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Acetobromo-α-D-glucuronic acid methyl ester CAS 21085-72-3

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Acetobromo-α-D-glucuronic acid methyl ester Supplement
21085-72-3

Basic Info of Acetobromo-α-D-glucuronic acid methyl ester

What is Acetobromo-α-D-glucuronic acid methyl ester?

Alpha-D-glucuronic acid methyl ester, also known as acetyl bromide-α-D-glucuronic acid methyl ester, can be prepared from D-glucuronic acid methyl ester by using D-glucuronide as raw material, and then acetylated. Obtain 1,2,3,4-tetra-O-acetyl-D-glucuronic acid methyl ester, and finally brominate to obtain A-D-glucuronic acid methyl ester.

Acetobromo-α-D-glucuronic acid methyl ester Uses

  1. Acetobromo-α-D-glucuronic acid methyl ester was used to synthesize hmr1098-s-methyl glucuronate, which is a new K-ATP blocker and can be used as a drug to prevent sudden cardiac death.
  2. Acetobromo-α-D-glucuronic acid methyl ester (cas 21085-72-3) is a useful compound, which can be used to prepare fluorescent probes for human heparanase.
  3. Acetobromo-α-D-glucuronic acid methyl ester is used to synthesize camptothecin water-soluble glucosidic acid derivatives for cancer prodrug monotherapy and antibody directed enzyme prodrug therapy (ADEPT).
  4. Acetyl bromide- α- Methyl D-glucuronate is used to synthesize the glucuronic acid prodrug compound of tofatinib, a Janus kinase (JAK) inhibitor, which can be β- The cleavage of glucuronidases, such as those produced by the gastrointestinal microbiome, increases the level of tofatinib at the site of gastrointestinal inflammation and limits the systemic exposure of tofatinib in the treatment of local inflammatory diseases.

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Preparation of Acetobromo-α-D-glucuronic acid methyl ester

Reference

  1. Acetobromo-alpha-D-glucuronic acid methyl ester – PubChem
  2. CN201810068438.1 Substrate for detecting β-D-glucuronidase and preparation method and kit thereof

Quality Control of Acetobromo-α-D-glucuronic acid methyl ester

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