of monocytes into mature macrophages, so that the immune function is also at a high level. (“Progress in Research on the Relationship between Vitamin D and Immune Regulation and Human Diseases”)
At the same time, some studies have found that in people with vitamin D deficiency (25(OH)D<25nmol/L), vitamin D supplementation has a more significant protective effect on respiratory infections, and daily or weekly supplementation is more significant than occasional supplementation Sexual high-dose supplementation is better. This analysis revealed from the side that vitamin D has a role in regulating the immune function of the body, especially for people with vitamin D deficiency, the effect will be better. (“Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data”)
For children and adolescents, vitamin D should be supplemented with 400-800 IU daily; for pregnant and lactating women with severe vitamin D deficiency, the “Consensus on the Clinical Should of Vitamin D and Its Analogues (2018 Edition)” recommends vitamin D supplementation of 1500-2000 IU /d; For middle-aged and elderly people, daily supplementation of vitamin D800-1200 IU is not only beneficial to bone health, but also to a certain extent, it is beneficial to improve immunity and help resist diseases.
Reference
The Health Benefits of Vitamin D3. A type of vitamin D sourced from animal-based foods and sunlight. By Yvelette Stines
Best Vitamin D3 Supplier and Manufacturer
As a Vitamin D3 supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Vitamin D3 raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for Vitamin D3 and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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