Model No.: X-CAS 303-49-1
Boiling Point:: 434.2°C At 760 MmHg
EINECS No.:: 206-144-2
Type:: Central Nervous System Agents
Flash Point:: 216.4°C
Refractive Index:: 1.581
Packaging: 25kg/drum according to customer’s requiement
Productivity: 1000kg per Month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 303-49-1
API Clomipramine CAS NO 303-49-1
Chlormopramine is a safe and reliable, rapid onset of tricyclic antidepressants, at room temperature for the white or slightly yellow crystalline powder; odorless, bitter; case of light color gradient yellow. In glacial acetic acid or chloroform easily soluble in water or ethanol soluble, slightly soluble in acetone, almost insoluble in ether. By inhibiting the presynaptic membrane of norepinephrine (NA) and serotonin (5-HT) reuptake and produce antidepressant effect, as well as anti-anxiety and sedation. Inhibition of serotonin reuptake effect is stronger than other tricyclic drugs, inhibition of norepinephrine reuptake effect is less than imipramine and amitriptyline, its anticholinergic role in moderate, sedative effect is low. Oral absorption is good, the treatment of plasma concentration of 200 ~ 500ng / ml, 1 to 2 weeks to reach steady-state blood concentration.
The liver metabolism, active metabolites demethamphetamine concentration is the original drug concentration of 2 times. Plasma protein binding rate of 96 ~ 97%, half-life of 21 to 31 hours. About 70% from the urine, 30% from the feces. Suitable for the treatment of endogenous, reactive, neurological, occult depression and a variety of depression; accompanied by depression schizophrenia; obsessive-compulsive disorder, phobia; The drug also reduces the level of 5-hydroxyindoleacetic acid (5HIAA) in cerebrospinal fluid and platelets, which is associated with the treatment of obsessive-compulsive disorder and has an affinity for D2 receptors, alpha adrenergic receptors and histamine receptors. In addition, there is a strong anti-cholinergic effect, and with mild antagonism of dopamine can increase plasma prolactin and growth hormone levels.
Appearance:White crystalline powder
White crystalline powder, slightly hygroscopic;
Freely soluble in water and in methylene chloride, soluble in alcohol
B. IR spectrum is in concordance with the reference one
E. yields reaction characteristics of chloride
Appearance of solution
Solution S: clear & not more intensely colored than the reference solution Y5
3.5 ~ 5.0
Impurity B: NMT 0.1%
Impurity C, D: each NMT 0.2%
Impurity F: NMT 0.1%
Any other impurity: NMT 0.1%
Total of other impurities: NMT 0.2%
Total of impurities: NMT 1.0%
Loss on drying
Assay (dried substances)
99.0% ~ 101.0%
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.
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3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.
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