5-Aminolevulinic Acid Hydrochloride CAS 5451-09-2 5-ALA
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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5-Aminolevulinic Acid Hydrochloride: The Complete Guide
5-Aminolevulinic Acid Hydrochloride for Sale
Basic Info of 5-Aminolevulinic Acid Hydrochloride
5-Aminolevulinic Acid Hydrochloride
5-ALA; Aminolevulinic acid hydrochloride; 5-AminoL; 5-Aminolevulinic acid HCl
Pharmaceutical raw materials; Organic raw materials; Flavors and fragrances; Pharmaceutical intermediates
What is 5-Aminolevulinic Acid Hydrochloride?
5-Aminolevulinic acid hydrochloride is a hydrochloride, which is a monohydrochloride of 5-aminolevulinic acid. It is metabolized to protoporphyrin IX, a photoactive compound that builds up in the skin. Utilized in combination with blue light lighting to treat moderate to moderate density actinic keratosis of the face or scalp. It has the function of anti-tumor representative, photosensitizer, skin-related medicine and also prodrug. It includes 5-aminolevulinic acid.
Aminolevulinic acid hydrochloride is a hydrochloride type of aminolevulinic acid (an aminoketone) used for local photosensitive treatment. Aminolevulinic acid (ALA) is a metabolic prodrug that can be exchanged the photosensitizer protoporphyrin IX (PpIX) and also accumulated in cells. Upon exposure to light at appropriate wavelengths (red or blue), PpIX militarizes oxygen to singlet oxygen, a cellular endotoxin that can additionally respond to form superoxide and also hydroxyl radicals. Which brings about cytotoxic results.
A substance produced by succinyl COA and also glycine as intermediates in heme synthesis. It is used as a photochemical treatment for actinic keratosis.
5-Aminolevulinic Acid Hydrochloride Uses
- 5-Aminolevulinic acid hydrochloride is generally used as a substrate for 5-aminolevulinic acid dehydrogenase, biochemical research study.
- 5-Aminolevulinic acid hydrochloride is an all-natural amino acid; made use of as a precursor of tetrapyrrole in the biosynthesis of chlorophyll and heme; antineoplastic medication (photosensitizer).
- 5-Aminolevulinic acid hydrochloride plays a vital duty as a forerunner in the synthesis of tetrapyrrole such as chlorophyll and also heme. It is extensively made use of in photodynamic treatment of conditions, specifically, cervical condyloma acuminatum related to Paget disease as well as human papillomavirus (HPV) infection.
- 5-Aminolevulinic acid (5-ALA) is an intermediate of heme biosynthesis and also can be used in cancer treatment. It is a non protein amino acid.
- 5-ALA has likewise been used in agriculture. It is being studied as an inducer for protoporphyrin IX (PpIX) – reliant fluorescence diagnosis of metastatic lymph nodes.
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Application of 5-Aminolevulinic Acid Hydrochloride
The physiological substance and precursor of heme synthesis, 5-aminolevulinic acid (ALA), is a promising prodrug, which can be used for photodiagnosis and photodynamic therapy of epithelial tumors, especially in urinary and gynecological tissues. The experiment shows that ALA aqueous solution with low pH value may be a dosage form that may be considered for marketing.
Surgical resection is usually the first-line treatment for glioma. However, neurosurgeons face major challenges in achieving maximum resection of high-grade gliomas because these invasive tumors make it difficult to discern tumor margins from the normal brain using traditional white light microscopy alone. In order to help resect these invasive tumors, fluorescence guided surgery is widely popular in intraoperative visualization of malignant glioma, with 5-aminolevulinic acid (5-ALA) in the leading position. 5-ALA was first introduced in an article in neurosurgery and has since become a safe, effective and inexpensive method to visualize and improve the resection of glioma. This undoubtedly led to an improvement in the clinical course of patients, as evidenced by the increase in overall survival and progression free survival of patients with this destructive disease. This literature review aims to discuss major studies and trials demonstrating the clinical utility of 5-ALA and its ability to contribute to complete resection of malignant gliomas.
Clinical Effect of 5-Aminolevulinic Acid Hydrochloride
5-ALA is part of the heme biosynthesis pathway found in all living mammalian cells. As part of this pathway, 5-ALA is metabolized and converted to the fluorescent metabolite protoporphyrin IX (PpIX) through a series of reactions in mitochondria. In physiologically normal cells, PpIX is chelated by iron chelatase to synthesize heme.
Exogenous 5-ALA, as a “prodrug” for oral administration, has shown significant blood-brain barrier (BBB) penetration, especially in areas with high malignant cell density. There are many theories describing the mechanism and cause of 5-ALA and PpIX accumulation in malignant cells. The decreased level of iron chelatase, increased uptake of PpIX by ATP binding cassette B6, increased cell density, increased proliferative activity of malignant tumor cells, increased angiogenesis and increased BBB permeability in malignant tumor areas are all related to the increased fluorescence of glioma In normal cells, PpIX synthesis is regulated by a feedback control system (thus avoiding its accumulation).