Model No.: CAS NO 88-65-3
Status: Liquid Catalyst
Response Type: Polymerization
Classification: Homogeneous Catalysts
Usage: Negative Catalyst
Effect Size: Promoter Catalysts
Manufacturing Method: Mechanical Mixing
Application Industry: Physiology
Name:: 2-Bromobenzoic Acid
Density:: 1,929 G/cm3
Melting Point:: 147-150 °C(lit.)
Boiling Point:: 296.4ºC At 760 MmHg
Packaging: in 25kg drum
Productivity: 10000kg per month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 88-65-3
Best selling 2-Bromobenzoic acid CAS 88-65-3
2-Bromobenzoic acid is a sterically hindered ortho-bromo compound that is used as a starting material to synthesize quinazolinones (e.g. 8-Hydroxy-2-methyl-4(3H)-quinazolinone [H948330]).
1. Add phenol to the reaction kettle, stir and add water and heat up to 60°C. Add bromine dropwise. Continue stirring for 30 minutes after the addition is complete. Then it was cooled to 40°C and filtered. The cake was washed with water until neutral to obtain crude product. The crude product was dissolved in ethanol at 70° C., activated carbon was added for decoloration, and after filtering, an equal amount of water was mixed with the filtrate, ie, needle-like crystals were precipitated as a finished product. The yield is about 96%.production methodproduction method
0.8 L of water and 210 g (1.5 mol) of powdered anthranilic acid were added to the beaker and stirred into a paste. While stirring, slowly add 90ml (160g, 1.6mol) of concentrated sulfuric acid and 100mL of cold dilute sulphuric acid (this avoids caking), externally cool and stir for 10min. Slowly add 105g (1.5mol) of NaNO2 dissolved in 150mL of water to a cold solution at 5-12°C. After addition, the volume is approximately 1.4L, which is basically clear; add 5g of urea and stir for 10min to decompose excess nitrous acid (if necessary, add 1 mL of octanol to eliminate the foam) and let it stand for 10 min to allow a few non-diazotized anthranilates to settle (for longer periods of time and cooling, crystalline sodium sulfate will precipitate). The diazonium salt solution was added in portions to a solution of cuprous bromide at about 80°C. A 5L beaker was charged with 240 g (1.65 mol) cuprous bromide dissolved in 600 mL 42% hydrobromic acid (4.4 mol) and the reaction heated to 80°C with stirring. After cooling to 60°C, the solution was filtered off (the mother liquor was retained), and the mother liquor of the cuprous chloride was eluted with 150 mL of hot water. The mother liquor was retained and washed with hot water until the blue color of the copper salt was almost completely eliminated. The wet product was stirred with 1.2 L of hot water, neutralized with 40% NaOH (the reaction was gray-green to yellow brown, pH 9-10), heated to 80 DEG C, filtered, and the filtrate was dark gray; Heat to 80°C, slowly add 20g of KMnO4 dissolved hot concentrated solution under stirring, filter out MnO2 and rinse it twice with warm water. The brownish yellow filtrate and washings are combined and heated to 90°C and acidified with hydrochloric acid to maintain 90°C. , Stir for 10 min, cool to 60°C, filter it out, and wash it thoroughly with hot water of about 60°C until the washing liquid is only very light yellow, and 400 g of dark yellow wet product is obtained. 245 g of product after drying, melting point 146.5 to 147.6°C. Refining: The above 245g crude product is dissolved in 270mL hot acetic acid (1:1
.1) Decolorize and filter, cool to 20°C (agitate a few times to avoid agglomeration after starting crystallization), filter it out, and dip it once with a little acetic acid to obtain 220g (wet) appearance brownish yellow product; dissolve, precipitate and wash as above Once, air dried to yield 175 g of product.
For organic synthesis.
Q1. Are you a manufacturer
Answer: Yes, we have our own factory called [ZhiShang Industry Group “, we export by ShandongZhishangchemical Co., Ltd.
Q2. Do you have GMP or DMF
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment
Answer: Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well
Q5. When will you deliver the goods
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.
You also can choose your own shipping forwarder.
Q7. When will we receive the goods
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.
2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period, it can not be taken directly by patients.
3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.