API Clomipramine CAS NO 303-49-1

Basic Info

Model No.: X-CAS 303-49-1

Appearance:: White

MF:: C19H23ClN2

Boiling Point:: 434.2°C At 760 MmHg

Purity:: 99%

EINECS No.:: 206-144-2

Type:: Central Nervous System Agents

Density:: 1.119g/cm3

Flash Point:: 216.4°C

Refractive Index:: 1.581

MW: 1.581

Additional Info

Packaging: 25kg/drum according to customer’s requiement

Productivity: 1000kg per Month

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

HS Code:  303-49-1

Port: Shanghai,Qingdao,Tianjing

Product Description

API Clomipramine CAS NO 303-49-1


Chlormopramine is a safe and reliable, rapid onset of tricyclic antidepressants, at room temperature for the white or slightly yellow crystalline powder; odorless, bitter; case of light color gradient yellow. In glacial acetic acid or chloroform easily soluble in water or ethanol soluble, slightly soluble in acetone, almost insoluble in ether. By inhibiting the presynaptic membrane of norepinephrine (NA) and serotonin (5-HT) reuptake and produce antidepressant effect, as well as anti-anxiety and sedation. Inhibition of serotonin reuptake effect is stronger than other tricyclic drugs, inhibition of norepinephrine reuptake effect is less than imipramine and amitriptyline, its anticholinergic role in moderate, sedative effect is low. Oral absorption is good, the treatment of plasma concentration of 200 ~ 500ng / ml, 1 to 2 weeks to reach steady-state blood concentration. 

The liver metabolism, active metabolites demethamphetamine concentration is the original drug concentration of 2 times. Plasma protein binding rate of 96 ~ 97%, half-life of 21 to 31 hours. About 70% from the urine, 30% from the feces. Suitable for the treatment of endogenous, reactive, neurological, occult depression and a variety of depression; accompanied by depression schizophrenia; obsessive-compulsive disorder, phobia; The drug also reduces the level of 5-hydroxyindoleacetic acid (5HIAA) in cerebrospinal fluid and platelets, which is associated with the treatment of obsessive-compulsive disorder and has an affinity for D2 receptors, alpha adrenergic receptors and histamine receptors. In addition, there is a strong anti-cholinergic effect, and with mild antagonism of dopamine can increase plasma prolactin and growth hormone levels.

 Appearance:White crystalline powder


White crystalline powder, slightly hygroscopic;

Freely soluble in water and in methylene chloride, soluble in alcohol


B. IR spectrum is in concordance with the reference one


E. yields reaction characteristics of chloride

Appearance of solution

Solution S: clear & not more intensely colored than the reference solution Y5


3.5 ~ 5.0

Related substances

Impurity B: NMT 0.1%


Impurity C, D: each NMT 0.2%


Impurity F: NMT 0.1%


Any other impurity: NMT 0.1%


Total of other impurities: NMT 0.2%


Total of impurities: NMT 1.0%

Heavy Metals

NMT 20ppm

Loss on drying

NMT 0.5%

Sulfated ash

NMT 0.1%

Assay (dried substances)

99.0% ~ 101.0%

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period uut it can not be taken directly by patients.

3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.

Why Choose Us?                                                                    


1. Quality Price

We are the manufacturer, so we can provide the competitive price and high quality product.

2. Packing

Products could be packaged according to customer’s specializedrequirements.

3. Transport

The products can be transported by Courier, by Air or by Sea.

4. Service

We offer specialized logistic service including export declaration,customs clearance and every detail during shipment. This makes us able to offer you one-stop service from the order to the products transported to your hand.

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